ZFIN ID: ZDB-LAB-190725-1
de Witte Lab
PI/Director: de Witte, Peter
Contact Person: de Witte, Peter
Email: peter.dewitte@kuleuven.be
URL: http://gbiomed.kuleuven.be/english/research/50000715/52455311/
Address: Laboratory for Molecular Biodiscovery KU Leuven, Gasthuisberg O&N 2 Herestraat 49, box 824 3000 Leuven
Country: Belgium
Phone: +32 16 32 34 32
Fax:
Line Designation: lv


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 5 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS
Janssens, Sophie Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Kokkini, M., Oves-Costales, D., Sánchez, P., Melguizo, Á., Mackenzie, T.A., Pérez-Bonilla, M., Martín, J., Giusti, A., de Witte, P., Vicente, F., Genilloud, O., Reyes, F. (2023) New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains. Marine drugs. 21(8):
Cuvry, A., Gozalbo-Rovira, R., Strubbe, D., Neyts, J., de Witte, P., Rodríguez-Díaz, J., Rocha-Pereira, J. (2022) The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae. Microbiology spectrum. 10(6):e0315722
Pardon, M., Claes, P., Druwé, S., Martini, M., Siekierska, A., Menet, C., de Witte, P.A.M., Copmans, D. (2022) Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor. Frontiers in pharmacology. 13:1012622
De Meulemeester, A.S., Heylen, L., Siekierska, A., Mills, J.D., Romagnolo, A., Van Der Wel, N.N., Aronica, E., de Witte, P.A.M. (2022) Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities. Frontiers in cell and developmental biology. 10:952832
Adant, I., Bird, M., Decru, B., Windmolders, P., Wallays, M., de Witte, P., Rymen, D., Witters, P., Vermeersch, P., Cassiman, D., Ghesquière, B. (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. Molecular metabolism. 63:101537
Zhang, Y., Heylen, L., Partoens, M., Mills, J.D., Kaminski, R.M., Godard, P., Gillard, M., de Witte, P.A.M., Siekierska, A. (2022) Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery. Frontiers in molecular neuroscience. 15:881933
Copmans, D., Kildgaard, S., Roux, E., Partoens, M., Steurs, G., Wang, X., De Borggraeve, W.M., Esguerra, C.V., Crawford, A.D., Larsen, T.O., de Witte, P.A.M. (2022) From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin. Pharmaceuticals (Basel, Switzerland). 15(2):
Kozioł, E., Jóźwiak, K., Budzyńska, B., de Witte, P.A.M., Copmans, D., Skalicka-Woźniak, K. (2021) Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish. International Journal of Molecular Sciences. 22(21):
Heylen, L., Pham, D.H., De Meulemeester, A.S., Samarut, É., Skiba, A., Copmans, D., Kazwiny, Y., Vanden Berghe, P., de Witte, P.A.M., Siekierska, A. (2021) Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish. Frontiers in molecular neuroscience. 14:753936
Mamot, A., Sikorski, P.J., Siekierska, A., de Witte, P., Kowalska, J., Jemielity, J. (2021) Ethylenediamine derivatives efficiently react with oxidized RNA 3' ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation. Nucleic acids research. 50(1):e3
Van Dycke, J., Dai, W., Stylianidou, Z., Li, J., Cuvry, A., Roux, E., Li, B., Rymenants, J., Bervoets, L., de Witte, P., Liu, H., Neyts, J., Rocha-Pereira, J. (2021) A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo. Viruses. 13(9):
Berlingerio, S.P., He, J., De Groef, L., Taeter, H., Norton, T., Baatsen, P., Cairoli, S., Goffredo, B., de Witte, P., van den Heuvel, L., Baelde, H.J., Levtchenko, E. (2021) Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis. International Journal of Molecular Sciences. 22(17):
Partoens, M., De Meulemeester, A.S., Giong, H.K., Pham, D.H., Lee, J.S., de Witte, P.A., Siekierska, A. (2021) Modelling neurodevelopmental disorders and epilepsy caused by loss of function of kif2a in zebrafish. eNeuro. 8(5):
Guarin, M., Faelens, R., Giusti, A., De Croze, N., Léonard, M., Cabooter, D., Annaert, P., de Witte, P., Ny, A. (2021) Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration. Scientific Reports. 11:12229
Li, J., Nelis, M., Sourbron, J., Copmans, D., Lagae, L., Cabooter, D., de Witte, P.A.M. (2021) Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome. Neurochemical research. 46(9):2249-2261
