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Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-150413-1
The Wang Laboratory
PI/Director: Wang, Han
Co-PI / Senior
Researcher:
Liu, Chao
Sun, Yi
Zhong, Yingbin
Contact Person: Hu, Yingying
Email: huyingying860817@163.com
URL:
Address: Center for Circadian Clocks Soochow University 199 Renai Road Suzhou, Jiangsu, 215123 China
Country: China
Phone: 86 512 65881257
Fax: 86 512 65882115
Line Designation: sus


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 13 genomic features


STATEMENT OF RESEARCH INTERESTS
Most organisms display daily changes at molecular, cellular, physiological, and behavioral levels, which are known as circadian rhythms. The circadian clock controls fundamental life processes such as the human sleep-wake cycle. Many human sleep disorders and dysrhythmias are thought to result from circadian defects. A full molecular genetic understanding of circadian rhythmicity is critical for diagnosis, prevention and treatment of human dysrhythmias. We study molecular genetic mechanisms underlying zebrafish circadian rhythmicity. Using TALEN and CRISPR-Cas9 techniques, we have generated a number of mutants for zebrafish circadian clock genes. The roles of these circadian clock genes in the circadian system and life processes are investigated.

We also used zebrafish to study a group of human diseases called porphyria, derived from defective enzymes in heme biosynthesis. We have established several zebrafish models for human porphyria. We are interested in studying novel aspects of porphyria pathogenesis.


LAB MEMBERS
Liu, Taole Post-Doc Wang, Mingyong Post-Doc Deng, Bo Graduate Student
He, Wei Graduate Student Huang, Guodong Graduate Student Liu, Huazhen Graduate Student
Niu, Pengfei Graduate Student Niu, Zhijie Graduate Student Wang, Jingjing Graduate Student
Wang, Tuoyi Graduate Student Xu, Shuhao Graduate Student Yang, Fan Graduate Student
Ye, Qiang Graduate Student Yuan, Shiyu Graduate Student Zhang, Fanmiao Graduate Student
Zhang, Jiguang Graduate Student Zhang, Shuqing Graduate Student Zhang, Wei Graduate Student
Hu, Jia Technical Staff Zhong, Zhaomin Technical Staff Hu, Yingying Administrative Staff
Huang, Jian Ji, Cheng


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Zhou, J., Zhao, H., Zhang, L., Liu, C., Feng, S., Ma, J., Li, Q., Ke, H., Wang, X., Liu, L., Liu, C., Su, X., Liu, Y., Yang, S. (2019) Integrated analysis of RNA-seq and microRNA-seq depicts miRNA-mRNA networks involved in stripe patterns of Botia superciliaris skin. Functional & integrative genomics. 19(5):827-838
Tian, J., Hu, J., Liu, G., Yin, H., Chen, M., Miao, P., Bai, P., Yin, J. (2019) Corrigendum to "Altered gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots"[Environ. Pollut. 244 (2019) 588-599]. Environmental pollution (Barking, Essex : 1987). 245:1136
Zheng, Y., Liu, C., Li, Y., Jiang, H., Yang, P., Tang, J., Xu, Y., Wang, H., He, Y. (2018) Loss-of-function mutations with circadian rhythm regulator Per1/Per2 lead to premature ovarian insufficiency. Biology of reproduction. 100(4):1066-1072
Tian, J., Hu, J., Liu, G., Yin, H., Chen, M., Miao, P., Bai, P., Yin, J. (2018) Altered Gene expression of ABC transporters, nuclear receptors and oxidative stress signaling in zebrafish embryos exposed to CdTe quantum dots. Environmental pollution (Barking, Essex : 1987). 244:588-599
