ZFIN ID: ZDB-LAB-120810-1
Peri Lab
PI/Director: Peri, Francesca
Contact Person: Peri, Francesca
Email: perilabimls@gmail.com
URL: http://www.imls.uzh.ch/en/research/peri.html
Address: Department of Molecular Life Sciences University of Zurich Winterthurerstrasse 190 CH-8057 Zurich
Country: Switzerland
Phone: +41 44 635 31 90
Line Designation: zh

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A central issue in biology is to understand how cells sense changes in the surrounding environment, integrate multiple signals and execute distinct cellular responses in vivo. We investigate this during the development of the vertebrate brain where a group of resident immune cells, the microglia, are able to identify and remove dying neurons that fail to integrate within functional circuits.
Our work in the optically transparent zebrafish brain has shown that microglia form a network that surveys the brain and responds promptly to stimuli. We investigate group-level properties of this cellular network, its spatial organization, coordination and interactions with the local environment by taking a broad range of advanced fluorescence-based imaging approaches to gain a quantitative mechanistic understanding of how microglia scan their environment.
By combining light-sheet microscopy for whole brain imaging with real-time signalling reporters and optogenetic methods for targeted manipulation we address how microglia identify their targets and the flipside of this, namely, how neurons communicate their status to microglia and how signals are transmitted across the brain to ensure efficient neuronal immune interactions in development and disease.

Villani, Ambra Post-Doc Möller, Katrin Graduate Student Zaręba, Joanna Graduate Student
Henkel, Cornelia Fish Facility Staff Oberholzer, Jacqueline Administrative Staff

Möller, K., Brambach, M., Villani, A., Gallo, E., Gilmour, D., Peri, F. (2022) A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo. eLIFE. 11:
Dilshat, R., Fock, V., Kenny, C., Gerritsen, I., Lasseur, R.M.J., Travnickova, J., Eichhoff, O.M., Cerny, P., Möller, K., Sigurbjörnsdóttir, S., Kirty, K., Einarsdottir, B.Ó., Cheng, P.F., Levesque, M., Cornell, R.A., Patton, E.E., Larue, L., de Tayrac, M., Magnúsdóttir, E., Helga Ögmundsdóttir, M., Steingrimsson, E. (2021) MITF reprograms the extracellular matrix and focal adhesion in melanoma. eLIFE. 10:
de Medeiros, G., Kromm, D., Balazs, B., Norlin, N., Günther, S., Izquierdo, E., Ronchi, P., Komoto, S., Krzic, U., Schwab, Y., Peri, F., de Renzis, S., Leptin, M., Rauzi, M., Hufnagel, L. (2020) Cell and tissue manipulation with ultrashort infrared laser pulses in light-sheet microscopy. Scientific Reports. 10:1942
Geirsdottir, L., David, E., Keren-Shaul, H., Weiner, A., Bohlen, S.C., Neuber, J., Balic, A., Giladi, A., Sheban, F., Dutertre, C.A., Pfeifle, C., Peri, F., Raffo-Romero, A., Vizioli, J., Matiasek, K., Scheiwe, C., Meckel, S., Mätz-Rensing, K., van der Meer, F., Thormodsson, F.R., Stadelmann, C., Zilkha, N., Kimchi, T., Ginhoux, F., Ulitsky, I., Erny, D., Amit, I., Prinz, M. (2019) Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program. Cell. 179:1609-1622.e16
Herzog, C., Pons Garcia, L., Keatinge, M., Greenald, D., Moritz, C., Peri, F., Herrgen, L. (2019) Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo. Development (Cambridge, England). 146(9):
Villani, A., Benjaminsen, J., Moritz, C., Henke, K., Hartmann, J., Norlin, N., Richter, K., Schieber, N.L., Franke, T., Schwab, Y., Peri, F. (2019) Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment. Developmental Cell. 49(1):77-88.e7
Casano, A.M., Albert, M., Peri, F. (2016) Developmental Apoptosis Mediates Entry and Positioning of Microglia in the Zebrafish Brain. Cell Reports. 16(4):897-906
Peri, F., Powell, K. (2015) Francesca Peri: Micromanaging the lives of microglia. The Journal of cell biology. 211:208-9
Rossi, F., Casano, A.M., Henke, K., Richter, K., Peri, F. (2015) The SLC7A7 Transporter Identifies Microglial Precursors prior to Entry into the Brain. Cell Reports. 11(7):1008-17
Moritz, C., Berardi, F., Abate, C., Peri, F. (2015) Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries. Neuroscience letters. 591:13-8
Mazaheri, F., Breus, O., Durdu, S., Haas, P., Wittbrodt, J., Gilmour, D., Peri, F. (2014) Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia. Nature communications. 5:4046
Bitomsky, N., Conrad, E., Moritz, C., Polonio-Vallon, T., Sombroek, D., Schultheiss, K., Glas, C., Greiner, V., Herbel, C., Mantovani, F., Del Sal, G., Peri, F., and Hofmann, T.G. (2013) Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. Proceedings of the National Academy of Sciences of the United States of America. 110(45):E4203-4212
Sieger, D., and Peri, F. (2013) Animal models for studying microglia: the first, the popular, and the new.. Glia. 61(1):3-9
Sieger, D., Moritz, C., Ziegenhals, T., Prykhozhij, S., and Peri, F. (2012) Long-Range Ca(2+) Waves Transmit Brain-Damage Signals to Microglia. Developmental Cell. 22(6):1138-1148
Fantin, A., Vieira, J.M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson, S.W., and Ruhrberg, C. (2010) Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood. 116(5):829-840
Peri, F., and Nüsslein-Volhard, C. (2008) Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo. Cell. 133(5):916-927