ZFIN Lab: Mostowy Lab

ZFIN ID: ZDB-LAB-120302-1

Mostowy Lab

PI/Director:	Mostowy, Serge
Contact Person:	Mostowy, Serge
Email:	s.mostowy@imperial.ac.uk
URL:	http://www1.imperial.ac.uk/departmentofmedicine/divisions/infectiousdiseases/microbiology/hostdefence/
Address:	Level 2 Flowers Building South Kensington Imperial College London SW7 2AZ UK
Country:	United Kingdom
Phone:	+44 (0)20 7594 3072
Fax:	+44 (0)20 7594 3095
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

The cell biology of zebrafish infection.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Torraca, V., White, R.J., Sealy, I.M., Mazon-Moya, M., Duggan, G., Willis, A., Busch-Nentwich, E.M., Mostowy, S. (2023) Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri. Disease models & mechanisms. 17(1):

Gomes, M.C., Brokatzky, D., Bielecka, M.K., Wardle, F.C., Mostowy, S. (2023) Shigella induces epigenetic reprogramming of zebrafish neutrophils. Science advances. 9:eadf9706eadf9706

Torraca, V., Brokatzky, D., Miles, S.L., Chong, C.E., De Silva, P.M., Baker, S., Jenkins, C., Holt, K.E., Baker, K.S., Mostowy, S. (2023) Shigella serotypes associated with carriage in humans establish persistent infection in zebrafish. The Journal of infectious diseases. 228(8):1108-1118

Lensen, A., Gomes, M.C., López-Jiménez, A.T., Mostowy, S. (2023) An automated microscopy workflow to study Shigella-neutrophil interactions and antibiotic efficacy in vivo. Disease models & mechanisms. 16(6):

Miles, S.L., Torraca, V., Dyson, Z.A., López-Jiménez, A.T., Foster-Nyarko, E., Lobato-Márquez, D., Jenkins, C., Holt, K.E., Mostowy, S. (2023) Acquisition of a large virulence plasmid (pINV) promoted temperature-dependent virulence and global dispersal of O96:H19 enteroinvasive Escherichia coli. mBio. 14(4):e0088223

Torraca, V., Bielecka, M.K., Gomes, M.C., Brokatzky, D., Busch-Nentwich, E.M., Mostowy, S. (2023) Zebrafish null mutants of Sept6 and Sept15 are viable but susceptible to Shigella infection. Cytoskeleton (Hoboken, N.J.). 80(7-8):266-274

Huan, Y.W., Torraca, V., Brown, R., Fa-Arun, J., Miles, S.L., Oyarzún, D.A., Mostowy, S., Wang, B. (2023) P1 Bacteriophage-Enabled Delivery of CRISPR-Cas9 Antimicrobial Activity Against Shigella flexneri. ACS synthetic biology. 12(3):709-721

Yakimovich, A., Huttunen, M., Samolej, J., Clough, B., Yoshida, N., Mostowy, S., Frickel, E.M., Mercer, J. (2020) Mimicry Embedding Facilitates Advanced Neural Network Training for Image-Based Pathogen Detection. mSphere. 5(5):

Ulhuq, F.R., Gomes, M.C., Duggan, G.M., Guo, M., Mendonca, C., Buchanan, G., Chalmers, J.D., Cao, Z., Kneuper, H., Murdoch, S., Thomson, S., Strahl, H., Trost, M., Mostowy, S., Palmer, T. (2020) A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition. Proceedings of the National Academy of Sciences of the United States of America. 117(34):20836-20847

Yoshida, N., Domart, M.C., Peddie, C.J., Yakimovich, A., Mazon-Moya, M.J., Hawkins, T.A., Collinson, L., Mercer, J., Frickel, E.M., Mostowy, S. (2020) The zebrafish as a novel model for the in vivo study of Toxoplasma gondii replication and interaction with macrophages. Disease models & mechanisms. 13(7):

Torraca, V., Kaforou, M., Watson, J., Duggan, G.M., Guerrero-Gutierrez, H., Krokowski, S., Hollinshead, M., Clarke, T.B., Mostowy, R.J., Tomlinson, G.S., Sancho-Shimizu, V., Clements, A., Mostowy, S. (2019) Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence. PLoS pathogens. 15:e1008006

Gomes, M.C., Mostowy, S. (2019) The Case for Modeling Human Infection in Zebrafish. Trends in microbiology. 28(1):10-18

Torraca, V., Gomes, M.C., Sarris, M., Mostowy, S. (2019) Meeting report: Zebrafish Infection and Immunity 2019. Lab animal. 48:284-287