Wang, T., Liu, Y., Liu, H., Li, C., Wang, Y. (2018) Auriculasin from Flemingia philippinensis roots shows good therapeutic indexes on hyperactive behavior in zebrafish. Biochemical and Biophysical Research Communications. 503(3):1254-1259
Jia, R., Song, P., Wang, J., Mai, H., Li, S., Cheng, Y., Wu, S. (2018) Self-Assembled Fluorescent Nanoprobe Based on Forster Resonance Energy Transfer for Carbon Monoxide in Living Cells and Animals via Ligand Exchange. Analytical chemistry. 90(12):7117-7121
He, H., Wang, C., Tang, Q., Yang, F., Xu, Y. (2018) Possible mechanisms of prednisolone-induced osteoporosis in zebrafish larva. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 101:981-987
Huang, D.F., Wang, M.Y., Yin, W., Ma, Y.Q., Wang, H., Xue, T., Ren, D.L., Hu, B. (2018) Zebrafish Lacking Circadian Gene per2 Exhibit Visual Function Deficiency.. Frontiers in behavioral neuroscience. 12:53
He, H., Wang, C., Tang, Q., Yang, F., Xu, Y. (2018) Elucidation of possible molecular mechanisms underlying the estrogen-induced disruption of cartilage development in zebrafish larvae. Toxicology letters. 289:22-27
Zhong, Y., Ye, Q., Chen, C., Wang, M., Wang, H. (2018) Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish. Nucleic acids research. 46(7):3382-3399
Liu, C., Kim, Y.S., Kim, J., Pattison, J., Kamaid, A., Miller, Y.I. (2017) Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish. Journal of Lipid Research. 59(2):391-399
Nie, K., Wang, K., Huang, D.F., Huang, Y.B., Yin, W., Ren, D.L., Wang, H., Hu, B. (2017) Effects of circadian clock protein Per1b on zebrafish visual functions. Chronobiology International. 35(2):160-168
Han, J., Ji, C., Guo, Y., Yan, R., Hong, T., Dou, Y., An, Y., Tao, S., Qin, F., Nie, J., Ji, C., Wang, H., Tong, J., Xiao, W., Zhang, J. (2017) Mechanisms underlying melatonin-mediated prevention of fenvalerate-induced behavioral and oxidative toxicity in zebrafish. Journal of toxicology and environmental health. Part A. 80(23-24):1331-1341
Yue, C., Ji, C., Zhang, H., Zhang, L.W., Tong, J., Jiang, Y., Chen, T. (2017) Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/β-catenin signal pathways. Environmental toxicology. 32(10):2316-2322
Yao, Y., Sun, S., Fei, F., Wang, J., Wang, Y., Zhang, R., Wu, J., Liu, L., Liu, X., Cui, Z., Li, Q., Yu, M., Dang, Y., Wang, X. (2017) Screening in larval zebrafish reveals tissue-specific distributions of fifteen fluorescent compounds. Disease models & mechanisms. 10(9):1155-1164
Ren, D.L., Ji, C., Wang, X.B., Wang, H., Hu, B. (2017) Endogenous melatonin promotes rhythmic recruitment of neutrophils toward an injury in zebrafish. Scientific Reports. 7:4696
Xiao, B., Cui, L.Q., Ding, C., Wang, H. (2017) Effects of Lithium and 2,4-Dichlorophenol on Zebrafish: Circadian Rhythm Disorder and Molecular Effects. Zebrafish. 14(3):209-215
Tian, J., Hu, J., Chen, M., Yin, H., Miao, P., Bai, P., Yin, J. (2017) The use of mrp1-deficient (Danio rerio) zebrafish embryos to investigate the role of Mrp1 in the toxicity of cadmium chloride and benzo[a]pyrene. Aquatic toxicology (Amsterdam, Netherlands). 186:123-133
Hua, Y., Wang, C., Huang, J., Wang, K. (2017) A simple and efficient method for CRISPR/Cas9-induced mutant screening. Journal of genetics and genomics = Yi chuan xue bao. 44(4):207-213
