ZFIN ID: ZDB-LAB-140103-1
Gorelick Lab
PI/Director: Gorelick, Daniel
Contact Person: Gorelick, Daniel
Email: gorelick@bcm.edu
URL: http://gorelicklab.org
Address: Center for Precision Environmental Health Department of Molecular & Cellular Biology Baylor College of Medicine Alkek N1317.07 | 1 Baylor Plaza BCM229 Houston, 77030-3411
Country: United States
Phone: 713.798.3210
Fax:
Line Designation: bcm


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 9 genomic features


STATEMENT OF RESEARCH INTERESTS
We study how steroid hormones and environmental endocrine disrupting compounds influence development. Current projects are exploring membrane steroid signaling, aryl hydrocarbon receptor signaling and hemato-vascular specification and differentiation.


LAB MEMBERS
Zadmajid, Vahid Post-Doc Edwards, Hailey E. Graduate Student Souder, Jaclyn P. Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Abbott, D.A., Mancini, M.G., Bolt, M.J., Szafran, A.T., Neugebauer, K.A., Stossi, F., Gorelick, D.A., Mancini, M.A. (2023) A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals. Heliyon. 10:e23119e23119
Edwards, H.E., Edgington, M.J., Souder, J.P., Gorelick, D.A. (2023) Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos. Development (Cambridge, England). 150(9)
Gorelick, D.A., Lucia, C., Hao, R., Karim, S., Bondesson, M. (2022) Use of Reporter Genes to Analyze Estrogen Response: The Transgenic Zebrafish Model. Methods in molecular biology (Clifton, N.J.). 2418:173-185
Chaturantabut, S., Shwartz, A., Garnaas, M.K., LaBella, K., Li, C.C., Carroll, K.J., Cutting, C.C., Budrow, N., Palaria, A., Gorelick, D.A., Tremblay, K.D., North, T.E., Goessling, W. (2020) Estrogen acts via estrogen receptor 2b to regulate hepatobiliary fate during vertebrate development. Hepatology (Baltimore, Md.). 72(5):1786-1799
Cabrera, R.M., Souder, J.P., Steele, J.W., Yeo, L., Tukeman, G., Gorelick, D.A., Finnell, R.H. (2019) The antagonism of folate receptor by dolutegravir: developmental toxicity reduction by supplemental folic acid. AIDS (London, England). 33(13):1967-1976
Souder, J.P., Gorelick, D.A. (2019) ahr2, but not ahr1a or ahr1b, is required for craniofacial and fin development and TCDD-dependent cardiotoxicity in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 170(1):25-44
Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
Crowder, C.M., Romano, S.N., Gorelick, D.A. (2018) G protein-coupled estrogen receptor is not required for sex determination or ovary function in zebrafish. Endocrinology. 159(10):3515-3523
Crowder, C.M., Lassiter, C.S., Gorelick, D.A. (2017) Nuclear androgen receptor regulates testes organization and oocyte maturation in zebrafish. Endocrinology. 159(2):980-993
Romano, S.N., Edwards, H.E., Souder, J.P., Ryan, K.J., Cui, X., Gorelick, D.A. (2017) G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish. PLoS Genetics. 13:e1007069
Paige Souder, J., Gorelick, D.A. (2017) Assaying uptake of endocrine disruptor compounds in zebrafish embryos and larvae. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 208:105-113
Paige Souder, J., Gorelick, D.A. (2017) Quantification of estradiol uptake in zebrafish embryos and larvae. Toxicological sciences : an official journal of the Society of Toxicology. 158(2):465-474
Gamse, J.T., Gorelick, D.A. (2016) Mixtures, Metabolites, and Mechanisms: Understanding Toxicology Using Zebrafish. Zebrafish. 13:377-378
Gorelick, D.A., Pinto, C.L., Hao, R., Bondesson, M. (2016) Use of Reporter Genes to Analyze Estrogen Response: The Transgenic Zebrafish Model. Methods in molecular biology (Clifton, N.J.). 1366:315-25
Carroll, K.J., Esain, V., Garnaas, M.K., Cortes, M., Dovey, M.C., Nissim, S., Frechette, G.M., Liu, S.Y., Kwan, W., Cutting, C.C., Harris, J.M., Gorelick, D.A., Halpern, M.E., Lawson, N.D., Goessling, W., North, T.E. (2014) Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental Cell. 29:437-53
Romano, S.N., Gorelick, D.A. (2014) Semi-automated Imaging of Tissue-specific Fluorescence in Zebrafish Embryos. Journal of visualized experiments : JoVE. (87)
Gorelick, D.A., Iwanowicz, L.R., Hung, A.L., Blazer, V.S., and Halpern, M.E. (2014) Transgenic Zebrafish Reveal Tissue-Specific Differences in Estrogen Signaling in Response to Environmental Water Samples. Environmental health perspectives. 122(4):356-62
Hao, R., Bondesson, M., Singh, A.V., Riu, A., McCollum, C.W., Knudsen, T.B., Gorelick, D.A., and Gustafsson, J.Å. (2013) Identification of Estrogen Target Genes during Zebrafish Embryonic Development through Transcriptomic Analysis. PLoS One. 8(11):e79020
Gorelick, D.A., and Halpern, M.E. (2011) Visualization of Estrogen Receptor Transcriptional Activation in Zebrafish. Endocrinology. 152(7):2690-703
Gorelick, D.A., Watson, W., and Halpern, M.E. (2008) Androgen receptor gene expression in the developing and adult zebrafish brain. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(10):2987-2995