ZFIN ID: ZDB-LAB-150205-1
Yao Lab
PI/Director: Yao, Shaohua
Contact Person: Yao, Shaohua
Email: shaohuayao@scu.edu.cn
Address: Sichuan University, 17# Renmin Nanlu, Wuhou District, Chengdu China, 610041
Country: China
Phone: 862885503328
Fax: 862885503328
Line Designation: scu

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We are interested in the function of epigenetic factors in human cancers. Increasing evidence shows that abnormalities in the epigenetic regulation of chromatin status caused by mutations, amplifications, deletions and rearrangements of genes encoding epigenetic regulators can lead to cancer. We are now using Talen, Cas9 and tol2 mediated transgene techniques in zebrafish to study several histone modifiers including NSD families and Ezh2.

Zhang, Ting Post-Doc Wang, Ping Graduate Student Yu, Chuan Graduate Student
Zhang, Yaguang Graduate Student Li, Xinyue Shang, Jinfeng

Sun, A., Xu, K., Liu, H., Li, H., Shi, Y., Zhu, X., Liang, T., Li, X., Cao, X., Ji, Y., Jiang, T., Xu, C., Liu, X. (2020) The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates. Scientific Reports. 10:4126
Zeng, A., Ye, T., Cao, D., Huang, X., Yang, Y., Chen, X., Xie, Y., Yao, S., Zhao, C. (2017) Identify a Blood-Brain Barrier Penetrating Drug-TNB using Zebrafish Orthotopic Glioblastoma Xenograft Model. Scientific Reports. 7:14372
Yu, C., Yao, X., Zhao, L., Wang, P., Zhang, Q., Zhao, C., Yao, S., Wei, Y. (2017) Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation. Neoplasia (New York, N.Y.). 19:606-616
Elsayed, M.S.A., Su, Y., Wang, P., Sethi, T., Agama, K., Ravji, A., Redon, C.E., Kiselev, E., Horzmann, K.A., Freeman, J.L., Pommier, Y., Cushman, M. (2017) Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I. Journal of medicinal chemistry. 60:5364-5376
Yao, X., Liu, X., Zhang, Y., Li, Y., Zhao, C., Yao, S., Wei, Y.Q. (2017) Gene Therapy of Adult Neuronal Ceroid Lipofuscinoses with CRISPR/Cas9 in Zebrafish. Human gene therapy. 28(7):588-597
Xiao, C., Qian, M., Yin, C., Zhang, Y., Hu, H., Yao, S. (2017) Erratum to: A zebrafish mosaic assay to study mammalian stem cells in real time in vivo. Journal of Molecular Histology.
Zhang, Y., Wang, P., Zhang, Q., Yao, X., Zhao, L., Liu, Y., Liu, X., Tao, R., Yu, C., Li, Y., Song, X., Yao, S. (2017) eIF3i activity is critical for endothelial cells in tumor induced angiogenesis through regulating VEGFR and ERK translation. Oncotarget. 8(12):19968-19979
Wei, Y., Li, K., Yao, S., Gao, J., Li, J., Shang, Y., Zhang, J., Zhang, L., Li, Y., Mo, X., Meng, W., Xiang, R., Hu, J., Lin, P., Wei, Y. (2016) Loss of ZNF32 augments the regeneration of nervous lateral line system through negative regulation of SOX2 transcription. Oncotarget. 7(43):70420-70436
Xiao, C., Qian, M., Yin, C., Zhang, Y., Hu, H., Yao, S. (2016) A zebrafish mosaic assay to study mammalian stem cells in real time in vivo. Journal of Molecular Histology. 47(5):437-44
Yang, F., Gao, C., Wang, P., Zhang, G.J., Chen, Z. (2016) Fish-on-a-chip: microfluidics for zebrafish research. Lab on a Chip. 16(7):1106-25
Zhang, T., Xu, L., Wu, J.J., Wang, W.M., Mei, J., Ma, X.F., Liu, J.X. (2015) Transcriptional responses and mechanisms of copper-induced dysfunctional locomotor behavior in zebrafish embryos. Toxicological sciences : an official journal of the Society of Toxicology. 148(1):299-310
