ZFIN ID: ZDB-LAB-180907-1
Aaron Goldman Lab
PI/Director: Goldman, Joseph
Contact Person: Goldman, Joseph
Email: goldman.214@osu.edu
URL:
Address: 105 Rightmire Hall, 1060 Carmack Rd., Columbus, OH 43210
Country: United States
Phone: 614-293-3366
Fax:
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Heart disease is the leading cause of death in the world today. A central feature of heart disease is the permanent loss of heart muscle, which regenerates very poorly in humans. Unlike humans, zebrafish can replenish up to 60% of lost heart muscle or cardiomyocytes (CM) without adverse effects or scarring. Only some of the factors involved in this regeneration have been identified; others remain to be discovered. One major challenge has been to reveal master regulators that define regenerative capacity.

The long-term goal of my laboratory is to identify the gene regulatory network that governs regeneration. Transcriptional control is likely a key feature of regeneration competency as thousands of genes change in expression. As primary determinants of gene regulation, transcription factors not normally active in uninjured CMs are likely required for triggering regeneration. Yet, the identity of these factors remains elusive. Similarly, changes in chromatin packaging integral during development may likewise underpin competency for regeneration. Nucleosome reorganization may be a critical feature of normally dormant cis-regulatory elements and promoters. My research program aims to identify novel transcription factors and chromatin regulation governing zebrafish heart regeneration.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Pronobis, M.I., Zheng, S., Singh, S.P., Goldman, J.A., Poss, K.D. (2021) In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration. eLIFE. 10:
Goldman, J.A., Kuzu, G., Lee, N., Karasik, J., Gemberling, M., Foglia, M.J., Karra, R., Dickson, A.L., Sun, F., Tolstorukov, M.Y., Poss, K.D. (2017) Resolving Heart Regeneration by Replacement Histone Profiling. Developmental Cell. 40:392-404.e5
Kang, J., Hu, J., Karra, R., Dickson, A.L., Tornini, V.A., Nachtrab, G., Gemberling, M., Goldman, J.A., Black, B.L., Poss, K.D. (2016) Modulation of tissue repair by regeneration enhancer elements. Nature. 532(7598):201-6