ZFIN Lab: Zhihong Lab

ZFIN ID: ZDB-LAB-170209-13

Zhihong Lab

PI/Director:	Liu, Zhihong
Contact Person:	Chen, Zhaohong
Email:	czh4@sina.com
URL:
Address:	National Clinical Research Center of Kidney Diseases Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Country:	China
Phone:	86-25-84801992
Fax:	86-25-84801992
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

We are interested in using zebrafish as model organism for identify and study glomerular disease-associated molecules and related pathogenic mechanisms.

LAB MEMBERS

Wang, Ling MD/Veterinarian	Chen, Zhaohong Post-Doc	Li, Zhi Post-Doc
Zhang, Liwen Post-Doc	Hou, Qing Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Cai, X., Wang, R., Zhu, J., Li, X., Liu, X., Ouyang, G., Wang, J., Li, Z., Zhu, C., Deng, H., Xiao, W. (2023) Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ. Cell Reports. 43:113606113606

Peng, F., Zhou, L., Lu, W., Gan, R., Lu, M., Li, Z., Zhang, X., Wang, Y., Gui, J. (2023) Genomic and Transcriptional Profiles of Kelch-like (klhl) Gene Family in Polyploid Carassius Complex. International Journal of Molecular Sciences. 24(9):

Liwen, Z., Song, J., Shi, J., Xu, X., Wang, L., Xiuwen, Z., Hou, Q., Weisong, Q., Chen, Z. (2023) TYRO3 protects podocyte via JNK/c-jun-P53 pathway. Archives of biochemistry and biophysics. 739:109578

Song, Y., Fan, S., Zhang, D., Li, J., Li, Z., Li, Z., Xiao, W., Wang, J. (2023) Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein. Journal of virology. 97(2):e0133822

Zhou, J., Yang, Y.J., Gan, R.H., Wang, Y., Li, Z., Zhang, X.J., Gui, J.F., Zhou, L. (2022) Foxl2a and Foxl2b are involved in midbrain-hindbrain boundary development in zebrafish. Gene expression patterns : GEP. 46:119286

Xiao, J., Meng, X., Chen, K., Wang, J., Wu, L., Chen, Y., Yu, X., Feng, J., Li, Z. (2022) Down-Regulation of Double C2 Domain Alpha Promotes the Formation of Hyperplastic Nerve Fibers in Aganglionic Segments of Hirschsprung's Disease. International Journal of Molecular Sciences. 23(18)

Gong, X.Y., Zhang, Q.M., Zhao, X., Li, Y.L., Qu, Z.L., Li, Z., Dan, C., Gui, J.F., Zhang, Y.B. (2022) LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response. iScience. 25:104821

Lu, L.F., Jiang, J.Y., Du, W.X., Wang, X.L., Li, Z.C., Zhou, X.Y., Zhang, C., Mou, C.Y., Chen, D.D., Li, Z., Zhou, L., Gui, J.F., Li, X.Y., Li, S. (2022) Fish female-biased gene cyp19a1a leads to female antiviral response attenuation between sexes by autophagic degradation of MITA. PLoS pathogens. 18:e1010626

Cai, X., Zhou, Z., Zhu, J., Liu, X., Ouyang, G., Wang, J., Li, Z., Li, X., Zha, H., Zhu, C., Rong, F., Tang, J., Liao, Q., Chen, X., Xiao, W. (2022) Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses. Cell Reports. 39:110920

Zhou, Z., Cai, X., Zhu, J., Li, Z., Yu, G., Liu, X., Ouyang, G., Xiao, W. (2021) Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 207(1):244-256

Duan, A., Wang, H., Zhu, Y., Wang, Q., Zhang, J., Hou, Q., Xing, Y., Shi, J., Hou, J., Qin, Z., Chen, Z., Liu, Z., Yang, J. (2021) Chromatin architecture reveals cell type-specific target genes for kidney disease risk variants. BMC Biology. 19:38

Li, Z., Fan, S., Wang, J., Chen, X., Liao, Q., Liu, X., Ouyang, G., Cao, H., Xiao, W. (2020) Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 205(7):1897-1908