Zhang, T., Zhou, X.Y., Ma, X.F., Liu, J.X. (2015) Mechanisms of cadmium-caused eye hypoplasia and hypopigmentation in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 167:68-76
Zhang, T., Yin, C., Qiao, L., Jing, L., Li, H., Xiao, C., Luo, N., Lei, S., Meng, W., Zhu, H., Liu, J., Xu, H., Mo, X. (2014) Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors. Development (Cambridge, England). 141:4332-42
Yuan, Y., Zhang, Y., Yao, S., Shi, H., Huang, X., Li, Y., Wei, Y., Lin, S. (2014) The translation initiation factor Eif3i upregulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis. The Journal of biological chemistry. 289(41):28310-23
Yu, C., Zhang, Y., Yao, S., Wei, Y. (2014) A PCR Based Protocol for Detecting Indel Mutations Induced by TALENs and CRISPR/Cas9 in Zebrafish. PLoS One. 9:e98282
Qiao, L., Gao, H., Zhang, T., Jing, L., Xiao, C., Xiao, Y., Luo, N., Zhu, H., Meng, W., Xu, H., Mo, X. (2014) Snail modulates the assembly of fibronectin via alpha5 integrin for myocardial migration in zebrafish embryos. Scientific Reports. 4:4470
Ge, L., Zhang, R.P., Wan, F., Guo, D.Y., Wang, P., Xiang, L.X., and Shao, J.Z. (2014) TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model. Molecular and cellular biology. 34(6):989-1002
Yang, X.Y., Zhou, X.Y., Wang, Q., Li, H., Chen, Y., Lei, Y.P., Ma, X.H., Kong, P., Shi, Y., Jin, L., Zhang, T., and Wang, H.Y. (2013) Mutations in the COPII Vesicle Component Gene SEC24B are Associated with Human Neural Tube Defects. Human Mutation. 34(8):1094-101
Wang, R., Wang, Y., Liu, N., Ren, C., Jiang, C., Zhang, K., Yu, S., Chen, Y., Tang, H., Deng, Q., Fu, C., Wang, Y., Li, R., Liu, M., Pan, W., and Wang, P. (2013) FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Research. 23(6):803-19
Zhang, T., and Mo, X.M. (2013) Zebra fish cell movements during gastrulation. Yi chuan = Hereditas. 35(4):441-448
Qian, M., Yao, S., Jing, L., He, J., Xiao, C., Zhang, T., Meng, W., Zhu, H., Xu, H., and Mo, X. (2013) ENC1-like Integrates the Retinoic Acid/FGF Signaling Pathways to Modulate Ciliogenesis of Kupffer's Vesicle during Zebrafish Embryonic Development. Developmental Biology. 374(1):85-95
Liu, F., Yao, S., Zhang, T., Xiao, C., Shang, Y., Liu, J., and Mo, X. (2012) Kzp Regulates the Transcription of gata2 and pu.1 During Primitive Hematopoiesis in Zebrafish Embryos. Journal of genetics and genomics = Yi chuan xue bao. 39(9):463-471
Zhang, T., Yao, S., Wang, P., Yin, C., Xiao, C., Qian, M., Liu, D., Zheng, L., Meng, W., Zhu, H., Liu, J., Xu, H., and Mo, X. (2011) APOA-II Directs Morphogenetic Movements of Zebrafish Embryo by Preventing Chromosome Fusion During Nuclear Division in Yolk Syncytial Layer. The Journal of biological chemistry. 286(11):9514-25
Yao, S., Qian, M., Deng, S., Xie, L., Yang, H., Xiao, C., Zhang, T., Xu, H., Zhao, X., Wei, Y.Q., and Mo, X. (2010) KZP controls canonical WNT8 signaling to modulate dorsoventral patterning during zebrafish gastrulation. The Journal of biological chemistry. 285(53):42086-42096
Yao, S., Xie, L., Qian, M., Yang, H., Zhou, L., Zhou, Q., Yan, F., Gou, L., Wei, Y., Zhao, X., and Mo, X. (2008) Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. FEBS letters. 582(15):2325-2332