ZFIN ID: ZDB-LAB-180116-1
Shulan Yang Lab
PI/Director: Yang, Shulan
Contact Person: Yang, Shulan
Email: yangshl3@mail.sysu.edu.cn
Address: Center for Translational Medicine, The first Affiliated Hospital, Sun Yat-sen University; Zebrafish Core Facility, Institute of Clinical and Translational Research, Sun Yat-Sen University; No. 58, Zhongshan Road 2nd, Guangzhou 510080
Country: China
Phone: 86-20-87755766-8459
Line Designation: syu


We focus on several novel genes which involve in metastasis-promoting or tumorigenesis, and try to manifest their physiological roles in organogenesis and the carcinogenesis by their expression alteration using Zebrafish as model. So far, the lines with small deletion or transgenic insertion of these genes were setting up using CRISPR/Cas9 or Tol2 transgenic system.


Yang, S., Emelyanov, A., You, M.S., Sin, M., Korzh, V. (2020) Camel regulates development of the brain ventricular system. Cell and tissue research. 383(2):835-852
Lin, J., Liang, J., Wen, J., Luo, M., Li, J., Sun, X., Xu, X., Li, J., Wang, D., Wang, J., Chen, H., Lai, R., Liang, F., Li, C., Ye, F., Zhang, J., Zeng, J., Yang, S., Sheng, W. (2020) Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 41(6):1251-1263
Wang, J., Guo, X., Wang, D., Yang, S. (2020) Expression patterns of pcbp gene family members during zebrafish embryogenesis. Gene expression patterns : GEP. 35:119097
Zhou, T., Chen, C., Xu, C., Zhou, H., Gao, B., Su, D., Liao, Z., Li, Y., Yang, S., Su, P. (2018) Mutant MAPK7-Induced Idiopathic Scoliosis is Linked to Impaired Osteogenesis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 48:880-890
Gao, W., Chen, C., Zhou, T., Yang, S., Gao, B., Zhou, H., Lian, C., Wu, Z., Qiu, X., Yang, X., Alattar, E., Liu, W., Su, D., Sun, S., Chen, Y., Cheung, K.M.C., Song, Y., Luk, K.K.D., Chan, D., Sham, P.C., Xing, C., Khor, C.C., Liu, G., Yang, J., Deng, Y., Hao, D., Huang, D., Li, Q.Z., Xu, C., Su, P. (2017) Rare coding variants in MAPK7 predispose to adolescent idiopathic scoliosis. Human Mutation. 38(11):1500-1510
Tong, F., Zhang, M., Guo, X., Shi, H., Li, L., Guan, W., Wang, H., Yang, S. (2016) Expression patterns of SH3BGR family members in zebrafish development. Development genes and evolution. 226(4):287-95
Li, L., Shi, H., Zhang, M., Guo, X., Tong, F., Zhang, W., Zhou, J., Wang, H., Yang, S. (2016) Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology. 48(4):1541-52
Yang, S.L., Aw, S.S., Chang, C., Korzh, S., Korzh, V., and Peng, J. (2011) Depletion of Bhmt Elevates sonic hedgehog Transcript Level and Increases β-Cell Number in Zebrafish. Endocrinology. 152(12):4706-17
Korzh, S., Winata, C.L., Zheng, W., Yang, S., Yin, A., Ingham, P., Korzh, V., and Gong, Z. (2011) The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Developmental Biology. 359(2):262-76