Wang, Z., Gu, Z., Hou, Q., Chen, W., Mu, D., Zhang, Y., Liu, Q., Liu, Z., Yang, D. (2020) Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic-Acute Kidney Injury In Vivo. Journal of immunology (Baltimore, Md. : 1950). 204(7):1929-1942

Li, S., Song, D., Huang, W., Li, Z., Liu, Z. (2020) In-situ Imaging of Cysteine in the Brains of Mice with Epilepsy by a Near-infrared Emissive Fluorescent Probe. Analytical chemistry. 92(3):2802-2808

Zhai, X., Wang, L., Xu, C., Hou, Q., Zhang, L., Li, Z., Qin, W., Liu, Z., Chen, Z. (2019) Triptolide preserves glomerular barrier function via the inhibition of p53-mediated increase of GADD45B. Archives of biochemistry and biophysics. 671:210-217

Zhang, Y., Li, Z., Hu, W., Liu, Z. (2019) A Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Visualizing and Monitoring Viscosity in Live Cells and Tissues. Analytical chemistry. 91(15):10302-10309

Zhong, F., Chen, Z., Zhang, L., Xie, Y., Nair, V., Ju, W., Kretzler, M., Nelson, R.G., Li, Z., Chen, H., Wang, Y., Zhang, A., Lee, K., Liu, Z., He, J.C. (2018) Tyro3 is a podocyte protective factor in glomerular disease. JCI insight. 3(22):

He, W.X., Wu, M., Liu, Z., Li, Z., Wang, Y., Zhou, J., Yu, P., Zhang, X.J., Zhou, L., Gui, J.F. (2018) Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis. RNA (New York, N.Y.). 24(12):1738-1748

Wang, L., Zhang, L., Hou, Q., Zhu, X., Chen, Z., Liu, Z. (2018) Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B. Scientific Reports. 8:10843

Pan, Y., Jiang, S., Hou, Q., Qiu, D., Shi, J., Wang, L., Chen, Z., Zhang, M., Duan, A., Qin, W., Zen, K., Liu, Z. (2017) Dissection of Glomerular Transcriptional Profile in Patients with Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function. Diabetes. 67(4):717-730

Zhang, Q.M., Zhao, X., Li, Z., Wu, M., Gui, J.F., Zhang, Y.B. (2017) Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response. Journal of immunology (Baltimore, Md. : 1950). 200(2):688-703

Xiong, S., Mei, J., Huang, P., Jing, J., Li, Z., Kang, J., Gui, J.F. (2017) Essential roles of stat5.1/stat5b in controlling fish somatic growth. Journal of genetics and genomics = Yi chuan xue bao. 44(12):577-585

Lin, Q., Mei, J., Li, Z., Zhang, X., Zhou, L., Gui, J.F. (2017) Distinct and Cooperative Roles of amh and dmrt1 in Self-Renewal and Differentiation of Male Germ Cells in Zebrafish.. Genetics. 207(3):1007-1022

Li, S.Z., Liu, W., Li, Z., Li, W.H., Wang, Y., Zhou, L., Gui, J.F. (2017) greb1 regulates convergent extension movement and pituitary development in zebrafish. Gene. 627:176-187

Sun, Z.H., Zhou, L., Li, Z., Liu, X.C., Li, S.S., Wang, Y., Gui, J.F. (2017) Sexual dimorphic expression of dnd in germ cells during sex reversal and its requirement for primordial germ cell survival in protogynous hermaphroditic grouper. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 208-209:47-57

Zhang, K.C., Cao, Y.D., Yao, F., Zhang, L., Ding, A.W. (2017) [Acute toxicity of Euphorbiae Pekinensis Radix and vinegar-processing Euphorbiae Pekinensis Radix on zebrafish embryo]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 42:2291-2297

Yang, Y.J., Wang, Y., Li, Z., Zhou, L., Gui, J.F. (2017) Sequential, Divergent, and Cooperative Requirements of Foxl2a and Foxl2b in Ovary Development and Maintenance of Zebrafish.. Genetics. 205(4):1551-1572

Xiong, S., Wu, J, Jing, J., Huang, P., Li, Z., Mei, J., Gui, J.F, (2017) Loss of stat3 function leads to spine malformation and immune disorder in zebrafish. Science Bulletin. 62:Pages 185-196

