ZFIN ID: ZDB-LAB-141112-1
Bovolenta Lab
PI/Director: Bovolenta, Paola
Co-PI / Senior
Cavodeassi, Florencia
Cubelos, Beatriz
Esteve, Pilar
Contact Person: Tabanera, Noemí
Email: ntabanera@cbm.csic.es
URL: http://web4.cbm.uam.es/joomla-rl/index.php/es/index.php?option=com_content&view=article&id=408
Address: Centro de Biología Molecular Severo Ochoa (CSIC-UAM) C/Nicolás Cabrera, 1 Madrid (28049), Spain
Country: Spain
Phone: 00 34 91196 4718
Fax: 00 34 91196 4420
Line Designation: cbm

Show all 9 genomic features

The vertebrate eye forms through the coordination of two major events: the progressive regionalization of the eye primordium into retina, pigmented epithelium and optic nerve, and the choreographed reorganization of eye cells to give rise to the optic cups. Since 1997 in the Instituto Cajal and from 2011 in the CBMSO, our group has contributed to elucidate the genetic cascade controlling eye specification and differentiation. Our experimental approach is multidisciplinary and involves the use of biochemistry, cell and molecular biology, experimental embryology, transgenesis and gain/loss-of function studies, applied to mouse, chick and teleost fishes. For more information on our current research, see http://web4.cbm.uam.es/joomla-rl/index.php/es/index.php?option=com_content&view=article&id=408

Cardozo, Marcos Post-Doc Di Marco, Francisco Post-Doc DiMeglio, Thomas Post-Doc
Sánchez-Arrones, Luisa Post-Doc Durán-Trío, Lara Graduate Student Hernández-Bejarano, María Graduate Student
Mateo-Ruiz, Inés Graduate Student Moreno-Mármol, Tania Graduate Student Nieto-López, Francisco Graduate Student
Ramón Perea, Juan Graduate Student Rueda-Carrasco, Javier Graduate Student Sanz-Rodríguez, Miriam Graduate Student
Tabanera, Noemí Research Staff Bermejo, M. Jesús Technical Staff Sandonís, Africa Technical Staff

