Yao Lab

We are interested in the function of epigenetic factors in human cancers. Increasing evidence shows that abnormalities in the epigenetic regulation of chromatin status caused by mutations, amplifications, deletions and rearrangements of genes encoding epigenetic regulators can lead to cancer. We are now using Talen, Cas9 and tol2 mediated transgene techniques in zebrafish to study several histone modifiers including NSD families and Ezh2.