ZFIN Lab: Goldman Lab

ZFIN ID: ZDB-LAB-970502-60

Goldman Lab

PI/Director:	Goldman, Dan
Contact Person:	Goldman, Dan
Email:	neuroman@umich.edu
URL:	http://www.mbni.med.umich.edu/mbni/faculty/goldman/goldman.html
Address:	5045 BSRB Molecular and Behavioral Neuroscience Institute University of Michigan 109 Zina Pitcher Place Ann Arbor, MI 48109 USA
Country:	United States
Phone:	(734) 936-3649
Fax:	(734) 936-2690
Line Designation:	mi

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show first 50 of 62 genomic features

STATEMENT OF RESEARCH INTERESTS

Retina and optic nerve regeneration. Muscle activity-dependent gene regulation.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119

Sahu, A., Devi, S., Jui, J., Goldman, D. (2021) Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. Glia. 69(12):2882-2898

Lee, M., Wan, J., Goldman, D. (2020) Tgfb3 collaborates with PP2A and Notch signaling pathways to inhibit retina regeneration. eLIFE. 9:

Krueger, L.D., Thurston, S.E., Kirk, J., Elsaeidi, F., Freeman, Z.T., Goldman, D., Lofgren, J.L., Keller, J.M. (2020) Enrichment Preferences of Singly Housed Zebrafish (Danio rerio). Journal of the American Association for Laboratory Animal Science : JAALAS. 59(2):148-155

Tsuruma, K., Saito, Y., Okuyoshi, H., Yamaguchi, A., Shimazawa, M., Goldman, D., Hara, H. (2018) Granulin 1 Promotes Retinal Regeneration in Zebrafish. Investigative ophthalmology & visual science. 59:6057-6066

Elsaeidi, F., Macpherson, P., Mills, E.A., Jui, J., Flannery, J.G., Goldman, D. (2018) Notch suppression collaborates with Ascl1 and Lin28 to unleash a regenerative response in fish retina, but not in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(9):2246-2261

Wan, J., Goldman, D. (2017) Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Muller Glial Cell Populations that Contribute to Retina Growth and Regeneration. Cell Reports. 19:849-862

Wan, J., Goldman, D. (2016) Retina regeneration in zebrafish. Current opinion in genetics & development. 40:41-47

Powell, C., Cornblath, E., Elsaeidi, F., Wan, J., Goldman, D. (2016) Zebrafish Müller glia-derived progenitors are multipotent, exhibit proliferative biases and regenerate excess neurons. Scientific Reports. 6:24851

Zhang, S., Mu, Z., He, C., Zhou, M., Liu, D., Zhao, X.F., Goldman, D., Xu, H. (2016) Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia-Derived Progenitors During Zebrafish Retinal Regeneration. Investigative ophthalmology & visual science. 57:1991-2000

Powell, C., Cornblath, E., Goldman, D. (2015) Correction: Zinc-binding domain-dependent, deaminase-independent actions of apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 2 (Apobec2), mediate its effect on zebrafish retina regeneration. The Journal of biological chemistry. 290:6007

Skaggs, K., Goldman, D., Parent, J.M. (2014) Excitotoxic brain injury in adult zebrafish stimulates neurogenesis and long-distance neuronal integration. Glia. 62(12):2061-79

Zhao, X.F., Goldman, D. (2014) A New Transgenic Line Reporting pStat3 Signaling in Glia. Zebrafish. 11(6):588-9

Powell, C., Cornblath, E., Goldman, D. (2014) Zinc-binding Domain-dependent, Deaminase-independent Actions of Apolipoprotein B mRNA-editing Enzyme, Catalytic Polypeptide 2 (Apobec2), Mediate Its Effect on Zebrafish Retina Regeneration. The Journal of biological chemistry. 289(42):28924-41

Wan, J., Zhao, X.F., Vojtek, A., Goldman, D. (2014) Retinal Injury, Growth Factors, and Cytokines Converge on β-Catenin and pStat3 Signaling to Stimulate Retina Regeneration. Cell Reports. 9(1):285-97

Zhao, X.F., Wan, J., Powell, C., Ramachandran, R., Myers, M.G., Goldman, D. (2014) Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration. Cell Reports. 9(1):272-84

Goldman, D. (2014) Müller glial cell reprogramming and retina regeneration. Nature reviews. Neuroscience. 15(7):431-42

Goldman, D. (2014) Regeneration, morphogenesis and self-organization. Development (Cambridge, England). 141:2745-9

Elsaeidi, F., Bemben, M.A., Zhao, X.F., and Goldman, D. (2014) Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(7):2632-2644

Powell, C., Grant, A.R., Cornblath, E., and Goldman, D. (2013) Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 110(49):19814-19819

Ramachandran, R., Zhao, X.F., and Goldman, D. (2012) Insm1a-mediated gene repression is essential for the formation and differentiation of Müller glia-derived progenitors in the injured retina. Nature cell biology. 14(10):1013-1023

Wan, J., Ramachandran, R., and Goldman, D. (2012) HB-EGF Is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration. Developmental Cell. 22(2):334-347

Powell, C., Elsaeidi, F., and Goldman, D. (2012) Injury-Dependent Muller Glia and Ganglion Cell Reprogramming during Tissue Regeneration Requires Apobec2a and Apobec2b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(3):1096-1109

Bohnsack, B.L., Kasprick, D.S., Kish, P.E., Goldman, D., and Kahana, A. (2012) A zebrafish model of Axenfeld-Rieger Syndrome reveals that pitx2 regulation by retinoic acid is essential for ocular and craniofacial development. Investigative ophthalmology & visual science. 53(1):7-22