Varga, M., Csályi, K., Bertyák, I., Menyhárd, D.K., Poole, R.J., Cerveny, K.L., Kövesdi, D., Barátki, B., Rouse, H., Vad, Z., Hawkins, T.A., Stickney, H.L., Cavodeassi, F., Schwarz, Q., Young, R.M., Wilson, S.W. (2020) Tissue-Specific Requirement for the GINS Complex During Zebrafish Development. Frontiers in cell and developmental biology. 8:373
Oprişoreanu, A.M., Smith, H.L., Arya, S., Webster, R., Zhong, Z., Wehner, D., Cardozo, M.J., Becker, T., Talbot, K., Becker, C.G. (2019) Interaction of Axonal Chondrolectin with Collagen XIXa1 Is Necessary for Precise Neuromuscular Junction Formation. Cell Reports. 29:1082-1098.e10
Cavodeassi, F., Wilson, S.W. (2019) Looking to the future of zebrafish as a model to understand the genetic basis of eye disease. Human genetics. 138(8-9):993-1000
Bertolini, J.A., Favaro, R., Zhu, Y., Pagin, M., Ngan, C.Y., Wong, C.H., Tjong, H., Vermunt, M.W., Martynoga, B., Barone, C., Mariani, J., Cardozo, M.J., Tabanera, N., Zambelli, F., Mercurio, S., Ottolenghi, S., Robson, P., Creyghton, M.P., Bovolenta, P., Pavesi, G., Guillemot, F., Nicolis, S.K., Wei, C.L. (2019) Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance. Cell Stem Cell. 24:462-476.e6
Young, R.M., Hawkins, T.A., Cavodeassi, F., Stickney, H.L., Schwarz, Q., Lawrence, L.M., Wierzbicki, C., Cheng, B.Y., Luo, J., Ambrosio, E.M., Klosner, A., Sealy, I.M., Rowell, J., Trivedi, C.A., Bianco, I.H., Allende, M.L., Busch-Nentwich, E.M., Gestri, G., Wilson, S.W. (2019) Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification. eLIFE. 8:
Moreno-Marmol, T., Cavodeassi, F., Bovolenta, P. (2018) Setting Eyes on the Retinal Pigment Epithelium. Frontiers in cell and developmental biology. 6:145
Gómez-Gálvez, P., Vicente-Munuera, P., Tagua, A., Forja, C., Castro, A.M., Letrán, M., Valencia-Expósito, A., Grima, C., Bermúdez-Gallardo, M., Serrano-Pérez-Higueras, Ó., Cavodeassi, F., Sotillos, S., Martín-Bermudo, M.D., Márquez, A., Buceta, J., Escudero, L.M. (2018) Scutoids are a geometrical solution to three-dimensional packing of epithelia. Nature communications. 9:2960
Cavodeassi, F. (2018) Dynamic Tissue Rearrangements during Vertebrate Eye Morphogenesis: Insights from Fish Models. Journal of developmental biology. 6(1)
Cardozo, M.J., Mysiak, K.S., Becker, T., Becker, C.G. (2017) Reduce, Reuse, Recycle - Developmental Signals in Spinal Cord Regeneration. Developmental Biology. 432(1):53-62
Shah, M.H., Tabanera, N., Krishnadas, S.R., Pillai, M.R., Bovolenta, P., Sundaresan, P. (2017) Identification and characterization of variants and a novel 4 bp deletion in the regulatory region of SIX6, a risk factor for primary open-angle glaucoma.. Molecular genetics & genomic medicine. 5:323-335
Albuixech-Crespo, B., López-Blanch, L., Burguera, D., Maeso, I., Sánchez-Arrones, L., Moreno-Bravo, J.A., Somorjai, I., Pascual-Anaya, J., Puelles, E., Bovolenta, P., Garcia-Fernàndez, J., Puelles, L., Irimia, M., Ferran, J.L. (2017) Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology. 15:e2001573
Mandriani, B., Castellana, S., Rinaldi, C., Manzoni, M., Venuto, S., Rodriguez-Aznar, E., Galceran, J., Nieto, M.A., Borsani, G., Monti, E., Mazza, T., Merla, G., Micale, L. (2016) Identification of p53-target genes in Danio rerio. Scientific Reports. 6:32474
Valdivia, L.E., Lamb, D.B., Horner, W., Wierzbicki, C., Tafessu, A., Williams, A.M., Gestri, G., Krasnow, A.M., Vleeshouwer-Neumann, T.S., Givens, M., Young, R.M., Lawrence, L.M., Stickney, H.L., Hawkins, T.A., Schwarz, Q.P., Cavodeassi, F., Wilson, S.W., Cerveny, K.L. (2016) Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish. Development (Cambridge, England). 143(7):1087-98
Hernández-Bejarano, M., Gestri, G., Spawls, L., Nieto-López, F., Picker, A., Tada, M., Brand, M., Bovolenta, P., Wilson, S.W., Cavodeassi, F. (2015) Opposing Shh and Fgf signals initiate nasotemporal patterning of the retina. Development (Cambridge, England). 142(22):3933-42
Gómez-Marín, C., Tena, J.J., Acemel, R.D., López-Mayorga, M., Naranjo, S., de la Calle-Mustienes, E., Maeso, I., Beccari, L., Aneas, I., Vielmas, E., Bovolenta, P., Nobrega, M.A., Carvajal, J., Gómez-Skarmeta, J.L. (2015) Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proceedings of the National Academy of Sciences of the United States of America. 112(24):7542-7
Hüsken, U., Stickney, H.L., Gestri, G., Bianco, I.H., Faro, A., Young, R.M., Roussigne, M., Hawkins, T.A., Beretta, C.A., Brinkmann, I., Paolini, A., Jacinto, R., Albadri, S., Dreosti, E., Tsalavouta, M., Schwarz, Q., Cavodeassi, F., Barth, A.K., Wen, L., Zhang, B., Blader, P., Yaksi, E., Poggi, L., Zigman, M., Lin, S., Wilson, S.W., Carl, M. (2014) Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons. Current biology : CB. 24(19):2217-27
Cavodeassi, F. (2014) Integration of anterior neural plate patterning and morphogenesis by the Wnt signaling pathway. Developmental Neurobiology. 74(8):759-71
Cardozo, M.J., Sánchez-Arrones, L., Sandonis, A., Sánchez-Camacho, C., Gestri, G., Wilson, S.W., Guerrero, I., Bovolenta, P. (2014) Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle. Nature communications. 5:4272
Ivanovitch, K., Cavodeassi, F., and Wilson, S.W. (2013) Precocious acquisition of neuroepithelial character in the eye field underlies the onset of eye morphogenesis. Developmental Cell. 27(3):293-305
Cavodeassi, F., Ivanovitch, K., and Wilson, S.W. (2013) Eph/Ephrin signalling maintains eye field segregation from adjacent neural plate territories during forebrain morphogenesis. Development (Cambridge, England). 140(20):4193-4202
Schmidt, K., Cavodeassi, F., Feng, Y., and Stephens, D.J. (2013) Early stages of retinal development depend on Sec13 function. Biology Open. 2(3):256-266
Cavodeassi, F., Bene, F.D., Fürthauer, M., Grabher, C., Herzog, W., Lehtonen, S., Linker, C., Mercader, N., Mikut, R., Norton, W., Strähle, U., Tiso, N., and Foulkes, N.S. (2013) Report of the Second European Zebrafish Principal Investigator Meeting in Karlsruhe, Germany, March 21-24, 2012. Zebrafish. 10(1):119-23
Cavodeassi, F., and Houart, C. (2012) Brain regionalisation: Of signalling centres and boundaries. Developmental Neurobiology. 72(3):218-233
Valdivia, L.E., Young, R.M., Hawkins, T.A., Stickney, H.L., Cavodeassi, F., Schwarz, Q., Pullin, L.M., Villegas, R., Moro, E., Argenton, F., Allende, M.L., and Wilson, S.W. (2011) Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development. Development (Cambridge, England). 138(18):3931-3941
Cerveny, K.L., Cavodeassi, F., Turner, K.J., de Jong-Curtain, T.A., Heath, J.K., and Wilson, S.W. (2010) The zebrafish flotte lotte mutant reveals that the local retinal environment promotes the differentiation of proliferating precursors emerging from their stem cell niche. Development (Cambridge, England). 137(13):2107-2115
Picker, A., Cavodeassi, F., Machate, A., Bernauer, S., Hans, S., Abe, G., Kawakami, K., Wilson, S.W., and Brand, M. (2009) Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina. PLoS Biology. 7(10):e1000214
Hawkins, T.A., Cavodeassi, F., Erdelyi, F., Szabo, G., and Lele, Z. (2008) The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish. BMC Developmental Biology. 8(1):42
Cavodeassi, F., Carreira-Barbosa, F., Young, R., Concha, M., Allende, M.L., Houart, C., Tada, M., and Wilson, S. (2005) Early Stages of Zebrafish Eye Formation Require the Coordinated Activity of Wnt11, Fz5, and the Wnt/Catenin Pathway. Neuron. 47(1):43-56
Martínez-Morales, J.R., Rodrigo, I., and Bovolenta, P. (2004) Eye development: a view from the retina pigmented epithelium. BioEssays : news and reviews in molecular, cellular and developmental biology. 26(7):766-777