ZFIN ID: ZDB-LAB-170208-18
Hui Xu Lab
PI/Director: Xu, Hui
Contact Person: Xu, Hui
Email: huixu82@126.com
URL: http://nrl.ntu.edu.cn/sjkxx/xsdw/content/e2fc5b5d-20fd-4b9f-89b4-9bd74c106097.html
Address: Room 108 Building 8 Key Lab of Neuroregeneration of Jiangsu and Ministry of Education, Nantong University, 19# Qixiu Rd, Nantong, Jiangsu Province, China, 226001
Country: China
Phone: +86-513-85051593
Fax: +86-513-85511585
Line Designation: ntu

Show all 1 genomic features

We are interested in the phenomenon that some lower vertebrates such as fish and amphibians can regenerate their damaged retina. Currently we use zebrafish as a model system to investigate the cellular and molecular mechanisms underlying retinal regeneration. We are particularly interested in how injury signals promote the dedifferentiation and proliferation of Muller glia, and how their daughter progenitor cells migrate and differentiate into newborn retinal neurons. We are also interested in the development of eye and retina.

Hou, Haitao Graduate Student Kong, Yanan Graduate Student Lu, Ying Graduate Student
Zhang, Zhiqiang Graduate Student Zhou, Tianqiu Graduate Student Zhou, Ya Graduate Student
Zhang, Shuqiang Research Staff

Luo, J., Zhang, M., Chen, Y., Zhang, G., Zhou, T., Kang, L., Chen, X., Guan, H. (2024) Comprehensive analysis of the miRNA-mRNA regulatory network involved in spontaneous recovery of an H2O2-induced zebrafish cataract model. Experimental Eye Research. 240:109820
Song, K., Lin, Z., Cao, L., Lu, B., Chen, Y., Zhang, S., Lu, J., Xu, H. (2023) Sox11b regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish. Neural regeneration research. 18:445-450
Zhou, C., Zhang, X., Chen, Y., Lin, Z., Zhang, S., Zhang, Z., Cao, L., Guan, H., Lu, J., Xu, H. (2022) Context-dependent effects of inflammation on retina regeneration. Molecular neurobiology. 59(7):4351-4367
Zhou, T., Zhang, J., Qin, B., Xu, H., Zhang, S., Guan, H. (2020) Long non‑coding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR‑4728‑5p/OGG1 axis. International journal of molecular medicine. 46:1838-1848
Zhang, Z., Hou, H., Yu, S., Zhou, C., Zhang, X., Li, N., Zhang, S., Song, K., Lu, Y., Liu, D., Lu, H., Xu, H. (2019) Inflammation-induced mammalian target of rapamycin signaling is essential for retina regeneration. Glia. 68(1):111-127
Tang, M., Lu, Y., Xiong, Z., Chen, M., Qin, Y. (2019) The Grass Carp Genomic Visualization Database (GCGVD): an informational platform for genome biology of grass carp. International journal of biological sciences. 15:2119-2127
Wu, M., Zhang, S., Chen, X., Xu, H., Li, X. (2018) Expression and function of lncRNA MALAT-1 in the embryonic development of zebrafish. Gene. 680:65-71
Wang, X., Hou, H., Song, K., Zhang, Z., Zhang, S., Cao, Y., Chen, L., Sang, Q., Lin, F., Xu, H. (2018) Lpar2b Controls Lateral Line Tissue Size by Regulating Yap1 Activity in Zebrafish. Frontiers in molecular neuroscience. 11:34
Ke, W., Ye, D., Mersch, K., Xu, H., Chen, S., Lin, F. (2017) Gβ1 is required for neutrophil migration in zebrafish. Developmental Biology. 428(1):135-147
Mu, Z., Zhang, S., He, C., Hou, H., Liu, D., Hu, N., Xu, H. (2017) Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration. Neuroscience Bulletin. 33(1):53-61
Zhang, S., Mu, Z., He, C., Zhou, M., Liu, D., Zhao, X.F., Goldman, D., Xu, H. (2016) Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia-Derived Progenitors During Zebrafish Retinal Regeneration. Investigative ophthalmology & visual science. 57:1991-2000
Xu, H., Ye, D., Behra, M., Burgess, S., Chen, S., and Lin, F. (2014) Gbeta1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Developmental Biology. 385(2):316-27
Xu, H., Kardash, E., Chen, S., Raz, E., and Lin, F. (2012) Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Development (Cambridge, England). 139(1):57-62
Xu, H., Echemendia, N., Chen, S., and Lin, F. (2011) Identification and expression patterns of members of the protease-activated receptor (par) gene family during zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(1):278-287
Xu, H., Yang, J., Wang, Y., Jiang, Q., Chen, H., and Song, H. (2008) Exposure to 17α-ethynylestradiol impairs reproductive functions of both male and female zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 88(1):1-8