ZFIN ID: ZDB-LAB-170216-10
Zhong Tao P. Lab
PI/Director: Zhong, Tao P.
Co-PI / Senior
Jin, Daqing
Contact Person:
Email: taozhong@fudan.edu.cn
Address: E201 Biological Science Building, 2005 Songhu Road, Shanghai200438, China
Country: China
Phone: 86-21-51630547
Fax: 86-21-51630547
Line Designation: None assigned


Our research interests is to understand the cellular and molecular mechanisms of cardiovascular development, heart regeneration, ciliogenesis and organ formation.


Cai, Y., Wang, J., Jin, D., Liu, Q., Xianglei, C., Lili, P., Yang, L., Wang, X., Qian, F., Wang, J., Zhong, T.P., Wang, S. (2021) Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway. Cancer science. 112(9):3884-3894
Sun, J., She, P., Liu, X., Gao, B., Jin, D., Zhong, T.P. (2020) Disruption of Abcc6 Transporter in Zebrafish Causes Ocular Calcification and Cardiac Fibrosis. International Journal of Molecular Sciences. 22(1):
She, P., Zhang, H., Peng, X., Sun, J., Gao, B., Zhou, Y., Zhu, X., Hu, X., Lai, K.S., Wong, J., Zhou, B., Wang, L., Zhong, T.P. (2020) The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. Development (Cambridge, England). 147(18):
Peng, X., Lai, K.S., She, P., Kang, J., Wang, T., Li, G., Zhou, Y., Sun, J., Jin, D., Xu, X., Liao, L., Liu, J., Lee, E., Poss, K.D., Zhong, T.P. (2020) Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of molecular cell biology. 13(1):41-58
Fang, Y., Lai, K.S., She, P., Sun, J., Tao, W., Zhong, T.P. (2020) Tbx20 Induction Promotes Zebrafish Heart Regeneration by Inducing Cardiomyocyte Dedifferentiation and Endocardial Expansion. Frontiers in cell and developmental biology. 8:738
Zhao, W., Cao, L., Ying, H., Zhang, W., Li, D., Zhu, X., Xue, W., Wu, S., Cao, M., Fu, C., Qi, H., Hao, Y., Tang, Y.C., Qin, J., Zhong, T.P., Lin, X., Yu, L., Li, X., Li, L., Wu, D., Pan, W. (2019) Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Research. 29(11):895-910
Li, G., Jin, D., Zhong, T.P. (2019) Tubgcp3 Is Required for Retinal Progenitor Cell Proliferation During Zebrafish Development. Frontiers in molecular neuroscience. 12:126
Xie, S., Fu, W., Yu, G., Hu, X., Lai, K.S., Peng, X., Zhou, Y., Zhu, X., Christov, P., Sawyer, L., Ni, T.T., Sulikowski, G.A., Yang, Z., Lee, E., Zeng, C., Wang, W.E., Zhong, T.P. (2019) Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair. Journal of molecular cell biology. 12(1):42-54
Li, W., Jin, D., Zhong, T.P. (2019) Photoreceptor cell development requires prostaglandin signaling in the zebrafish retina. Biochemical and Biophysical Research Communications. 510(2):230-235
Zhang, R., He, J., Wang, X., Pan, W., Cao, Y., Zu, Y., Jiang, Q., Du, J., Zhong, T.P. (2018) Report of the Fifth Zebrafish Research Conference of China. Zebrafish. 16(1):128-134
Yang, X., Li, J., Fang, Y., Zhang, Z., Jin, D., Chen, X., Zhao, Y., Li, M., Huan, L., Kent, T.A., Dong, J.F., Jiang, R., Yang, S., Jin, L., Zhang, J., Zhong, T.P., Yu, F. (2018) Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms.. Circulation. Genomic and precision medicine. 11:e002099
Jin, D., Zhu, D., Fang, Y., Chen, Y., Yu, G., Pan, W., Liu, D., Li, F., Zhong, T.P. (2017) Vegfa signaling regulates diverse artery/vein formation in vertebrate vasculatures. Journal of genetics and genomics = Yi chuan xue bao. 44(10):483-492
Liu, P., Zhong, T.P. (2017) MAPK/ERK signalling is required for zebrafish cardiac regeneration. Biotechnology Letters. 39(7):1069-1077
Zhu, D., Fang, Y., Gao, K., Shen, J., Zhong, T.P., Li, F. (2017) Vegfa Impacts Early Myocardium Development in Zebrafish. International Journal of Molecular Sciences. 18(2)
Peng, X., He, Q., Li, G., Ma, J., Zhong, T.P. (2016) Rac1-PAK2 pathway is essential for zebrafish heart regeneration. Biochemical and Biophysical Research Communications. 472(4):637-42
Jin, D., Liu, P., Zhong, T.P. (2015) Prostaglandin signaling in ciliogenesis during development. Cell cycle (Georgetown, Tex.). 14:1-2
Jin, D., Ni, T.T., Sun, J., Wan, H., Amack, J.D., Yu, G., Fleming, J., Chiang, C., Li, W., Papierniak, A., Cheepala, S., Conseil, G., Cole, S.P., Zhou, B., Drummond, I.A., Schuetz, J.D., Malicki, J., Zhong, T.P. (2014) Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nature cell biology. 16(9):841-51
Dai, X., She, P., Chi, F., Feng, Y., Liu, H., Jin, D., Zhao, Y., Guo, X., Jiang, D., Guan, K.L., Zhong, T.P., and Zhao, B. (2013) Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration and angiogenesis. The Journal of biological chemistry. 288(47):34041-51
Sun, Y., Dong, Z., Jin, T., Ang, K.H., Huang, M., Haston, K.M., Peng, J., Zhong, T.P., Finkbeiner, S., Weiss, W.A., Arkin, M.R., Jan, L.Y., and Guo, S. (2013) Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. eLIFE. 2:e00508
