Lab

Monk Lab

Lab ID
ZDB-LAB-110912-3
PI / Directory
Monk, Kelly
Contact Person
Monk, Kelly
Email
monk@ohsu.edu
URL
https://www.ohsu.edu/xd/research/centers-institutes/vollum/faculty/monklab.cfm
Address
Kelly Monk Lab Vollum Institute, L474 Oregon Health & Science University 3181 S.W. Sam Jackson Pk. Rd. Portland, Oregon 97239
Country
United States
Phone
503-494-2980
Fax
Line Designation
vo
Genomic Features
Statement of Research Interest
The myelin sheath surrounding axons is an exquisite example of a specialized cell-cell interaction in the vertebrate nervous system. Myelin is formed by glial cells called oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. These cells associate with axons, and elaborate massive amounts of cytoplasm, ultimately wrapping axons to form the myelin sheath. While much progress has been made to determine how glial cells make myelin, there is still much we do not understand. How do glial cells transition from simple axonal ensheathment to membrane spiraling? What are the signals between glial cells and axons that regulate myelination? How is myelin maintained once it is formed? When myelin regenerates in disease or after injury, do the same developmental pathways that regulate myelination regulate remyelination? We use mouse and zebrafish models to better understand how myelinated axons are formed, maintained, and regenerated.
Lab Members
Zebrafish Publications of lab members