ZFIN ID: ZDB-LAB-240108-4
Morsch Lab
PI/Director: Morsch, Marco
Contact Person: Morsch, Marco
Email: marco.morsch@mq.edu.au
URL: https://www.mq.edu.au/research/research-centres-groups-and-facilities/healthy-people/centres/macquarie-university-centre-for-motor-neuron-disease-research/our-people2/morsch-group
Address:
Country: Australia
Phone:
Fax:
Line Designation: mq


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 5 genomic features


STATEMENT OF RESEARCH INTERESTS
1. Understanding the role of abnormal protein aggregates in the pathogenesis of MND

2. Using zebrafish to visualise neuron‐glia interactions underlying MND disease mechanisms

3. Phase separation characteristics of proteins


LAB MEMBERS
Foskett, Kelly Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Shami, G.J., Cheng, D., Morsch, M., Braet, F. (2023) Zebrafish: An emerging and expedient model for liver studies?. Liver international : official journal of the International Association for the Study of the Liver. 43(8):1839-1840
Fu, L., Shi, B., Wen, S., Morsch, M., Wang, G., Zhou, Z., Mi, C., Sadraeian, M., Lin, G., Lu, Y., Jin, D., Chung, R. (2022) Aspect Ratio of PEGylated Upconversion Nanocrystals Affects the Cellular Uptake In Vitro and In Vivo. Acta biomaterialia. 147:403-413
Lau, M., Sealy, B., Combes, V., Morsch, M., Garcia-Bennett, A.E. (2022) Enhanced Antioxidant Effects of the Anti-Inflammatory Compound Probucol When Released from Mesoporous Silica Particles. Pharmaceutics. 14(3):
Cheng, F., De Luca, A., Hogan, A.L., Rayner, S.L., Davidson, J.M., Watchon, M., Stevens, C.H., Muñoz, S.S., Ooi, L., Yerbury, J.J., Don, E.K., Fifita, J.A., Villalva, M.D., Suddull, H., Chapman, T.R., Hedl, T.J., Walker, A.K., Yang, S., Morsch, M., Shi, B., Blair, I.P., Laird, A.S., Chung, R.S., Lee, A. (2021) Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations. Frontiers in molecular neuroscience. 14:627740
Don, E.K., Maschirow, A., Radford, R.A.W., Scherer, N.M., Vidal-Itriago, A., Hogan, A., Maurel, C., Formella, I., Stoddart, J.J., Hall, T.E., Lee, A., Shi, B., Cole, N.J., Laird, A.S., Badrock, A.P., Chung, R.S., Morsch, M. (2021) In vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS). Molecular neurobiology. 58(5):2061-2074
Wang, G., Zhao, X., Wu, H., Lovejoy, D.B., Zheng, M., Lee, A., Fu, L., Miao, K., An, Y., Sayyadi, N., Ding, K., Chung, R.S., Lu, Y., Li, J., Morsch, M., Shi, B. (2020) A Robust Intrinsically Green Fluorescent Poly(Amidoamine) Dendrimer for Imaging and Traceable Central Nervous System Delivery in Zebrafish. Small (Weinheim an der Bergstrasse, Germany). 16(39):e2003654
Cheng, D., Morsch, M., Shami, G.J., Chung, R.S., Braet, F. (2020) Observation and characterisation of macrophages in zebrafish liver. Micron (Oxford, England : 1993). 132:102851
Cheng, D., Morsch, M., Shami, G.J., Chung, R.S., Braet, F. (2018) Albumin uptake and distribution in the zebrafish liver as observed via correlative imaging. Experimental cell research. 374(1):162-171
Hogan, A.L., Don, E.K., Rayner, S.L., Lee, A., Laird, A.S., Watchon, M., Winnick, C., Tarr, I.S., Morsch, M., Fifita, J.A., Gwee, S.S.L., Formella, I., Hortle, E., Yuan, K.C., Molloy, M.P., Williams, K.L., Nicholson, G.A., Chung, R.S., Blair, I.P., Cole, N.J. (2018) Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human molecular genetics. 28(4):698
Formella, I., Svahn, A.J., Radford, R.A.W., Don, E.K., Cole, N.J., Hogan, A., Lee, A., Chung, R.S., Morsch, M. (2018) Real-time visualization of oxidative stress-mediated neurodegeneration of individual spinal motor neurons in vivo. Redox Biology. 19:226-234
Svahn, A.J., Don, E.K., Badrock, A.P., Cole, N.J., Graeber, M.B., Yerbury, J.J., Chung, R., Morsch, M. (2018) Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons. Acta Neuropathologica. 136(3):445-459
Gwee, S.S.L., Radford, R.A.W., Chow, S., Syal, M.D., Morsch, M., Formella, I., Lee, A., Don, E.K., Badrock, A.P., Cole, N.J., West, A.K., Cheung, S.N.S., Chung, R.S. (2018) Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish. Cellular and molecular life sciences : CMLS. 75(23):4269-4285
Fu, L., Morsch, M., Shi, B., Wang, G., Lee, A., Radford, R., Lu, Y., Jin, D., Chung, R. (2017) A versatile upconversion surface evaluation platform for bio-nano surface selection for the nervous system. Nanoscale. 9(36):13683-13692
Chen, L., Watson, C., Morsch, M., Cole, N.J., Chung, R.S., Saunders, D.N., Yerbury, J.J., Vine, K.L. (2017) Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles. Frontiers in neuroscience. 11:476
Lee, A., Rayner, S.L., Gwee, S.S.L., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., Freckleton, S., Shi, B., Walker, A.K., Don, E.K., Cole, N.J., Yang, S., Williams, K.L., Yerbury, J.J., Blair, I.P., Atkin, J.D., Molloy, M.P., Chung, R.S. (2017) Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.. Cellular and molecular life sciences : CMLS. 75(2):335-354
Hogan, A.L., Don, E.K., Rayner, S.L., Lee, A., Laird, A.S., Watchon, M., Winnick, C., Tarr, I.S., Morsch, M., Fifita, J.A., Gwee, S., Formella, I., Hortle, E., Yuan, K., Molloy, M.P., Williams, K.L., Nicholson, G.A., Chung, R.S., Blair, I.P., Cole, N.J. (2017) Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human molecular genetics. 26(14):2616-2626
Morsch, M., Radford, R.A., Don, E.K., Lee, A., Hortle, E., Cole, N.J., Chung, R.S. (2017) Triggering Cell Stress and Death Using Conventional UV Laser Confocal Microscopy. Journal of visualized experiments : JoVE. (120)
Cheng, D., Shami, G., Morsch, M., Huynh, M., Trimby, P., Braet, F. (2017) Relocation is the key to successful correlative fluorescence and scanning electron microscopy. Methods in cell biology. 140:215-244
Morsch, M., Radford, R., Lee, A., Don, E.K., Badrock, A.P., Hall, T.E., Cole, N.J., Chung, R. (2015) In vivo characterization of microglial engulfment of dying neurons in the zebrafish spinal cord. Frontiers in Cellular Neuroscience. 9:321