Dong, X., Li, Z., Wang, X., Zhou, M., Lin, L., Zhou, Y., Li, J. (2016) Characteristics of Vibrio parahaemolyticus isolates obtained from crayfish (Procambarus clarkii) in freshwater. International journal of food microbiology. 238:132-138

Zhu, X., Chen, Z., Zeng, C., Wang, L., Xu, F., Hou, Q., Liu, Z. (2016) Ultrastructural characterization of the pronephric glomerulus development in zebrafish. Journal of morphology. 277(8):1104-12

Wan, X., Chen, Z., Choi, W.I., Gee, H.Y., Hildebrandt, F., Zhou, W. (2016) Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1. Journal of the American Society of Nephrology : JASN. 27(4):1066-75

Chen, Z., Wan, X., Hou, Q., Shi, S., Wang, L., Chen, P., Zhu, X., Zeng, C., Qin, W., Zhou, W., Liu, Z. (2016) GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway. Cell Death & Disease. 7:e2068

Jing, J., Xiong, S., Li, Z., Wu, J., Zhou, L., Gui, J.F., Mei, J. (2015) A feedback regulatory loop involving p53/miR-200 and growth hormone endocrine axis controls embryo size of zebrafish. Scientific Reports. 5:15906

Li, W.H., Zhou, L., Li, Z., Wang, Y., Shi, J.T., Yang, Y.J., Gui, J.F. (2015) Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation. International journal of biological sciences. 11(6):688-700

Feng, H., Zhang, Y., Zhang, Q., Li, Z., Zhang, Q., Gui, J. (2015) Zebrafish IRF1 Regulates IFN Antiviral Response through Binding to IFNϕ1 and IFNϕ3 Promoters Downstream of MyD88 Signaling. Journal of immunology (Baltimore, Md. : 1950). 194(3):1225-38

Wang, Y., Li, W.H., Li, Z., Liu, W., Zhou, L., Gui, J.F. (2015) BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development. Gene. 554:196-204

Xiao, Q., Xia, J.H., Zhang, X.J., Li, Z., Wang, Y., Zhou, L., Gui, J.F. (2014) Type-IV Antifreeze Proteins are Essential for Epiboly and Convergence in Gastrulation of Zebrafish Embryos. International journal of biological sciences. 10:715-32

Wang, Y., Sun, Z.H., Zhou, L., Li, Z., Gui, J.F. (2014) Grouper tshbeta Promoter-Driven Transgenic Zebrafish Marks Proximal Kidney Tubule Development. PLoS One. 9:e97806

Chen, S.Y., Shih, H.Y., Lin, S.J., Hsiao, C.D., Li, Z.C., and Cheng, Y.C. (2013) Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives. Journal of Cell Science. 126(Pt 24):5626-34

Li, Z.H., Xu, H., Zheng, W., Lam, S.H., and Gong, Z. (2013) RNA-Sequencing Analysis of TCDD-Induced Responses in Zebrafish Liver Reveals High Relatedness to In Vivo Mammalian Models and Conserved Biological Pathways. PLoS One. 8(10):e77292

Wang, R., Li, Z., Wang, Y., and Gui, J.F. (2011) An apo-14 promoter-driven transgenic zebrafish that marks liver organogenesis. PLoS One. 6(7):e22555

Mei, J., Liu, S., Li, Z., and Gui, J.F. (2010) Mtmr8 is essential for vasculature development in zebrafish embryos. BMC Developmental Biology. 10:96

Liu, S., Li, Z., and Gui, J.F. (2009) Fish-specific duplicated dmrt2b contributes to a divergent function through Hedgehog pathway and maintains left-right asymmetry establishment function. PLoS One. 4(9):e7261

Mei, J., Li, Z., and Gui, J.F. (2009) Cooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development in zebrafish. PLoS One. 4(3):e4979

Li, Z., and Chang, Y. (2007) V(D)J recombination in zebrafish: Normal joining products with accumulation of unresolved coding ends and deleted signal ends. Molecular immunology. 44(7):1804-1813