Cheepala, S.B., Bao, J., Nachagari, D., Sun, D., Wang, Y., Zhong, T., Naren, A.P., Zheng, J., and Schuetz, J.D. (2013) Crucial Role for Phylogenetically Conserved Cytoplasmic Loop 3 in ABCC4 Expression. The Journal of biological chemistry. 288(31):22207-18
Ding, Y., Liu, W., Deng, Y., Jomok, B., Yang, J., Huang, W., Clark, K.J., Zhong, T., Lin, X., Ekker, S.C., and Xu, X. (2013) Trapping Cardiac Recessive Mutants via Expression-based Insertional Mutagenesis Screening. Circulation research. 112(4):606-617
Ni, T.T., Lu, J., Zhu, M., Maddison, L.A., Boyd, K.L., Huskey, L., Ju, B., Hesselson, D., Zhong, T.P., Page-McCaw, P.S., Stainier, D.Y., and Chen, W. (2012) Conditional control of gene function by an invertible gene trap in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(38):15389-15394
Ni, T.T., Rellinger, E.J., Mukherjee, A., Xie, S., Stephens, L., Thorne, C.A., Kim, K., Hu, J., Lee, E., Marnett, L., Hatzopoulos, A.K., and Zhong, T.P. (2011) Discovering Small Molecules that Promote Cardiomyocyte Generation by Modulating Wnt Signaling. Chemistry & Biology. 18(12):1658-1668
Williams, C., Kim, S.H., Ni, T.T., Mitchell, L., Ro, H., Penn, J.S., Baldwin, S.H., Solnica-Krezel, L., and Zhong, T.P. (2010) Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Developmental Biology. 341(1):196-204
Chopra, S.S., Stroud, D.M., Watanabe, H., Bennett, J.S., Burns, C.G., Wells, K.S., Yang, T., Zhong, T.P., and Roden, D.M. (2010) Voltage-Gated Sodium Channels Are Required for Heart Development in Zebrafish. Circulation research. 106(8):1342-1350
Jin, D., Ni, T.T., Hou, J., Rellinger, E., and Zhong, T.P. (2009) Promoter analysis of ventricular myosin heavy chain (vmhc) in zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 238(7):1760-1767
Zeng, X.X., Zheng, X., Xiang, Y., Cho, H.P., Jessen, J.R., Zhong, T.P., Solnica-Krezel, L., and Brown, H.A. (2009) Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish. Developmental Biology. 328(2):363-376
Qu, X., Jia, H., Garrity, D.M., Tompkins, K., Batts, L., Appel, B., Zhong, T.P., and Baldwin, H.S. (2008) ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Developmental Biology. 317(2):486-496
Jia, H., King, I.N., Chopra, S.S., Wan, H., Ni, T.T., Jiang, C., Guan, X., Wells, S., Srivastava, D., and Zhong, T.P. (2007) Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proceedings of the National Academy of Sciences of the United States of America. 104(35):14008-14013
Chopra, S.S., Watanabe, H., Zhong, T.P., and Roden, D.M. (2007) Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: Implications for the evolution of electrical signaling in vertebrates. BMC Evolutionary Biology. 7(1):113
Wang, Y.X., Qian, L.X., Liu, D., Yao, L.L., Jiang, Q., Yu, Z., Gui, Y.H., Zhong, T.P., and Song, H.Y. (2007) Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility. Cardiovascular research. 74(2):290-303
Rutenberg, J.B., Fischer, A., Jia, H., Gessler, M., Zhong, T.P., and Mercola, M. (2006) Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (Cambridge, England). 133(21):4381-4390
Wang, Y., Qian, L., Dong, Y., Jiang, Q., Gui, Y., Zhong, T.P., and Song, H. (2006) Myocyte-specific enhancer factor 2A is essential for zebrafish posterior somite development. Mechanisms of Development. 123(10):783-791
Campbell, W.A., Yang, H., Zetterberg, H., Baulac, S., Sears, J.A., Liu, T., Wong, S.T., Zhong, T.P., and Xia, W. (2006) Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. Journal of neurochemistry. 96(5):1423-1440
Zhang, L., Zhong, T., Wang, Y., Jiang, Q., Song, H., and Gui, Y. (2006) TBX1, a DiGeorge syndrome candidate gene, is inhibited by retinoic acid. The International journal of developmental biology. 50(1):55-61
Wang, Y., Zhong, T., Qian, L., Dong, Y., Jiang, Q., Tan, L., and Song, H. (2005) Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase. Biochemical and Biophysical Research Communications. 331(1):303-308
Xu, X., Meiler, S.E., Zhong, T.P., Mohideen, M., Crossley, D.A., Burggren, W.W., and Fishman, M.C. (2002) Cardiomyopathy in zebrafish due to mutation in an alternatively spliced exon of titin. Nature Genetics. 30(2):205-209
Zhong, T.P., Childs, S., Leu, J.P., and Fishman, M.C. (2001) Gridlock signalling pathway fashions the first embryonic artery. Nature. 414(6860):216-220
Zhong, T.P., Rosenberg, M., Mohideen, M.A.P.K., Weinstein, B., and Fishman, M.C. (2000) gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science (New York, N.Y.). 287(5459):1820-1824
Amemiya, C.T., Zhong, T.P., Silverman, G.A., Fishman, M.C., and Zon, L.I. (1999) Zebrafish YAC, BAC, and PAC genomic libraries. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:235-258
Zhong, T.P., Kaphingst, K., Akella, U., Haldi, M., Lander, E.S., and Fishman, M.C. (1998) Zebrafish genomic library in yeast artificial chromosomes. Genomics. 48:136-138