Mickiewicz, K.M., Kawai, Y., Drage, L., Gomes, M.C., Davison, F., Pickard, R., Hall, J., Mostowy, S., Aldridge, P.D., Errington, J. (2019) Possible role of L-form switching in recurrent urinary tract infection. Nature communications. 10:4379

Price, R.L., Bugeon, L., Mostowy, S., Makendi, C., Wren, B.W., Williams, H.D., Willcocks, S.J. (2019) In vitro and in vivo properties of the bovine antimicrobial peptide, Bactenecin 5. PLoS One. 14:e0210508

Mostowy, S., Ewers, H. (2019) Editorial overview: The molecular and cellular biology of septins. Cytoskeleton (Hoboken, N.J.). 76:5-6

Willis, A.R., Torraca, V., Gomes, M.C., Shelley, J., Mazon-Moya, M., Filloux, A., Lo Celso, C., Mostowy, S. (2018) Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection.. mBio. 9(3)

Inglesfield, S., Jasiulewicz, A., Hopwood, M., Tyrrell, J., Youlden, G., Mazon-Moya, M., Millington, O.R., Mostowy, S., Jabbari, S., Voelz, K. (2018) Robust Phagocyte Recruitment Controls the Opportunistic Fungal Pathogen Mucor circinelloides in Innate Granulomas In Vivo.. mBio. 9(2)

Duggan, G.M., Mostowy, S. (2018) Use of zebrafish to study Shigella infection.. Disease models & mechanisms. 11(2)

Yoshida, N., Frickel, E.M., Mostowy, S. (2017) Macrophage-Microbe Interactions: Lessons from the Zebrafish Model. Frontiers in immunology. 8:1703

Torraca, V., Mostowy, S. (2017) Zebrafish Infection: From Pathogenesis to Cell Biology. Trends in cell biology. 28(2):143-156

Mazon-Moya, M.J., Willis, A.R., Torraca, V., Boucontet, L., Shenoy, A.R., Colucci-Guyon, E., Mostowy, S. (2017) Septins restrict inflammation and protect zebrafish larvae from Shigella infection. PLoS pathogens. 13:e1006467

Liew, N., Mazon Moya, M.J., Wierzbicki, C.J., Hollinshead, M., Dillon, M.J., Thornton, C.R., Ellison, A., Cable, J., Fisher, M.C., Mostowy, S. (2017) Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts. Nature communications. 8:15048

McCarthy, R.R., Mazon-Moya, M.J., Moscoso, J.A., Hao, Y., Lam, J.S., Bordi, C., Mostowy, S., Filloux, A. (2017) Cyclic-di-GMP regulates lipopolysaccharide modification and contributes to Pseudomonas aeruginosa immune evasion. Nature microbiology. 2:17027

Mesquita, F.S., Brito, C., Mazon Moya, M.J., Pinheiro, J.C., Mostowy, S., Cabanes, D., Sousa, S. (2017) Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins. EMBO reports. 18:303-318

Willis, A.R., Moore, C., Mazon-Moya, M., Krokowski, S., Lambert, C., Till, R., Mostowy, S., Sockett, R.E. (2016) Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae. Current biology : CB. 26(24):3343-3351

Shah, A., Kannambath, S., Herbst, S., Rogers, A., Soresi, S., Carby, M., Reed, A., Mostowy, S., Fisher, M.C., Shaunak, S., Armstrong-James, D.P. (2016) Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus During Macrophage Cell Death. American Journal of Respiratory and Critical Care Medicine. 194(9):1127-1139

Willis, A., Mazon-Moya, M., Mostowy, S. (2016) Investigation of septin biology in vivo using zebrafish. Methods in cell biology. 136:221-41

Herbst, S., Shah, A., Mazon Moya, M., Marzola, V., Jensen, B., Reed, A., Birrell, M.A., Saijo, S., Mostowy, S., Shaunak, S., Armstrong-James, D. (2015) Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus. EMBO Molecular Medicine. 7(3):240-58

Mazon Moya, M.J., Colucci-Guyon, E., Mostowy, S. (2014) Use of Shigella flexneri to Study Autophagy-Cytoskeleton Interactions. Journal of visualized experiments : JoVE. (91):e51601

Mostowy, S., Boucontet, L., Mazon Moya, M.J., Sirianni, A., Boudinot, P., Hollinshead, M., Cossart, P., Herbomel, P., Levraud, J.P., and Colucci-Guyon, E. (2013) The Zebrafish as a New Model for the In Vivo Study of Shigella flexneri Interaction with Phagocytes and Bacterial Autophagy. PLoS pathogens. 9(9):e1003588