Ramachandran, R., Reifler, A., Wan, J., and Goldman, D. (2012) Application of Cre-loxP Recombination for Lineage Tracing of Adult Zebrafish Retinal Stem Cells. Methods in molecular biology (Clifton, N.J.). 884:129-140

Ramachandran, R., Zhao, X.F., and Goldman, D. (2011) Ascl1a/Dkk/ beta -catenin signaling pathway is necessary and glycogen synthase kinase-3 beta inhibition is sufficient for zebrafish retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 108(38):15858-63

Ghiasvand, N.M., Rudolph, D.D., Mashayekhi, M., Brzezinski, J.A., Goldman, D., and Glaser, T. (2011) Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease. Nature Neuroscience. 14(5):578-586

Ramachandran, R., Fausett, B.V., and Goldman, D. (2010) Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway. Nature cell biology. 12(11):1101-1107

Ramachandran, R., Reifler, A., Parent, J.M., and Goldman, D. (2010) Conditional gene expression and lineage tracing of tuba1a expressing cells during zebrafish development and retina regeneration. The Journal of comparative neurology. 518(20):4196-4212

Veldman, M.B., Bemben, M.A., and Goldman, D. (2010) Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Molecular and cellular neurosciences. 43(4):370-383

Suhr, S.T., Ramachandran, R., Fuller, C.L., Veldman, M.B., Byrd, C.A., and Goldman, D. (2009) Highly-restricted, cell-specific expression of the simian CMV-IE promoter in transgenic zebrafish with age and after heat shock. Gene expression patterns : GEP. 9(1):54-64

Dowling, J.J., Gibbs, E., Russell, M., Goldman, D., Minarcik, J., Golden, J.A., and Feldman, E.L. (2008) Kindlin-2 Is an Essential Component of Intercalated Discs and Is Required for Vertebrate Cardiac Structure and Function. Circulation research. 102(4):423-431

Fausett, B.V., Gumerson, J.D., and Goldman, D. (2008) The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(5):1109-1117

Veldman, M.B., Bemben, M.A., Thompson, R.C., and Goldman, D. (2007) Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Developmental Biology. 312(2):596-612

Buchner, D.A., Su, F., Yamaoka, J.S., Kamei, M., Shavit, J.A., Barthel, L.K., McGee, B., Amigo, J.D., Kim, S., Hanosh, A.W., Jagadeeswaran, P., Goldman, D., Lawson, N.D., Raymond, P.A., Weinstein, B.M., Ginsburg, D., and Lyons, S.E. (2007) pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13996-140001

Catalano, A.E., Raymond, P.A., Goldman, D., and Wei, X. (2007) Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(5):1295-1306

Gulati-Leekha, A., and Goldman, D. (2006) A reporter-assisted mutagenesis screen using α1-tubulin-GFP transgenic zebrafish uncovers missteps during neuronal development and axonogenesis. Developmental Biology. 296(1):29-47

Fausett, B.V., and Goldman, D. (2006) A role for alpha1 tubulin-expressing Muller glia in regeneration of the injured zebrafish retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(23):6303-6313

Sayer, J.A., Otto, E.A., O'toole, J.F., Nurnberg, G., Kennedy, M.A., Becker, C., Hennies, H.C., Helou, J., Attanasio, M., Fausett, B.V., Utsch, B., Khanna, H., Liu, Y., Drummond, I., Kawakami, I., Kusakabe, T., Tsuda, M., Ma, L., Lee, H., Larson, R.G., Allen, S.J., Wilkinson, C.J., Nigg, E.A., Shou, C., Lillo, C., Williams, D.S., Hoppe, B., Kemper, M.J., Neuhaus, T., Parisi, M.A., Glass, I.A., Petry, M., Kispert, A., Gloy, J., Ganner, A., Walz, G., Zhu, X., Goldman, D., Nurnberg, P., Swaroop, A., Leroux, M.R., and Hildebrandt, F. (2006) The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nature Genetics. 38(6):674-681

Tang, H., Veldman, M.B., and Goldman, D. (2006) Characterization of a muscle-specific enhancer in human MuSK promoter reveals the essential role of myogenin in controlling activity-dependent gene regulation. The Journal of biological chemistry. 281(7):3943-3953

Hirata, H., Saint-Amant, L., Waterbury, J., Cui, W., Zhou, W., Li, Q., Goldman, D., Granato, M., and Kuwada, J.Y. (2004) accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1. Development (Cambridge, England). 131(21):5457-5468

Senut, M.C., Gulati-Leekha, A., and Goldman, D. (2004) An element in the alpha1-tubulin promoter is necessary for retinal expression during optic nerve regeneration but not after eye injury in the adult zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(35):7663-7673

Goldman, D., Hankin, M., Li, Z., Dai, X., and Ding, J. (2001) Transgenic zebrafish for studying nervous system development and regeneration. Transgenic Research. 10(1):21-33

Goldman, D. and Ding, J. (2000) Different regulatory elements are necessary for αI tubulin induction during CNS development and regeneration. Neuroreport. 11(17):3859-3863

Petrausch, B., Tabibiazar, R., Roser, T., Jing, Y., Goldman, D., Stürmer, C.A., Irwin, N., and Benowitz, L.I. (2000) A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(21):8031-8041

Hieber, V., Dai, X.H., Foreman, M., and Goldman, D. (1998) Induction of alpha1-tubulin gene expression during development and regeneration of the fish central nervous system. Journal of neurobiology. 37:429-440