ZFIN ID: ZDB-LAB-160602-1
Melody Huang Lab
PI/Director: Huang, Melody Ying-Yu
Contact Person: Huang, Melody Ying-Yu
Email: Ying-Yu.Huang@usz.ch
URL: http://www.vertigocenter.ch/lab/FishLab.html
Address: Department of Neurology University Hospital Zurich Frauenklinikstrasse 26 CH-8091 Zürich Switzerland
Country: Switzerland
Phone: +41 (0)44 255 91 58
Fax: +41 (0)44 255 45 33
Line Designation: None assigned


We have been conducting translational research using zebrafish and human models in the field of clinical neuroscience. Being interested in the eyes and the brain, we focus on research questions with both physiological and behavioral aspects. We look at different sensory-motor systems and their interaction in diseased and healthy subjects. Besides studying ocular motor disorders, we are developing novel learning paradigms in zebrafish, aiming to study cognitive functioning and eventually screen for potential pharmacological treatment for the restoration of memory in patients with either brain injury-induced or age-related degeneration.

Bögli, Stefan Graduate Student Engerberg, Sandra Graduate Student Lin, Ting-Feng Graduate Student
Lüthi, Dennis Graduate Student Romano, Fausto Graduate Student Sun, Yongmei Graduate Student
Penner, Marco Technical Staff Mohamed, Ahmed Pul, Duygu

Lin, T.F., Huang, M.Y. (2023) A quantitative approach to study the adaptation of rhythmic eye movements and the resulting tonic eye deviation in larval zebrafish. Journal of neuroscience research. 101(9):1504-1518
Beppi, C., Penner, M., Straumann, D., Bögli, S.Y. (2023) Biomechanical induction of mild brain trauma in larval zebrafish: effects on visual startle reflex habituation. Brain communications. 5:fcad062fcad062
Lin, T.F., Mohammadi, M., Cullen, K.E., Chacron, M.J., Huang, M.Y. (2022) Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium. iScience. 25:105335
Beppi, C., Penner, M., Straumann, D., Bögli, S.Y. (2022) A non-invasive biomechanical model of mild TBI in larval zebrafish. PLoS One. 17:e0268901
Beppi, C., Beringer, G., Straumann, D., Bögli, S.Y. (2021) Light-stimulus intensity modulates startle reflex habituation in larval zebrafish. Scientific Reports. 11:22410
Hamanaka, K., Imagawa, E., Koshimizu, E., Miyatake, S., Tohyama, J., Yamagata, T., Miyauchi, A., Ekhilevitch, N., Nakamura, F., Kawashima, T., Goshima, Y., Mohamed, A.R., Ch'ng, G.S., Fujita, A., Azuma, Y., Yasuda, K., Imamura, S., Nakashima, M., Saitsu, H., Mitsuhashi, S., Mizuguchi, T., Takata, A., Miyake, N., Matsumoto, N. (2020) De Novo Truncating Variants in the Last Exon of SEMA6B Cause Progressive Myoclonic Epilepsy. American journal of human genetics. 106(4):549-558
Lin, T.F., Mohammadi, M., Fathalla, A.M., Pul, D., Lüthi, D., Romano, F., Straumann, D., Cullen, K.E., Chacron, M.J., Huang, M.Y. (2019) Negative optokinetic afternystagmus in larval zebrafish demonstrates set-point adaptation. Scientific Reports. 9:19039
Bögli, S.Y., Afthinos, M., Huang, M.Y. (2017) Effect of Gabapentin/Memantine on the Infantile Nystagmus Syndrome in the Zebrafish Model: Implications for the Therapy of Ocular Motor Diseases. Investigative ophthalmology & visual science. 58:3149-3157
Bögli, S.Y., Huang, M.Y. (2017) Spontaneous alternation behavior in larval zebrafish. The Journal of experimental biology. 220(Pt 2):171-173
Chen, C.C., Bockisch, C.J., Straumann, D., Huang, M.Y. (2016) Saccadic and Postsaccadic Disconjugacy in Zebrafish Larvae Suggests Independent Eye Movement Control. Frontiers in Systems Neuroscience. 10:80
Bögli, S.Y., Afthinos, M., Bertolini, G., Straumann, D., Huang, M.Y. (2016) Unravelling Stimulus Direction Dependency of Visual Acuity in Larval Zebrafish by Consistent Eye Displacements Upon Optokinetic Stimulation. Investigative ophthalmology & visual science. 57:1721-1727
Huber-Reggi, S.P., Mueller, K., Straumann, D., Huang, M.Y., Neuhauss, S.C. (2014) Individual Larvae of the Zebrafish Mutant belladonna Display Multiple Infantile Nystagmus-like Waveforms that Are Influenced by Viewing Conditions. Investigative ophthalmology & visual science. 55(6):3971-8
Chen, C.C., Bockisch, C.J., Olasagasti, I., Weber, K.P., Straumann, D., Huang, M.Y. (2014) Positive or negative feedback of optokinetic signals: degree of the misrouted optic flow determines system dynamics of human ocular motor behavior. Investigative ophthalmology & visual science. 55:2297-306
Chen, C.C., Bockisch, C.J., Bertolini, G., Olasagasti, I., Neuhauss, S.C., Weber, K.P., Straumann, D., and Huang, M.Y. (2014) Velocity storage mechanism in zebrafish larvae. The Journal of physiology. 592(Pt 1):203-14
Huber-Reggi, S.P., Chen, C.C., Grimm, L., Straumann, D., Neuhauss, S.C., and Huang, M.Y. (2012) Severity of Infantile Nystagmus Syndrome-Like Ocular Motor Phenotype Is Linked to the Extent of the Underlying Optic Nerve Projection Defect in Zebrafish belladonna Mutant. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(50):18079-18086
Huang, Y.Y., Haug, M.F., Gesemann, M., and Neuhauss, S.C. (2012) Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. PLoS One. 7(4):e35256
Huang, M., Chen, C.C., Huber-Reggi, S.P., Neuhauss, S.C., and Straumann, D. (2011) Comparison of infantile nystagmus syndrome in achiasmatic zebrafish and humans. Annals of the New York Academy of Sciences. 1233(1):285-291
Maurer, C.M., Huang, Y.Y., and Neuhauss, S.C. (2011) Application of zebrafish oculomotor behavior to model human disorders. Reviews in the Neurosciences. 22(1):5-16
Huang, Y.Y., Tschopp, M., Straumann, D., and Neuhauss, S.C. (2010) Vestibular deficits do not underlie looping behavior in achiasmatic fish. Communicative & integrative biology. 3(4):379-381
Huang, Y.Y., Tschopp, M., and Neuhauss, S.C. (2009) Illusionary self-motion perception in zebrafish. PLoS One. 4(8):e6550
Huang, Y.Y., and Neuhauss, S.C. (2008) The optokinetic response in zebrafish and its applications. Frontiers in bioscience : a journal and virtual library. 13(1):1899-1916
Huang, Y.Y., Rinner, O., Hedinger, P., Liu, S.C., and Neuhauss, S.C. (2006) Oculomotor instabilities in zebrafish mutant belladonna: a behavioral model for congenital nystagmus caused by axonal misrouting. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(39):9873-9880