ZFIN ID: ZDB-LAB-150410-1
The Shah Laboratory
PI/Director: Shah, Dhvanit I.
Contact Person: Shah, Dhvanit I.
Email: dshah@research.bwh.harvard.edu
URL: http://www.shahlaboratory.org
Address: 1 Blackfan Circle, Karp 5th Floor, Boston MA 02115
Country: United States
Phone: 617-355-9=9042
Fax: 617-355-9064
Line Designation: None assigned


My laboratory investigates the origin, development, and differentiation of hematopoietic stem cells (HSCs) to treat patients with leukemia, lymphoma, genetic blood disorders, and bone-marrow failure syndromes. We have expertise in utilizing zebrafish, mice, and human induced pluripotent stem (iPS) cells to clone and analyze novel genes and mechanisms important for blood formation. Our goal is to utilize our knowledge in developing mechanism-based therapies as well as generating functional HSCs from patient-derived tissues for the treatment of hematological diseases using state-of-the-art gene-editing, cell-engineering, and computational approaches.

Patch, Taylor Administrative Staff

Hagedorn, E.J., Cillis, J.L., Curley, C.R., Patch, T.C., Li, B., Blaser, B.W., Riquelme, R., Zon, L.I., Shah, D.I. (2016) Generation of Parabiotic Zebrafish Embryos by Surgical Fusion of Developing Blastulae. Journal of visualized experiments : JoVE. (112)
Anderson, H., Patch, T.C., Reddy, P.N., Hagedorn, E.J., Kim, P.G., Soltis, K.A., Chen, M.J., Tamplin, O.J., Frye, M., MacLean, G.A., Hübner, K., Bauer, D.E., Kanki, J.P., Vogin, G., Huston, N.C., Nguyen, M., Fujiwara, Y., Paw, B.H., Vestweber, D., Zon, L.I., Orkin, S.H., Daley, G.Q., Shah, D.I. (2015) Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 126(26):2811-20
Yien, Y. Y., Robledo, R. F., Schultz, I. J., Takahashi-Makise, N., Gwynn, B., Bauer, D. E., Bass, A., Yi, G., Li, L., Hildick-Smith, G. J., Cooney, J. D., Pierce, E. L., Mohler, K., Dailey, T. A., Miyata, N., Kingsley, P. D., Garone, C., Hattangadi, S. M., Huang, H., Chen, W., Keenan, E. M., Shah, D. I., Schlaeger, T. M., DiMauro, S., Orkin, S. H., Cantor, A. B., Palis, J., Koehler, C. M., Lodish, H. F., Kaplan, J., Ward, D. M., Dailey, H. A., Phillips, J. D., Peters, L. L., Paw, B. H. (2014) TMEM14C is required for erythroid mitochondrial heme metabolism. The Journal of Clinical Investigation. 124(10):4294-4304
Hildick-Smith, G.J., Cooney, J.D., Garone, C., Kremer, L.S., Haack, T.B., Thon, J.N., Miyata, N., Lieber, D.S., Calvo, S.E., Akman, H.O., Yien, Y.Y., Huston, N.C., Branco, D.S., Shah, D.I., Freedman, M.L., Koehler, C.M., Italiano, J.E., Merkenschlager, A., Beblo, S., Strom, T.M., Meitinger, T., Freisinger, P., Donati, M.A., Prokisch, H., Mootha, V.K., Dimauro, S., and Paw, B.H. (2013) Macrocytic Anemia and Mitochondriopathy Resulting from a Defect in Sideroflexin 4. American journal of human genetics. 93(5):906-14
Chen, C., Garcia-Santos, D., Ishikawa, Y., Seguin, A., Li, L., Fegan, K.H., Hildick-Smith, G.J., Shah, D.I., Cooney, J.D., Chen, W., King, M.J., Yien, Y.Y., Schultz, I.J., Anderson, H., Dalton, A.J., Freedman, M.L., Kingsley, P.D., Palis, J., Hattangadi, S.M., Lodish, H.F., Ward, D.M., Kaplan, J., Maeda, T., Ponka, P., and Paw, B.H. (2013) Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation. Cell Metabolism. 17(3):343-352
Cooney, J.D., Hildick-Smith, G.J., Shafizadeh, E., McBride, P.F., Carroll, K.J., Anderson, H., Shaw, G.C., Tamplin, O.J., Branco, D.S., Dalton, A.J., Shah, D.I., Wong, C., Gallagher, P.G., Zon, L.I., North, T.E., and Paw, B.H. (2013) Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Developmental Biology. 373(2):431-441
Shah, D.I., Takahashi-Makise, N., Cooney, J.D., Li, L., Schultz, I.J., Pierce, E.L., Narla, A., Seguin, A., Hattangadi, S.M., Medlock, A.E., Langer, N.B., Dailey, T.A., Hurst, S.N., Faccenda, D., Wiwczar, J.M., Heggers, S.K., Vogin, G., Chen, W., Chen, C., Campagna, D.R., Brugnara, C., Zhou, Y., Ebert, B.L., Danial, N.N., Fleming, M.D., Ward, D.M., Campanella, M., Dailey, H.A., Kaplan, J., and Paw, B.H. (2012) Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature. 491:608-612
Amigo, J.D., Ackermann, G.E., Cope, J.J., Yu, M., Cooney, J.D., Ma, D., Langer, N.B., Shafizadeh, E., Shaw, G.C., Horsley, W., Trede, N.S., Davidson, A.J., Barut, B.A., Zhou, Y., Wojiski, S.A., Traver, D., Moran, T.B., Kourkoulis, G., Hsu, K., Kanki, J.P., Shah, D.I., Lin, H.F., Handin, R.I., Cantor, A.B., and Paw, B.H. (2009) The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood. 114(21):4654-4663