Macia, M.S., Halbritter, J., Delous, M., Bredrup, C., Gutter, A., Filhol, E., Mellgren, A.E., Leh, S., Bizet, A., Braun, D.A., Gee, H.Y., Silbermann, F., Henry, C., Krug, P., Bole-Feysot, C., Nitschké, P., Joly, D., Nicoud, P., Paget, A., Haugland, H., Brackmann, D., Ahmet, N., Sandford, R., Cengiz, N., Knappskog, P.M., Boman, H., Linghu, B., Yang, F., Oakeley, E.J., Saint Mézard, P., Sailer, A.W., Johansson, S., Rødahl, E., Saunier, S., Hildebrandt, F., Benmerah, A. (2017) Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. American journal of human genetics. 100:1-11
Liu, C., Gaudet, D., Miller, Y.I. (2017) Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. PLoS One. 12:e0169939
Zhong, Y., Duan, C. (2017) Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Frontiers in endocrinology. 7:174
Yang, J., Pei, H., Luo, H., Fu, A., Yang, H., Hu, J., Zhao, C., Chai, L., Chen, X., Shao, X., Wang, C., Wu, W., Wan, L., Ye, H., Qiu, Q., Peng, A., Wei, Y., Yang, L., Chen, L. (2017) Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways. Oncotarget. 8(1):915-932
Wang, Y., Liu, W., Yang, J., Wang, F., Yizhen, S., Zhong, Z.M., Wang, H., Hu, L.F., Liu, C.F. (2017) Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish. Neurotoxicology. 58:103-109
Xiao, B., Chen, T.M., Zhong, Y. (2016) Possible molecular mechanism underlying cadmium-induced circadian rhythms disruption in zebrafish. Biochemical and Biophysical Research Communications. 481(3-4):201-205
Manalo, T., May, A., Quinn, J., Lafontant, D.S., Shifatu, O., He, W., Gonzalez-Rosa, J.M., Burns, G.C., Burns, C.E., Burns, A.R., Lafontant, P.J. (2016) Differential Lectin Binding Patterns Identify Distinct Heart Regions in Giant Danio (Devario aequipinnatus) and Zebrafish (Danio rerio) Hearts. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 64(11):687-714
Pei, S., Liu, L., Zhong, Z., Wang, H., Lin, S., Shang, J. (2016) Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluoxetine. Scientific Reports. 6:33822
Li, W., Zheng, N.Z., Yuan, Q., Xu, K., Yang, F., Gu, L., Zheng, G.Y., Luo, G.J., Fan, C., Ji, G.J., Zhang, B., Cao, H., Tian, X.L. (2016) NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. Journal of molecular medicine (Berlin, Germany). 94(9):993-1002
Huang, G., Zhang, F., Ye, Q., Wang, H. (2016) The circadian clock regulates autophagy directly through the nuclear hormone receptor Nr1d1/Rev-erbα and indirectly via Cebpb/(C/ebpβ) in zebrafish. Autophagy. 12(8):1292-309
Bo, L., Liu, Z., Zhong, Y., Huang, J., Chen, B., Wang, H., Xu, Y. (2016) Iron deficiency anemia's affect on bone formation in zebrafish mutant. Biochemical and Biophysical Research Communications. 475(3):271-6
Kuang, X., Liu, C., Fang, J., Ma, W., Zhang, J., Cui, S. (2016) The tumor suppressor gene lkb1 is essential for glucose homeostasis during zebrafish early development. FEBS letters. 590(14):2076-85
Zhang, Y., Zhang, Y., Chen, A., Zhang, W., Chen, H., Zhang, Q. (2016) Enantioselectivity in Developmental Toxicity of rac-metalaxyl and R-metalaxyl in Zebrafish (Danio rerio) Embryo. Chirality. 28(6):489-94
Yang, F., Gao, C., Wang, P., Zhang, G.J., Chen, Z. (2016) Fish-on-a-chip: microfluidics for zebrafish research. Lab on a Chip. 16(7):1106-25
Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
