ZFIN ID: ZDB-LAB-120426-1
Rihel Lab
PI/Director: Rihel, Jason
Contact Person: Rihel, Jason
Email: rihel@post.harvard.edu
URL: http://www.homepages.ucl.ac.uk/~ucbtjr3/index.html
Address: 1st Floor Department of Cell and Developmental Biology UCL Gower St. London WC1E 6BT, UK
Country: United Kingdom
Line Designation: u

Show all 6 genomic features

We study the genes and neurons that regulate sleep in zebrafish

Ozcan, Guliz Post-Doc Reichert, Sabine Post-Doc Barlow, Ida Graduate Student
Ghosh, Marcus Graduate Student Shibata, Shannon Graduate Student

Kroll, F., Powell, G.T., Ghosh, M., Gestri, G., Antinucci, P., Hearn, T.J., Tunbak, H., Lim, S., Dennis, H.W., Fernandez, J.M., Whitmore, D., Dreosti, E., Wilson, S.W., Hoffman, E.J., Rihel, J. (2021) A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. eLIFE. 10:
Bryant, D., Seda, M., Peskett, E., Maurer, C., Pomeranz, G., Ghosh, M., Hawkins, T.A., Cleak, J., Datta, S., Hariri, H., Eckert, K.M., Jafree, D.J., Walsh, C., Demetriou, C., Ishida, M., Alemán-Charlet, C., Vestito, L., Seselgyte, R., McDonald, J.G., Bitner-Glindzicz, M., Hemberger, M., Rihel, J., Teboul, L., Henne, W.M., Jenkins, D., Moore, G.E., Stanier, P. (2020) Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations. Scientific Reports. 10:13763
Özcan, G.G., Lim, S., Leighton, P., Allison, W.T., Rihel, J. (2020) Sleep is bi-directionally modified by amyloid beta oligomers. eLIFE. 9:
Ghosh, M., Rihel, J. (2020) Hierarchical Compression Reveals Sub-Second to Day-Long Structure in Larval Zebrafish Behavior. eNeuro. 7(4):
Shibata-Germanos, S., Goodman, J.R., Grieg, A., Trivedi, C.A., Benson, B.C., Foti, S.C., Faro, A., Castellan, R.F.P., Correra, R.M., Barber, M., Ruhrberg, C., Weller, R.O., Lashley, T., Iliff, J.J., Hawkins, T.A., Rihel, J. (2019) Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges. Acta Neuropathologica. 139(2):383-401
Reichert, S., Pavón Arocas, O., Rihel, J. (2019) The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity. Neuron. 104(2):370-384.e5
Ashlin, T.G., Blunsom, N.J., Ghosh, M., Cockcroft, S., Rihel, J. (2018) Pitpnc1a Regulates Zebrafish Sleep and Wake Behavior through Modulation of Insulin-like Growth Factor Signaling. Cell Reports. 24:1389-1396
Rihel, J. (2018) Copper on the brain. Nature Chemical Biology. 14:638-639
Singh, C., Rihel, J., Prober, D.A. (2017) Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling. Current biology : CB. 27(24):3796-3811.e5
Shams, S., Rihel, J., Ortiz, J.G., Gerlai, R. (2017) The zebrafish as a promising tool for modeling human brain disorders: A review based upon an IBNS Symposium. Neuroscience and biobehavioral reviews. 85:176-190
Chen, S., Reichert, S., Singh, C., Oikonomou, G., Rihel, J., Prober, D.A. (2017) Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish. Neuron. 95(1):153-168.e6
Barlow, I.L., Rihel, J. (2017) Zebrafish sleep: from geneZZZ to neuronZZZ. Current opinion in neurobiology. 44:65-71
van Lessen, M., Shibata-Germanos, S., van Impel, A., Hawkins, T.A., Rihel, J., Schulte-Merker, S. (2017) Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development. eLIFE. 6
Naumann, E.A., Fitzgerald, J.E., Dunn, T.W., Rihel, J., Sompolinsky, H., Engert, F. (2016) From Whole-Brain Data to Functional Circuit Models: The Zebrafish Optomotor Response. Cell. 167:947-960.e20
