ZFIN ID: ZDB-LAB-110411-1
Feijoo Lab
PI/Director: Feijoo, Carmen G.
Contact Person: Feijoo, Carmen G.
Email: cfeijoo@unab.cl
Address: Departamento de Ciencias Biologicas Facultad de Ciencias de la Vida Universidad Andres Bello Republica 330, Santiago
Country: Chile
Phone: 56-2-7703225
Line Designation: None assigned


We are interested in understanding the cellular and molecular mechanism that control mucosal tolerance and inflammation in the intestine of zebrafish, as well as the influence of the microbiota in both processes. To this end, we are characterizing the specific participation of different immune cells, with emphasis on macrophage, dendritic cells, and T cells. In addition, we are Iooking to identify the neutrophils subpopulation that participate in a chronic intestinal inflammatory process, and at the same time we are searching for natural compounds that protect the intestine from tissue damage caused by the excessive neutrophils infiltration into the intestine during chronic inflammation. Finally, we are exploring different nanoparticles platforms to improve the effect of anti-inflammatory drugs.

Caruffo, Mario Post-Doc Del Rio, Yalen Graduate Student Lazcano, Fernando Fish Facility Staff
Solis, Camila Administrative Staff Astorga, Katterine

Solis, C.J., Hamilton, M.K., Caruffo, M., Garcia-Lopez, J.P., Navarrete, P., Guillemin, K., Feijoo, C.G. (2020) Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Frontiers in immunology. 11:1330
Avendaño-Herrera, R., Benavides, I., Espina, J.A., Soto-Comte, D., Poblete-Morales, M., Valdés, J.A., Feijóo, C.G., Reyes, A.E. (2020) Zebrafish (Danio rerio) as an animal model for bath infection by Flavobacterium psychrophilum. Journal of fish diseases. 43(5):561-570
Fehrmann-Cartes, K., Coronado, M., Hernández, A.J., Allende, M.L., Feijoo, C.G. (2019) Anti-inflammatory effects of aloe vera on soy meal-induced intestinal inflammation in zebrafish. Fish & shellfish immunology. 95:564-573
García-López, J.P., Vilos, C., Feijóo, C.G. (2019) Zebrafish, a model to develop nanotherapeutics that control neutrophils response during inflammation. Journal of controlled release : official journal of the Controlled Release Society. 313:14-23
Coronado, M., Solis, C.J., Hernandez, P.P., Feijóo, C.G. (2019) Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile. Frontiers in immunology. 10:610
Valenzuela, M.J., Caruffo, M., Herrera, Y., Medina, D.A., Coronado, M., Feijóo, C.G., Muñoz, S., Garrido, D., Troncoso, M., Figueroa, G., Toro, M., Reyes-Jara, A., Magne, F., Navarrete, P. (2018) Evaluating the Capacity of Human Gut Microorganisms to Colonize the Zebrafish Larvae (Danio rerio).. Frontiers in microbiology. 9:1032
Bravo-Tello, K., Ehrenfeld, N., Solís, C.J., Ulloa, P.E., Hedrera, M., Pizarro-Guajardo, M., Paredes-Sabja, D., Feijóo, C.G. (2017) Effect of microalgae on intestinal inflammation triggered by soybean meal and bacterial infection in zebrafish. PLoS One. 12:e0187696
Zuñiga-Traslaviña, C., Bravo, K., Reyes, A.E., Feijóo, C.G. (2017) Cxcl8b and Cxcr2 Regulate Neutrophil Migration through Bloodstream in Zebrafish. Journal of immunology research. 2017:6530531
Caruffo, M., Navarrete, N.C., Salgado, O.A., Faúndez, N.B., Gajardo, M.C., Feijóo, C.G., Reyes-Jara, A., García, K., Navarrete, P. (2016) Protective Yeasts Control V. anguillarum Pathogenicity and Modulate the Innate Immune Response of Challenged Zebrafish (Danio rerio) Larvae.. Frontiers in cellular and infection microbiology. 6:127
Ulloa, P.E., Solís, C.J., De la Paz, J.F., Alaurent, T.G., Caruffo, M., Hernández, A.J., Dantagnan, P., Feijóo, C.G. (2016) Lactoferrin Decreases the Intestinal Inflammation Triggered by a Soybean Meal-Based Diet in Zebrafish. Journal of immunology research. 2016:1639720
