ZFIN Lab: Ruparelia Lab

ZFIN ID: ZDB-LAB-230509-2

ZFIN ID: ZDB-LAB-230509-2

Ruparelia Lab

PI/Director:	Ruparelia, Avnika
Contact Person:	Ruparelia, Avnika
Email:	avnika.ruparelia@unimelb.edu.au
URL:
Address:	The University of Melbourne Centre for Muscle Research Level 5, Medical Building 181 Corner Royal Parade and Grattan Street Parkville VIC 3010 Australia
Country:	Australia
Phone:	+61 3 8344 8786
Fax:
Line Designation:	uom

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our group is investigating the biology of skeletal muscle ageing, and age-related diseases examining processes such as muscle fiber atrophy and growth, muscle stem cell dynamics, muscle regeneration, and metabolism. We not only utilise the unique advantages of the zebrafish model, but also uses a new experimental system – that of the African killifish, whose extremely short lifespan makes it an attractive model for ageing research.

LAB MEMBERS

Quach, Anna Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Douek, A.M., Klein, E.I., Kaslin, J., Currie, P.D., Ruparelia, A.A. (2021) Cellular and Molecular Characterization of the Effects of the Zebrafish Embryo Genotyper Protocol. Zebrafish. 18(1):92-95

Ruparelia, A.A., McKaige, E.A., Williams, C., Schulze, K.E., Fuchs, M., Oorschot, V., Lacene, E., Meregalli, M., Lee, C., Serrano, R.J., Baxter, E.C., Monro, K., Torrente, Y., Ramm, G., Stojkovic, T., Lavoie, J.N., Bryson-Richardson, R.J. (2020) Metformin rescues muscle function in BAG3 myofibrillar myopathy models. Autophagy. 17(9):2494-2510

de Winter, J.M., Molenaar, J.P., Yuen, M., van der Pijl, R., Shen, S., Conijn, S., van de Locht, M., Willigenburg, M., Bogaards, S.J., van Kleef, E.S., Lassche, S., Persson, M., Rassier, D.E., Sztal, T.E., Ruparelia, A.A., Oorschot, V., Ramm, G., Hall, T.E., Xiong, Z., Johnson, C.N., Li, F., Kiss, B., Lozano-Vidal, N., Boon, R.A., Marabita, M., Nogara, L., Blaauw, B., Rodenburg, R.J., Kϋsters, B., Doorduin, J., Beggs, A.H., Granzier, H., Campbell, K., Ma, W., Irving, T., Malfatti, E., Romero, N.B., Bryson-Richardson, R.J., van Engelen, B.G., Voermans, N.C., Ottenheijm, C.A. (2019) KBTBD13 is an actin-binding protein that modulates muscle kinetics. The Journal of Clinical Investigation. 130(2):754-767

Sztal, T.E., McKaige, E.A., Williams, C., Ruparelia, A.A., Bryson-Richardson, R.J. (2018) Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. PLoS Genetics. 14:e1007212

O'Grady, G.L., Best, H.A., Sztal, T.E., Schartner, V., Sanjuan-Vazquez, M., Donkervoort, S., Abath Neto, O., Sutton, R.B., Ilkovski, B., Romero, N.B., Stojkovic, T., Dastgir, J., Waddell, L.B., Boland, A., Hu, Y., Williams, C., Ruparelia, A.A., Maisonobe, T., Peduto, A.J., Reddel, S.W., Lek, M., Tukiainen, T., Cummings, B.B., Joshi, H., Nectoux, J., Brammah, S., Deleuze, J.F., Ing, V.O., Ramm, G., Ardicli, D., Nowak, K.J., Talim, B., Topaloglu, H., Laing, N.G., North, K.N., MacArthur, D.G., Friant, S., Clarke, N.F., Bryson-Richardson, R.J., Bönnemann, C.G., Laporte, J., Cooper, S.T. (2016) Variants in the Oxidoreductase PYROXD1 Cause Early-Onset Myopathy with Internalized Nuclei and Myofibrillar Disorganization. American journal of human genetics. 99(5):1086-1105

Sztal, T.E., Ruparelia, A.A., Williams, C., Bryson-Richardson, R.J. (2016) Using Touch-evoked Response and Locomotion Assays to Assess Muscle Performance and Function in Zebrafish. Journal of visualized experiments : JoVE. (116)

Leber, Y., Ruparelia, A.A., Kirfel, G., van der Ven, P.F., Hoffmann, B., Merkel, R., Bryson-Richardson, R.J., Fürst, D.O. (2016) Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage. Human molecular genetics. 25(13):2776-2788

Ruparelia, A.A., Oorschot, V., Ramm, G., Bryson-Richardson, R.J. (2016) FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency. Human molecular genetics. 25(11):2131-2142

Ruparelia, A.A., Oorschot, V., Vaz, R., Ramm, G., Bryson-Richardson, R.J. (2014) Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency. Acta Neuropathologica. 128(6):821-33

Ruparelia, A.A., Zhao, M., Currie, P.D., and Bryson-Richardson, R.J. (2012) Characterization and Investigation of zebrafish models of Filamin related myofibrillar myopathy. Human molecular genetics. 21(18):4073-4083