Bremer Lab

We use zebrafish to model neuromuscular diseases. Using zebrafish allows us to combine genetic tools (CRISPR/Cas9, transgenesis), modern imaging tools, histological and ultrastructural analysis as well as compound library screens to determine the pathophysiology of neuromuscular diseases like Amyotrophic lateral sclerosis, hereditary peripheral neuropathies and muscle diseases. We focus on determining whether genes that are mutated in neuromuscular diseases control development, maintenance and regeneration of nerves and skeletal muscle. Findings in zebrafish are correlated with clinicopathological observations in affected patients.