Dana, H., Mohar, B., Sun, Y., Narayan, S., Gordus, A., Hasseman, J.P., Tsegaye, G., Holt, G.T., Hu, A., Walpita, D., Patel, R., Macklin, J.J., Bargmann, C.I., Ahrens, M.B., Schreiter, E.R., Jayaraman, V., Looger, L.L., Svoboda, K., Kim, D.S. (2016) Sensitive red protein calcium indicators for imaging neural activity. eLIFE. 5
Ma, J.F., Yang, F., Mahida, S.N., Zhao, L., Chen, X., Zhang, M.L., Sun, Z., Yao, Y., Zhang, Y.X., Zheng, G.Y., Dong, J., Feng, M.J., Zhang, R., Sun, J., Li, S., Wang, Q.S., Cao, H., Benjamin, E.J., Ellinor, P.T., Li, Y.G., Tian, X.L. (2016) TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians. Cardiovascular research. 109(3):442-50
Wang, Y., Li, S., Liu, W., Wang, F., Hu, L.F., Zhong, Z.M., Wang, H., Liu, C.F. (2016) Vesicular Monoamine Transporter 2 (Vmat2)knockdown elicits anxiety-like behavior in zebrafish. Biochemical and Biophysical Research Communications. 470(4):792-7
Sheng, L., Wang, L., Zhao, X., Hu, R., Yu, X., Hong, J., Liu, D., Xu, B., Zhu, Y., Wang, H., Hong, F. (2016) Mechanism of TiO2 nanoparticle-induced neurotoxicity in zebrafish (Danio rerio). Environmental toxicology. 31(2):163-75
Zhang, J., Sun, P., Kong, T., Yang, F., Guan, W. (2016) Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved. Aquatic toxicology (Amsterdam, Netherlands). 170:208-215
Bizet, A.A., Becker-Heck, A., Ryan, R., Weber, K., Filhol, E., Krug, P., Halbritter, J., Delous, M., Lasbennes, M.C., Linghu, B., Oakeley, E.J., Zarhrate, M., Nitschké, P., Garfa-Traore, M., Serluca, F., Yang, F., Bouwmeester, T., Pinson, L., Cassuto, E., Dubot, P., Elshakhs, N.A., Sahel, J.A., Salomon, R., Drummond, I.A., Gubler, M.C., Antignac, C., Chibout, S., Szustakowski, J.D., Hildebrandt, F., Lorentzen, E., Sailer, A.W., Benmerah, A., Saint-Mezard, P., Saunier, S. (2015) Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nature communications. 6:8666
Sun, Y., Sheng, Z., Ma, C., Tang, K., Zhu, R., Wu, Z., Shen, R., Feng, J., Wu, D., Huang, D., Huang, D., Fei, J., Liu, Q., Cao, Z. (2015) Combining genomic and network characteristics for extended capability in predicting synergistic drugs for cancer. Nature communications. 6:8481
Liu, F., Xia, W., Hu, J., Wang, Y., Yang, F., Sun, S., Zhang, J., Jiang, N., Wang, H., Tian, W., Wang, X., Ma, D. (2015) Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish. PLoS One. 10:e0136832
Wang, F., Huang, G.D., Tian, H., Zhong, Y.B., Shi, H.J., Li, Z., Zhang, X.S., Wang, H., Sun, F. (2015) Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype. Scientific Reports. 5:13050
Ren, D.L., Li, Y.J., Hu, B.B., Wang, H., Hu, B. (2015) Melatonin regulates the rhythmic migration of neutrophils in live zebrafish. Journal of pineal research. 58(4):452-60
Xu, Y., Cao, J., Huang, S., Feng, D., Zhang, W., Zhu, X., Yan, X. (2015) Characterization of Tetratricopeptide Repeat-Containing Proteins Critical for Cilia Formation and Function. PLoS One. 10:e0124378
Li, Y., Yang, X., Chen, Z., Zhang, B., Pan, J., Li, X., Yang, F., Sun, D. (2015) Comparative toxicity of lead (Pb(2+)), copper (Cu(2+)), and mixtures of lead and copper to zebrafish embryos on a microfluidic chip. Biomicrofluidics. 9:024105
Fosque, B.F., Sun, Y., Dana, H., Yang, C.T., Ohyama, T., Tadross, M.R., Patel, R., Zlatic, M., Kim, D.S., Ahrens, M.B., Jayaraman, V., Looger, L.L., Schreiter, E.R. (2015) Labeling of active neural circuits in vivo with designed calcium integrators. Science (New York, N.Y.). 347:755-760
