ZFIN ID: ZDB-LAB-160517-1
Siegfried Lab
PI/Director: Siegfried, Kellee
Contact Person: Siegfried, Kellee
Email: Kellee.Siegfried@umb.edu
Address: University of Massachusetts Boston Biology Department 100 Morrissey Blvd. Boston, MA 02125
Country: United States
Phone: 617-287-6662
Fax: 617-287-6650
Line Designation: umb

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The Siegfried lab is interested in processes governing germ cell development and sex-determination in zebrafish.

Steinfeld, Jocelyn Graduate Student

Islam, K.N., Modi, M.M., Siegfried, K.R. (2021) The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I. Frontiers in cell and developmental biology. 9:714245
Han, D., Owiredu, J.N., Healy, B.M., Li, M., Labaf, M., Steinfeld, J.S., Patalano, S., Gao, S., Liu, M., Macoska, J.A., Zarringhalam, K., Siegfried, K.R., Yuan, X., Rebbeck, T.R., Cai, C. (2021) Susceptibility-Associated Genetic Variation in NEDD9 Contributes to Prostate Cancer Initiation and Progression. Cancer research. 81:3766-3776
Siegfried, K.R., Steinfeld, J.S. (2021) Histological Analysis of Gonads in Zebrafish. Methods in molecular biology (Clifton, N.J.). 2218:253-263
Webster, K.A., Henke, K., Ingalls, D.M., Nahrin, A., Harris, M.P., Siegfried, K.R. (2019) Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germ line of zebrafish. Reproduction (Cambridge, England). 157(4):383-398
Siegfried, K.R. (2019) It starts at the ends: The zebrafish meiotic bouquet is where it all begins. PLoS Genetics. 15:e1007854
Sosnik, J., Vieira, W.A., Webster, K.A., Siegfried, K.R., McCusker, C.D. (2017) A new and improved algorithm for the quantification of chromatin condensation from microscopic data shows decreased chromatin condensation in regenerating axolotl limb cells. PLoS One. 12:e0185292
Webster, K.A., Schach, U., Ordaz, A., Steinfeld, J.S., Draper, B.W., Siegfried, K.R. (2017) Dmrt1 is necessary for male sexual development in zebrafish. Developmental Biology. 422(1):33-46
Kawasaki, T., Siegfried, K.R., Sakai, N. (2016) Differentiation of zebrafish spermatogonial stem cells to functional sperm in culture. Development (Cambridge, England). 143(4):566-74
Fechner, S., Alvarez, L., Bönigk, W., Müller, A., Berger, T., Pascal, R., Trötschel, C., Poetsch, A., Stölting, G., Siegfried, K.R., Kremmer, E., Seifert, R., Kaupp, U.B. (2015) A K(+)-selective CNG channel orchestrates Ca2(+) signalling in zebrafish sperm. eLIFE. 4
Bowen, M.E., Henke, K., Siegfried, K.R., Warman, M.L., and Harris, M.P. (2012) Efficient Mapping and Cloning of Mutations in Zebrafish by Low-Coverage Whole-Genome Sequencing. Genetics. 190(3):1017-1024
Liew, W.C., Bartfai, R., Lim, Z., Sreenivasan, R., Siegfried, K.R., and Orban, L. (2012) Polygenic sex determination system in zebrafish. PLoS One. 7(4):e34397
Saito, K., Siegfried, K.R., Nüsslein-Volhard, C., and Sakai, N. (2011) Isolation and cytogenetic characterization of zebrafish meiotic prophase I mutants. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(7):1779-92
Siegfried, K.R., and Nüsslein-Volhard, C. (2008) Germ line control of female sex determination in zebrafish. Developmental Biology. 324(2):277-287