Tuschl, K., Meyer, E., Valdivia, L.E., Zhao, N., Dadswell, C., Abdul-Sada, A., Hung, C.Y., Simpson, M.A., Chong, W.K., Jacques, T.S., Woltjer, R.L., Eaton, S., Gregory, A., Sanford, L., Kara, E., Houlden, H., Cuno, S.M., Prokisch, H., Valletta, L., Tiranti, V., Younis, R., Maher, E.R., Spencer, J., Straatman-Iwanowska, A., Gissen, P., Selim, L.A., Pintos-Morell, G., Coroleu-Lletget, W., Mohammad, S.S., Yoganathan, S., Dale, R.C., Thomas, M., Rihel, J., Bodamer, O.A., Enns, C.A., Hayflick, S.J., Clayton, P.T., Mills, P.B., Kurian, M.A., Wilson, S.W. (2016) Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism-dystonia. Nature communications. 7:11601
Chiu, C.N., Rihel, J., Lee, D.A., Singh, C., Mosser, E.A., Chen, S., Sapin, V., Pham, U., Engle, J., Niles, B.J., Montz, C.J., Chakravarthy, S., Zimmerman, S., Salehi-Ashtiani, K., Vidal, M., Schier, A.F., Prober, D.A. (2016) A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States. Neuron. 89:842-856
Hoffman, E.J., Turner, K.J., Fernandez, J.M., Cifuentes, D., Ghosh, M., Ijaz, S., Jain, R.A., Kubo, F., Bill, B.R., Baier, H., Granato, M., Barresi, M.J., Wilson, S.W., Rihel, J., State, M.W., Giraldez, A.J. (2016) Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 89(4):725-33
Davies, W.I., Tamai, T.K., Zheng, L., Fu, J.K., Rihel, J., Foster, R.G., Whitmore, D., Hankins, M.W. (2015) An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Genome research. 25(11):1666-79
Reichert, S., Randall, R.A., and Hill C.S. (2013) A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border. Development (Cambridge, England). 140(21):4435-4444
Rihel, J., and Schier, A.F. (2013) Sites of action of sleep and wake drugs: insights from model organisms. Current opinion in neurobiology. 23(5):831-40
Sanvitale, C.E., Kerr, G., Chaikuad, A., Ramel, M.C., Mohedas, A.H., Reichert, S., Wang, Y., Triffitt, J.T., Cuny, G.D., Yu, P.B., Hill, C.S., and Bullock, A.N. (2013) A New Class of Small Molecule Inhibitor of BMP Signaling. PLoS One. 8(4):e62721
Rihel, J., and Schier, A.F. (2012) Behavioral screening for neuroactive drugs in zebrafish. Developmental Neurobiology. 72(3):373-385
Emran, F., Rihel, J., Adolph, A.R., and Dowling, J.E. (2010) Zebrafish larvae lose vision at night. Proceedings of the National Academy of Sciences of the United States of America. 107(13):6034-6039
Rihel, J., Prober, D.A., Arvanites, A., Lam, K., Zimmerman, S., Jang, S., Haggarty, S.J., Kokel, D., Rubin, L.L., Peterson, R.T., and Schier, A.F. (2010) Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (New York, N.Y.). 327(5963):348-351
Rihel, J., Prober, D.A., and Schier, A.F. (2010) Chapter 11 - Monitoring sleep and arousal in zebrafish. Methods in cell biology. 100:281-294
Emran, F., Rihel, J., and Dowling, J.E. (2008) A behavioral assay to measure responsiveness of zebrafish to changes in light intensities. Journal of visualized experiments : JoVE. (20)
Prober, D.A., Zimmerman, S., Myers, B.R., McDermott, B.M. Jr, Kim, S.H., Caron, S., Rihel, J., Solnica-Krezel, L., Julius, D., Hudspeth, A.J., and Schier, A.F. (2008) Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(40):10102-10110
Emran, F., Rihel, J., Adolph, A.R., Wong, K.Y., Kraves, S., and Dowling, J.E. (2007) OFF ganglion cells cannot drive the optokinetic reflex in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(48):19126-19131
Prober, D.A., Rihel, J., Onah, A.A., Sung, R.J., and Schier, A.F. (2006) Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(51):13400-13410
Giraldez, A.J., Mishima, Y., Rihel, J., Grocock, R.J., Van Dongen, S., Inoue, K., Enright, A.J., and Schier, A.F. (2006) Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs. Science (New York, N.Y.). 312(5770):75-79