Wang, M., Zhong, Z., Zhong, Y., Zhang, W., Wang, H. (2015) The Zebrafish Period2 Protein Positively Regulates the Circadian Clock through Mediation of Retinoic Acid Receptor (RAR)-related Orphan Receptor α (Rorα). The Journal of biological chemistry. 290(7):4367-4382
Huang, J., Zhong, Z., Wang, M., Chen, X., Tan, Y., Zhang, S., He, W., He, X., Huang, G., Lu, H., Wu, P., Che, Y., Yan, Y.L., Postlethwait, J.H., Chen, W., Wang, H. (2015) Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:2572-87
Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P., Zhong, Z., Hong, F., Wang, G., Postlethwait, J.H., Wang, H. (2015) Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Scientific Reports. 5:8113
Liu, F., Yang, F., Wen, D., Xia, W., Hao, L., Hu, J., Zong, J., Shen, X., Ma, J., Jiang, N., Sun, S., Zhang, J., Wang, H., Wang, X., Ma, Z., Ma, D. (2015) Grhl1 deficiency affects inner ear development in zebrafish. The International journal of developmental biology. 59(10-11-12):417-423
Liu, S., Wang, M.X., Mao, C.J., Cheng, X.Y., Wang, C.T., Huang, J., Zhong, Z.M., Hu, W.D., Wang, F., Hu, L.F., Wang, H., Liu, C.F. (2014) Expression and functions of ASIC1 in the zebrafish retina. Biochemical and Biophysical Research Communications. 455(3-4):353-7
Li, J., Qi, M., Li, C., Shi, D., Zhang, D., Xie, D., Yuan, T., Feng, J., Liu, Y., Liang, D., Xu, X., Chen, J., Xu, L., Zhang, H., Ye, J., Lv, F., Huang, J., Peng, L., Chen, Y.H. (2014) Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy. Cell Research. 24:977-93
Zhang, S., Xu, M., Huang, J., Tang, L., Zhang, Y., Wu, J., Lin, S., and Wang, H. (2014) Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish. Disease models & mechanisms. 7(7):837-45
Li, Y., Yang, F., Chen, Z., Shi, L., Zhang, B., Pan, J., Li, X., Sun, D., Yang, H. (2014) Zebrafish on a chip: a novel platform for real-time monitoring of drug-induced developmental toxicity. PLoS One. 9:e94792
Chen, B., Yan, Y.L., Liu, C., Bo, L., Li, G.F., Wang, H., and Xu, Y.J. (2014) Therapeutic effect of deferoxamine on iron overload-induced inhibition of osteogenesis in a zebrafish model. Calcified tissue international. 94(3):353-360
Yang, F., Xiong, J., Jia, X.E., Gu, Z.H., Shi, J.Y., Zhao, Y., Li, J.M., Chen, S.J., Zhao, W.L. (2014) GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression. PLoS One. 9:e89302
Fang, L., Liu, C., and Miller, Y.I. (2014) Zebrafish models of dyslipidemia: relevance to atherosclerosis and angiogenesis. Translational research : the journal of laboratory and clinical medicine. 163(2):99-108
Ji, C. (2014) New Insights into the Pathogenesis of Alcohol-Induced ER Stress and Liver Diseases. International journal of hepatology. 2014:513787
Valvezan, A.J., Huang, J., Lengner, C.J., Pack, M., and Klein, P.S. (2014) Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1). Disease models & mechanisms. 7(1):63-71
Yang, J.H., Hu, J., Wan, L., and Chen, L.J. (2014) Barbigerone inhibits tumor angiogenesis, growth and metastasis in melanoma. Asian Pacific journal of cancer prevention : APJCP. 15(1):167-174
Zhang, W., Li, P., Yang, F., Hu, X., Sun, C., Zhang, W., Chen, D., and Tang, B. (2013) Dynamic and reversible fluorescence imaging of superoxide anion fluctuations in live cells and in vivo. Journal of the American Chemical Society. 135(40):14956-14959