Van Dycke, J., Cuvry, A., Knickmann, J., Ny, A., Rakers, S., Taube, S., de Witte, P., Neyts, J., Rocha-Pereira, J. (2021) Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors. Nature Protocols. 16(4):1830-1849
Wang, X., Giusti, A., Ny, A., de Witte, P.A. (2020) Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid. toxins. 12(4):
Li, J., Copmans, D., Partoens, M., Hunyadi, B., Luyten, W., de Witte, P. (2020) Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model. ACS Chemical Neuroscience. 11(5):730-742
Hotterbeekx, A., Raimon, S., Abd-Elfarag, G., Y Carter, J., Sebit, W., Suliman, A., Nelson Siewe Fodjo, J., De Witte, P., Yibi Logora, M., Colebunders, R., Kumar-Singh, S. (2019) Onchocerca volvulus is not detected in the cerebrospinal fluid of persons with onchocerciasis-associated epilepsy. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 91:119-123
Copmans, D., Kildgaard, S., Rasmussen, S.A., Ślęzak, M., Dirkx, N., Partoens, M., Esguerra, C.V., Crawford, A.D., Larsen, T.O., de Witte, P.A.M. (2019) Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B. Marine drugs. 17(11):
Van Dycke, J., Ny, A., Conceição-Neto, N., Maes, J., Hosmillo, M., Cuvry, A., Goodfellow, I., Nogueira, T.C., Verbeken, E., Matthijnssens, J., de Witte, P., Neyts, J., Rocha-Pereira, J. (2019) A robust human norovirus replication model in zebrafish larvae. PLoS pathogens. 15:e1008009
Giusti, A., Nguyen, X.B., Kislyuk, S., Mignot, M., Ranieri, C., Nicolaï, J., Oorts, M., Wu, X., Annaert, P., De Croze, N., Léonard, M., Ny, A., Cabooter, D., de Witte, P. (2019) Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos. International Journal of Molecular Sciences. 20(7):
Siekierska, A., Stamberger, H., Deconinck, T., Oprescu, S.N., Partoens, M., Zhang, Y., Sourbron, J., Adriaenssens, E., Mullen, P., Wiencek, P., Hardies, K., Lee, J.S., Giong, H.K., Distelmaier, F., Elpeleg, O., Helbig, K.L., Hersh, J., Isikay, S., Jordan, E., Karaca, E., Kecskes, A., Lupski, J.R., Kovacs-Nagy, R., May, P., Narayanan, V., Pendziwiat, M., Ramsey, K., Rangasamy, S., Shinde, D.N., Spiegel, R., Timmerman, V., von Spiczak, S., Helbig, I., C4RCD Research Group, AR working group of the EuroEPINOMICS RES Consortium, Weckhuysen, S., Francklyn, C., Antonellis, A., de Witte, P., De Jonghe, P. (2019) Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish. Nature communications. 10:708
Swaminathan, A., Hassan-Abdi, R., Renault, S., Siekierska, A., Riché, R., Liao, M., de Witte, P.A.M., Yanicostas, C., Soussi-Yanicostas, N., Drapeau, P., Samarut, É. (2018) Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development. Current biology : CB. 28(12):1924-1937.e5
Leclercq, K., Afrikanova, T., Langlois, M., De Prins, A., Buenafe, O.E., Rospo, C.C., Van Eeckhaut, A., de Witte, P.A., Crawford, A.D., Smolders, I., Esguerra, C.V., Kaminski, R.M. (2015) Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. Epilepsy & behavior : E&B. 45:53-63
Challal, S., Buenafe, O.E., Queiroz, E.F., Maljevic, S., Marcourt, L., Bock, M., Kloeti, W., Dayrit, F.M., Harvey, A.L., Lerche, H., Esguerra, C.V., de Witte, P.A., Wolfender, J.L., Crawford, A.D. (2014) Zebrafish-bioassay guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum. ACS Chemical Neuroscience. 5(10):993-1004
Buenafe, O.E., Orellana Paucar, A.M., Maes, J., Huang, H., De Borggraeve, W.M., Crawford, A.D., Luyten, W., Esguerra, C.V., and de Witte, P. (2013) Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ACS Chemical Neuroscience. 4(11):1479-87
Afrikanova, T., Serruys, A.S., Buenafe, O.E., Clinckers, R., Smolders, I., de Witte, P.A., Crawford, A.D., and Esguerra, C.V. (2013) Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs. PLoS One. 8(1):e54166
Challal, S., Bohni, N., Buenafe, O.E., Esguerra, C.V., de Witte, P.A., Wolfender, J.L., and Crawford, A.D. (2012) Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products. Chimia. 66(4):229-232
Maes, J., Verlooy, L., Buenafe, O.E., de Witte, P.A., Esguerra, C.V., and Crawford, A.D. (2012) Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae. PLoS One. 7(10):e43850