ZFIN ID: ZDB-LAB-230823-1
Aizawa Lab
PI/Director: Aizawa, Hidenori
Contact Person: Aizawa, Hidenori
Email: haizawa@hiroshima-u.ac.jp
URL: https://neurobio.hiroshima-u.ac.jp/en/
Address: Department of Neurobiology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553 Japan
Country: Japan
Phone: +81-82-257-5115
Line Designation: ha


We use fish and rodents to examine the molecular mechanism underlying psychiatric and neurological disorders. Main projects in the lab are as follows.
1. Roles of the habenula in depression
2. Molecular mechanism underlying spreading depolarization using zebrafish and mice
3. Interaction between cerebral hemispheres


Terai, H., Gwedela, M.N.V., Kawakami, K., Aizawa, H. (2021) Electrophysiological and pharmacological characterization of spreading depolarization in the adult zebrafish tectum. Journal of neurophysiology. 126(6):1934-1942
Victoria Gwedela, M.N., Terai, H., Lampiao, F., Matsunami, K., Aizawa, H. (2021) Anti-seizure effects of medicinal plants in Malawi on pentylenetetrazole-induced seizures in zebrafish larvae. Journal of ethnopharmacology. 284:114763
Amo, R., Fredes, F., Kinoshita, M., Aoki, R., Aizawa, H., Agetsuma, M., Aoki, T., Shiraki, T., Kakinuma, H., Matsuda, M., Yamazaki, M., Takahoko, M., Tsuboi, T., Higashijima, S.I., Miyasaka, N., Koide, T., Yabuki, Y., Yoshihara, Y., Fukai, T., Okamoto, H. (2014) The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger. Neuron. 84:1034-1048
Aoki, T., Kinoshita, M., Aoki, R., Agetsuma, M., Aizawa, H., Yamazaki, M., Takahoko, M., Amo, R., Arata, A., Higashijima, S.I., Tsuboi, T., and Okamoto, H. (2013) Imaging of Neural Ensemble for the Retrieval of a Learned Behavioral Program. Neuron. 78(5):881-894
Aizawa, H. (2013) Habenula and the asymmetric development of the vertebrate brain. Anatomical science international. 88(1):1-9
Okamoto, H., Agetsuma, M., and Aizawa, H. (2012) Genetic dissection of the zebrafish habenula, a possible switching board for selection of behavioral strategy to cope with fear and anxiety. Developmental Neurobiology. 72(3):386-394
Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H. (2010) The habenula is crucial for experience-dependent modification of fear responses in zebrafish. Nature Neuroscience. 13(11):1354-1356
Amo, R., Aizawa, H., Takahoko, M., Kobayashi, M., Takahashi, R., Aoki, T., and Okamoto, H. (2010) Identification of the zebrafish ventral habenula as a homolog of the mammalian lateral habenula. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(4):1566-1574
Okamoto, H., Sato, T., and Aizawa, H. (2008) Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish. Development, growth & differentiation. 50(s1):S167-S175
Sato, T., Hamaoka, T., Aizawa, H., Hosoya, T., and Okamoto, H. (2007) Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(20):5271-5279
Sassa, T., Aizawa, H., and Okamoto, H. (2007) Visualization of two distinct classes of neurons by gad2 and zic1 promoter/enhancer elements in the dorsal hindbrain of developing zebrafish reveals neuronal connectivity related to the auditory and lateral line systems. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(3):706-718
Aizawa, H., Goto, M., Sato, T., and Okamoto, H. (2007) Temporally regulated asymmetric neurogenesis causes left-right difference in the zebrafish habenular structures. Developmental Cell. 12(1):87-98
Aizawa, H., Bianco, I.H., Hamaoka, T., Miyashita, T., Uemura, O., Concha, M.L., Russell, C., Wilson, S.W., and Okamoto, H. (2005) Laterotopic Representation of Left-Right Information onto the Dorso-Ventral Axis of a Zebrafish Midbrain Target Nucleus. Current biology : CB. 15(3):238-243