Fang, L., Choi, S.H., Baek, J.S., Liu, C., Almazan, F., Ulrich, F., Wiesner, P., Taleb, A., Deer, E., Pattison, J., Torres-Vázquez, J., Li, A.C., and Miller, Y.I. (2013) Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 498(7452):118-122
Liu, C., Ma, W., Su, W., and Zhang, J. (2012) Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish. Development (Cambridge, England). 139(24):4591-4600
Zhang, X., Zhao, H., Chen, Y., Liu, C., Meng, K., Yang, P., Wang, Y., Wang, G., and Yao, B. (2012) Characterization and biological function analysis of the trim3a gene from zebrafish (Danio rerio). Fish & shellfish immunology. 32(5):621-628
Yang, F., Chen, Z., Pan, J., Li, X., Feng, J., and Yang, H. (2011) An integrated microfluidic array system for evaluating toxicity and teratogenicity of drugs on embryonic zebrafish developmental dynamics. Biomicrofluidics. 5(2):24115
Zhu, W., Fu, A., Hu, J., Wang, T., Luo, Y., Peng, M., Ma, Y., Wei, Y., and Chen, L. (2011) 5-formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway. Experimental & molecular medicine. 43(3):146-52
Yang, F., Zhang, Q., Guo, H., and Zhang, S. (2010) Evaluation of cytotoxicity, genotoxicity and teratogenicity of marine sediments from Qingdao coastal areas using in vitro fish cell assay, comet assay and zebrafish embryo test. Toxicology in vitro : an international journal published in association with BIBRA. 24(7):2003-2011
Wang, H. (2009) Comparative genomic analysis of teleost fish bmal genes. Genetica. 136(1):149-161
Wang, H. (2008) Comparative Analysis of Period Genes in Teleost Fish Genomes. Journal of molecular evolution. 67(1):29-40
Wang, H. (2008) Comparative analysis of teleost fish genomes reveals preservation of different ancient clock duplicates in different fishes. Marine genomics. 1(2):69-78
Wang, H., Kesinger, J.W., Zhou, Q., Wren, J.D., Martin, G., Turner, S., Tang, Y., Frank, M.B., and Centola, M. (2008) Identification and characterization of zebrafish ocular formation genes. Genome. 51(3):222-235
Sun, Y., Wang, J., Lao, H., Yin, Z., He, W., Weng, S., Yu, X., Chan, S., and He, J. (2008) Molecular cloning and expression analysis of the ASC gene from mandarin fish and its regulation of NF-kappaB activation. Developmental and comparative immunology. 32(4):391-399
Wang, H., Zhou, Q., Kesinger, J.W., Norris, C., and Valdez, C. (2007) Heme regulates exocrine peptidase precursor genes in zebrafish. Experimental Biology and Medicine. 232(9):1170-1180
Wang, H., Lee, E.M., Sperber, S.M., Lin, S., Ekker, M., and Long, Q. (2007) Isolation and expression of zebrafish zinc-finger transcription factor gene tsh1. Gene expression patterns : GEP. 7(3):318-322
Tucker, A.E., Salles, I.I., Voth, D.E., Ortiz-Leduc, W., Wang, H., Dozmorov, I., Centola, M., and Ballard, J.D. (2003) Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages. Cellular Microbiology. 5(8):523-532
Young, R.M., Marty, S., Nakano, Y., Wang, H., Yamamoto, D., Lin, S., and Allende, M.L. (2002) Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 223(2):298-305
Wang, H., Long, Q.M., Marty, S.D., Sassa, S., and Lin, S. (1998) A zebrafish model for hepatoerythropoietic porphyria. Nature Genetics. 20:239-243
Long, Q.M., Meng, A.M., Wang, H., Jessen, J.R., Farrell, M.J., and Lin, S. (1997) GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (Cambridge, England). 124(20):4105-4111