Caruffo, M., Navarrete, N., Salgado, O., Díaz, A., López, P., García, K., Feijóo, C.G., Navarrete, P. (2015) Potential probiotic yeasts isolated from the fish gut protect zebrafish (Danio rerio) from a Vibrio anguillarum challenge. Frontiers in microbiology. 6:1093
Solís, C.J., Poblete-Morales, M., Cabral, S., Valdés, J.A., Reyes, A.E., Avendaño-Herrera, R., Feijóo, C.G. (2015) Neutrophil Migration in the Activation of the Innate Immune Response to Different Flavobacterium psychrophilum Vaccines in Zebrafish (Danio rerio). Journal of immunology research. 2015:515187
Ulloa, P.E., Medrano, J.F., Feijoo, C.G. (2014) Zebrafish as animal model for aquaculture nutrition research. Frontiers in genetics. 5:313
Galdames, J.A., Zuñiga-Traslaviña, C., Reyes, A.E., Feijóo, C.G. (2014) Gcsf-Chr19 Promotes Neutrophil Migration to Damaged Tissue through Blood Vessels in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 193(1):372-8
Fuentes-Appelgren, P., Opazo, R., Barros, L., Feijoó, C.G., Urzúa, V., and Romero, J. (2014) Effect of the dietary inclusion of soybean components on the innate immune system in zebrafish. Zebrafish. 11(1):41-49
Hedrera, M.I., Galdames, J.A., Jimenez-Reyes, M.F., Reyes, A.E., Avendaño-Herrera, R., Romero, J., and Feijóo, C.G. (2013) Soybean meal induces intestinal inflammation in zebrafish larvae. PLoS One. 8(7):e69983
Espina, J., Feijoo, C.G., Solis, C., and Glavic, A. (2013) csrnp1a Is Necessary for the Development of Primitive Hematopoiesis Progenitors in Zebrafish. PLoS One. 8(1):e53858
Barros-Becker, F., Romero, J., Pulgar, A., and Feijoo, C.G. (2012) Persistent oxytetracycline exposure induces an inflammatory process that improves regenerative capacity in zebrafish larvae. PLoS One. 7(5):e36827
Feijoo, C.G., Oñate, M.G., Milla, L.A., and Palma, V.A. (2011) Sonic hedgehog (Shh)-Gli signaling controls neural progenitor cell division in the developing tectum in zebrafish. The European journal of neuroscience. 33(4):589-598
Pistocchi, A., Feijoo, C.G., Cabrera, P., Villablanca, E.J., Allende, M.L., and Cotelli, F. (2009) The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line. BMC Developmental Biology. 9:58
Feijoo, C.G., Sarrazin, A.F., Allende, M.L., and Glavic, A. (2009) Cystein-serine-rich nuclear protein 1, Axud1/Csrnp1, is essential for cephalic neural progenitor proliferation and survival in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 238(8):2034-2043
Feijoo, C.G., Saldias, M.P., De la Paz, J.F., Gómez-Skarmeta, J.L., and Allende, M.L. (2009) Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. Molecular and cellular neurosciences. 40(3):328-337
Allende, M.L., Manzanares, M., Tena, J.J., Feijoo, C.G., and Gomez-Skarmeta, J.L. (2006) Cracking the genome's second code: Enhancer detection by combined phylogenetic footprinting and transgenic fish and frog embryos. Methods (San Diego, Calif.). 39(3):212-219
de la Calle-Mustienes, E., Feijoo, C.G., Manzanares, M., Tena, J.J., Rodriguez-Seguel, E., Leticia, A., Allende, M.L., and Gomez-Skarmeta, J.L. (2005) A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois cluster gene deserts. Genome research. 15(8):1061-1072
Glavic, A., Maris Honoré, S., Gloria Feijóo, C., Bastidas, F., Allende, M.L., and Mayor, R. (2004) Role of BMP signaling and the homeoprotein iroquois in the specification of the cranial placodal field. Developmental Biology. 272(1):89-103
Feijoo, C.G., Manzanares, M., De La Calle-Mustienes, E., Gómez-Skarmeta, J.L., and Allende, M.L. (2004) The Irx gene family in zebrafish: genomic structure, evolution and initial characterization of irx5b. Development genes and evolution. 214(6):277-284