ZFIN Lab: Lopes Lab

ZFIN ID: ZDB-LAB-120124-5

Lopes Lab

PI/Director:	Lopes, Susana
Contact Person:
Email:	susana.lopes@fcm.unl.pt
URL:	http://cedoc.unl.pt
Address:	Cilia Regulation and Disease Lab CEDOC - Centro de Estudos de Doenças Crónicas Faculdade de Ciências Médicas Universidade Nova de Lisboa Campo Mártires da Pátria, 130 1169-056 Lisboa Portugal
Country:	Portugal
Phone:	(+351) 21 115 7706
Fax:	(+351) 21 885 1920
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our lab aims to investigate the regulation of cilia length and motility.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Sampaio, P., Pestana, S., Bota, C., Guerrero, A., Telley, I.A., Smith, D., Lopes, S.S. (2023) Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking. eLIFE. 12:

Bota, C., Martins, G.G., Lopes, S.S. (2023) Dand5 is involved in zebrafish tailbud cell movement. Frontiers in cell and developmental biology. 10:989615989615

Oliveira, I., Jacinto, R., Pestana, S., Nolasco, F., Calado, J., Lopes, S.S., Roxo-Rosa, M. (2021) Zebrafish Model as a Screen to Prevent Cyst Inflation in Autosomal Dominant Polycystic Kidney Disease. International Journal of Molecular Sciences. 22(16):

Pinto, A.L., Rasteiro, M., Bota, C., Pestana, S., Sampaio, P., Hogg, C., Burgoyne, T., Lopes, S.S. (2021) Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia. International Journal of Molecular Sciences. 22(16):

Jacinto, R., Sampaio, P., Roxo-Rosa, M., Pestana, S., Lopes, S.S. (2021) Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5. Frontiers in cell and developmental biology. 9:624531

Kuhns, S., Seixas, C., Pestana, S., Tavares, B., Nogueira, R., Jacinto, R., Ramalho, J.S., Simpson, J.C., Andersen, J.S., Echard, A., Lopes, S.S., Barral, D.C., Blacque, O.E. (2019) Rab35 controls cilium length, function and membrane composition. EMBO reports. 20(10):e47625

Burkhalter, M.D., Sridhar, A., Sampaio, P., Jacinto, R., Burczyk, M.S., Donow, C., Angenendt, M., Investigators, C.N.F.C.H.D., Hempel, M., Walther, P., Pennekamp, P., Omran, H., Lopes, S.S., Ware, S.M., Philipp, M. (2019) Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. The Journal of Clinical Investigation. 130:2841-2855

Morello, J., Derks, R.J.E., Lopes, S.S., Steenvoorden, E., Monteiro, E.C., Mayboroda, O.A., Pereira, S.A. (2018) Zebrafish Larvae Are a Suitable Model to Investigate the Metabolic Phenotype of Drug-Induced Renal Tubular Injury. Frontiers in pharmacology. 9:1193

Gorgulho, R., Jacinto, R., Lopes, S.S., Pereira, S.A., Tranfield, E.M., Martins, G.G., Gualda, E.J., Derks, R.J.E., Correia, A.C., Steenvoorden, E., Pintado, P., Mayboroda, O.A., Monteiro, E.C., Morello, J. (2017) Usefulness of zebrafish larvae to evaluate drug-induced functional and morphological renal tubular alterations. Archives of toxicology. 92(1):411-423

Tavares, B., Jacinto, R., Sampaio, P., Pestana, S., Pinto, A., Vaz, A., Roxo-Rosa, M., Gardner, R., Lopes, T., Schilling, B., Henry, I., Saúde, L., Lopes, S.S. (2017) Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer.. eLIFE. 6

Pintado, P., Sampaio, P., Tavares, B., Montenegro-Johnson, T.D., Smith, D.J., Lopes, S.S. (2017) Dynamics of cilia length in left-right development. Royal Society open science. 4:161102

Lopes, S.S., Distel, M., Linker, C., Fior, R., Monteiro, R., Bianco, I.H., Portugues, R., Strähle, U., Saúde, L. (2016) Report of the 4th European Zebrafish Principal Investigator Meeting. Zebrafish. 13(6):590-595

Montenegro-Johnson, T.D., Baker, D.I., Smith, D.J., Lopes, S.S. (2016) Three-dimensional flow in Kupffer's Vesicle. Journal of mathematical biology. 73(3):705-25

Roxo-Rosa, M., Jacinto, R., Sampaio, P., Lopes, S.S. (2015) The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR. Biology Open. 4(11):1356-66

Lu, Q., Insinna, C., Ott, C., Stauffer, J., Pintado, P.A., Rahajeng, J., Baxa, U., Walia, V., Cuenca, A., Hwang, Y.S., Daar, I.O., Lopes, S., Lippincott-Schwartz, J., Jackson, P.K., Caplan, S., Westlake, C.J. (2015) Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation. Nature cell biology. 17:228-40

Sampaio, P., Ferreira, R.R., Guerrero, A., Pintado, P., Tavares, B., Amaro, J., Smith, A.A., Montenegro-Johnson, T., Smith, D.J., Lopes, S.S. (2014) Left-Right Organizer Flow Dynamics: How Much Cilia Activity Reliably Yields Laterality?. Developmental Cell. 29(6):716-28

Casalou, C., Seixas, C., Portelinha, A., Pintado, P., Barros, M., Ramalho, J.S., Lopes, S.S., Barral, D.C. (2014) Arl13b and the non-muscle myosin heavy chain IIA are required for circular dorsal ruffle formation and cell migration. Journal of Cell Science. 127(Pt 12):2709-22

Lourenço, R., Lopes, S.S., and Saude, L. (2010) Left-Right Function of dmrt2 Genes Is Not Conserved between Zebrafish and Mouse. PLoS One. 5(12):e14438

Lopes, S.S., Lourenço, R., Pacheco, L., Moreno, N., Kreiling, J., and Saude, L. (2010) Notch signalling regulates left-right asymmetry through ciliary length control. Development (Cambridge, England). 137(21):3625-3632

Lopes, S.S., Yang, X., Müller, J., Carney, T.J., McAdow, A.R., Rauch, G.J., Jacoby, A.S., Hurst, L.D., Delfino-Machín, M., Haffter, P., Geisler, R., Johnson, S.L., Ward, A., and Kelsh, R.N. (2008) Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genetics. 4(3):e1000026

Lopes, S.S., Rauch, G.-J., Geisler, R., Haffter, P., and Kelsh, R.N. (2002) Molecular characterization of the zebrafish pigment gene, shady. Pigment cell research. 15(9):75

Dutton, K.A., Pauliny, A., Lopes, S.S., Elworthy, S., Carney, T.J., Rauch, J., Geisler, R., Haffter, P., and Kelsh, R.N. (2001) Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates. Development (Cambridge, England). 128(21):4113-4125

Parichy, D.M., Mellgren, E.M., Rawls, J.F., Lopes, S.S., Kelsh, R.N., and Johnson, S.L. (2000) Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. Developmental Biology. 227(2):294-306