ZFIN Lab: Sarris Lab

ZFIN ID: ZDB-LAB-140702-1

ZFIN ID: ZDB-LAB-140702-1

Sarris Lab

PI/Director:	Sarris, Milka
Contact Person:	Sarris, Milka
Email:	milkasarrislab@gmail.com
URL:
Address:
Country:	United States
Phone:
Fax:
Line Designation:	cu

GENOMIC FEATURES ORIGINATING FROM THIS LAB

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STATEMENT OF RESEARCH INTERESTS

I am interested in how cells of the immune system navigate through tissue
environments in order to find sites of infection or injury. This is
essential for defence against invading microbes, while abnormal cell
migration can also contribute to inflammatory diseases.
Immune cell behaviour has traditionally been interrogated in vitro and
remarkably little is still known about how these cells search tissues and
read guidance cues in situ. For example, it is unclear how different
guidance cues propagate within living tissues, how they might establish
informative concentration gradients and how gradients instruct cell
behaviours. To investigate this at the cell biology level, I use a
combination of live imaging in zebrafish, quantitative analyses of cell
behaviour, genetic and optogenetic tools.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Georgantzoglou, A., Poplimont, H., Walker, H.A., Lämmermann, T., Sarris, M. (2022) A two-step search and run response to gradients shapes leukocyte navigation in vivo. The Journal of cell biology. 221(8)

Georgantzoglou, A., Coombs, C., Poplimont, H., Walker, H.A., Sarris, M. (2020) Live Imaging of Chemokine Receptors in Zebrafish Neutrophils During Wound Responses. Journal of visualized experiments : JoVE. (166)

Poplimont, H., Georgantzoglou, A., Boulch, M., Walker, H.A., Coombs, C., Papaleonidopoulou, F., Sarris, M. (2020) Neutrophil Swarming in Damaged Tissue Is Orchestrated by Connexins and Cooperative Calcium Alarm Signals. Current biology : CB. 30(14):2761-2776.e7

Coombs, C., Georgantzoglou, A., Walker, H.A., Patt, J., Merten, N., Poplimont, H., Busch-Nentwich, E.M., Williams, S., Kotsi, C., Kostenis, E., Sarris, M. (2019) Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish. Nature communications. 10:5166

Torraca, V., Gomes, M.C., Sarris, M., Mostowy, S. (2019) Meeting report: Zebrafish Infection and Immunity 2019. Lab animal. 48:284-287

Sarris, M., Olekhnovitch, R., Bousso, P. (2016) Manipulating leukocyte interactions in vivo through optogenetic chemokine release. Blood. 127:e35-41

Murayama, E., Sarris, M., Redd, M., Le Guyader, D., Vivier, C., Horsley, W., Trede, N., Herbomel, P. (2015) NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation. Nature communications. 6:8375

Deng, Q., Sarris, M., Bennin, D.A., Green, J.M., Herbomel, P., and Huttenlocher, A. (2013) Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish. Journal of Leukocyte Biology. 93(5):761-9

Sarris, M., Masson, J.B., Maurin, D., Van der Aa, L.M., Boudinot, P., Lortat-Jacob, H., and Herbomel, P. (2012) Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients. Current biology : CB. 22(24):2375-2382