ZFIN ID: ZDB-LAB-120608-4
Liebel-Lab
PI/Director: Liebel, Urban
Co-PI / Senior
Researcher:		 Gehrig, Jochen
Contact Person: Liebel, Urban
Email: u.liebel@acquifer.de
URL: http://www.acquifer.de
Address: ACQUIFER AG Hermann-von-Helmholtz Platz 1, Building: 717 76344 Eggenstein-Leopoldshafen Germany
Country: Germany
Phone: 0049-7218308740
Fax: 0049-72183087499
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Next Generation High Content Screening platforms.
High Content screening Microscopes. Image processing hardware & software.

Novel (zebrafish) screening microscopy methods, in vivo, 5D,fast image-processing, data analysis.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Westhoff, J.H., Steenbergen, P.J., Thomas, L.S.V., Heigwer, J., Bruckner, T., Cooper, L., Tönshoff, B., Hoffmann, G.F., Gehrig, J. (2020) In vivo High-Content Screening in Zebrafish for Developmental Nephrotoxicity of Approved Drugs. Frontiers in cell and developmental biology. 8:583
Steenbergen, P.J., Heigwer, J., Pandey, G., Tönshoff, B., Gehrig, J., Westhoff, J.H. (2020) A Multiparametric Assay Platform for Simultaneous In Vivo Assessment of Pronephric Morphology, Renal Function and Heart Rate in Larval Zebrafish. Cells. 9(5):
Gierten, J., Pylatiuk, C., Hammouda, O.T., Schock, C., Stegmaier, J., Wittbrodt, J., Gehrig, J., Loosli, F. (2020) Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions. Scientific Reports. 10:2046
Thomas, L.S.V., Gehrig, J. (2020) Multi-template matching: a versatile tool for object-localization in microscopy images. BMC Bioinformatics. 21:44
Pandey, G., Westhoff, J.H., Schaefer, F., Gehrig, J. (2019) A Smart Imaging Workflow for Organ-Specific Screening in a Cystic Kidney Zebrafish Disease Model. International Journal of Molecular Sciences. 20(6)
Gehrig, J., Pandey, G., Westhoff, J.H. (2018) Zebrafish as a Model for Drug Screening in Genetic Kidney Diseases. Frontiers in pediatrics. 6:183
Basu, S., Hadzhiev, Y., Petrosino, G., Nepal, C., Gehrig, J., Armant, O., Ferg, M., Strahle, U., Sanges, R., Müller, F. (2016) The Tetraodon nigroviridis reference transcriptome: developmental transition, length retention and microsynteny of long non-coding RNAs in a compact vertebrate genome. Scientific Reports. 6:33210
Wittmann, C., Reischl, M., Shah, A.H., Kronfuss, E., Mikut, R., Liebel, U., Grabher, C. (2015) A Zebrafish Drug-Repurposing Screen Reveals sGC-Dependent and sGC-Independent Pro-Inflammatory Activities of Nitric Oxide. PLoS One. 10:e0137286
Zaucker, A., Bodur, T., Roest Crollius, H., Hadzhiev, Y., Gehrig, J., Loosli, F., Watson, C., Müller, F. (2014) Description of Embryonic Development of Spotted Green Pufferfish (Tetraodon nigroviridis). Zebrafish. 11(6):509-17
Wittbrodt, J.N., Liebel, U., Gehrig, J. (2014) Generation of orientation tools for automated zebrafish screening assays using desktop 3D printing. BMC Biotechnology. 14:36
Haberle, V., Li, N., Hadzhiev, Y., Plessy, C., Previti, C., Nepal, C., Gehrig, J., Dong, X., Akalin, A., Suzuki, A.M., van IJcken, W.F., Armant, O., Ferg, M., Strähle, U., Carninci, P., Müller, F., and Lenhard, B. (2014) Two independent transcription initiation codes overlap on vertebrate core promoters. Nature. 507(7492):381-385
Westhoff, J.H., Giselbrecht, S., Schmidts, M., Schindler, S., Beales, P.L., Tönshoff, B., Liebel, U., and Gehrig, J. (2013) Development of an Automated Imaging Pipeline for the Analysis of the Zebrafish Larval Kidney. PLoS One. 8(12):e82137
Nepal, C., Hadzhiev, Y., Previty, C., Haberle, V., Li, N., Takahashi, H., Suzuki, A.M., Sheng, Y., Abdelhamid, R., Anand, S., Gehrig, J., Akalin, A., Kockx, C., van der Sloot, A., van Ijcken, W., Armant, O., Rastegar, S., Straehle, U., Stupka, E., Carninci, P., Lenhard, B., and Muller, F. (2013) Dynamic regulation of the transcription initiation landscape at single nucleotide resolution during vertebrate embryogenesis. Genome research. 23(11):1938-50
Wittmann, C., Reischl, M., Shah, A.H., Mikut, R., Liebel, U., and Grabher, C. (2012) Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish. Journal of visualized experiments : JoVE. (65):e4203
Pylatiuk, C., Pfriem, A., Liebel, U., Schulz, S., and Bretthauer, G. (2011) Special Technical Requirements in Automated Handling and Microscopy of Living Organisms. at-Automatisierungstechnik. 59(11):692-698
Peravali, R., Gehrig, J., Giselbrecht, S., Lutjohann, D.S., Hadzhiev, Y., Muller, F., and Liebel, U. (2011) Automated feature detection and imaging for high-resolution screening of zebrafish embryos. Biotechniques. 50(5):319-324
Graf, S.F., Hötzel, S., Liebel, U., Stemmer, A., and Knapp, H.F. (2011) Image-based fluidic sorting system for automated zebrafish egg sorting into multiwell plates. Journal of Laboratory Automation. 16(2):105-111
Alshut, R., Legradi, J., Liebel, U., Yang, L., van Wezel, J., Strähle, U., Mikut, R., and Reischl, M. (2010) Methods for Automated High-Throughput Toxicity Testing Using Zebrafish Embryos. KI 2010: Advances in Artificial Intelligence. 6359:219-226
Gehrig, J. (2010) Function of core promoters in differential gene regulation during embryogenesis. Ph.D. Thesis.
Gehrig, J., Reischl, M., Kalmar, E., Ferg, M., Hadzhiev, Y., Zaucker, A., Song, C., Schindler, S., Liebel, U., and Muller, F. (2009) Automated high-throughput mapping of promoter-enhancer interactions in zebrafish embryos. Nature Methods. 6(12):911-916
Yang, L., Ho, N.Y., Alshut, R., Legradi, J., Weiss, C., Reischl, M., Mikut, R., Liebel, U., Müller, F., and Strähle, U. (2009) Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reproductive toxicology (Elmsford, N.Y.). 28(2):245-253
Ferg, M., Sanges, R., Gehrig, J., Kiss, J., Bauer, M., Lovas, A., Szabo, M., Yang, L., Straehle, U., Pankratz, M.J., Olasz, F., Stupka, E., and Müller, F. (2007) The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. The EMBO journal. 26(17):3945-3956
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