ZFIN Lab: Wilkinson Lab

ZFIN ID: ZDB-LAB-100915-2

Wilkinson Lab

PI/Director:	Wilkinson, David
Contact Person:	Wilkinson, David
Email:	david.wilkinson@crick.ac.uk
URL:	https://www.crick.ac.uk/david-wilkinson
Address:	The Francis Crick Institute, Mill Hill Laboratory The Ridgeway Mill Hill London, NW7 1AA United Kingdom
Country:	United Kingdom
Phone:	+44 20 8816 2404
Fax:	+44-20 8816 2523
Line Designation:	fci

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 20 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Xu, Qiling Post-Doc

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Leino, S.A., Constable, S.C.J., Streit, A., Wilkinson, D.G. (2023) Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain. Development (Cambridge, England). 150(18):

Hughes, S.M., Escaleira, R.C., Wanders, K., Koth, J., Wilkinson, D.G., Xu, Q. (2022) Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan. Biology Open. 11(8):

McCallum, S., Obata, Y., Fourli, E., Boeing, S., Peddie, C.J., Xu, Q., Horswell, S., Kelsh, R., Collinson, L., Wilkinson, D., Pin, C., Pachnis, V., Heanue, T.A. (2020) Enteric glia as a source of neural progenitors in adult zebrafish. eLIFE. 9:

Tambalo, M., Mitter, R., Wilkinson, D.G. (2020) A single cell transcriptome atlas of the developing zebrafish hindbrain. Development (Cambridge, England). 147(6):

Thestrup, M.I., Caviglia, S., Cayuso, J., Heyne, R.L.S., Ahmad, R., Hofmeister, W., Satriano, L., Wilkinson, D.G., Andersen, J.B., Ober, E.A. (2019) A morphogenetic EphB/EphrinB code controls hepatopancreatic duct formation. Nature communications. 10:5220

Cayuso, J., Xu, Q., Addison, M., Wilkinson, D.G. (2019) Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness. eLIFE. 8:

Addison, M., Xu, Q., Cayuso, J., Wilkinson, D.G. (2018) Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain. Developmental Cell. 45:606-620.e3

Jacob, J., Ribes, V., Moore, S., Constable, S.C., Sasai, N., Gerety, S.S., Martin, D.J., Sergeant, C.P., Wilkinson, D.G., and Briscoe, J. (2014) Valproic Acid silencing of ascl1b/ascl1 results in the failure of serotonergic differentiation in a zebrafish model of Fetal Valproate Syndrome. Disease models & mechanisms. 7(1):107-17

John, J., Ribes, V., Moore, S., Constable, S., Wilkinson, D., Briscoe, J. (2013) A chemical-genetics approach to study the molecular pathology of central serotonin abnormalities in fetal valproate syndrome. Journal of neurology, neurosurgery, and psychiatry. 84(11):e2

Breau, M.A., Wilkinson, D.G., and Xu, Q. (2013) A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. 110(42):16892-16897

Gerety, S.S., Breau, M.A., Sasai, N., Xu, Q., Briscoe, J., and Wilkinson, D.G. (2013) An inducible transgene expression system for zebrafish and chick. Development (Cambridge, England). 140(10):2235-2243

Moore, S., Ribes, V., Terriente, J., Wilkinson, D., Relaix, F., Briscoe, J. (2013) Distinct regulatory mechanisms act to establish and maintain Pax3 expression in the developing neural tube. PLoS Genetics. 9:e1003811

Terriente, J., Gerety, S.S., Watanabe-Asaka, T., Gonzalez-Quevedo, R., and Wilkinson, D.G. (2012) Signalling from hindbrain boundaries regulates neuronal clustering that patterns neurogenesis. Development (Cambridge, England). 139(16):2978-2987

Breau, M.A., Wilson, D., Wilkinson, D.G., and Xu, Q. (2012) Chemokine and Fgf signalling act as opposing guidance cues in formation of the lateral line primordium. Development (Cambridge, England). 139(12):2246-2253

Gerety, S.S., and Wilkinson, D.G. (2011) Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development. Developmental Biology. 350(2):279-289

Feng, Y., and Xu, Q. (2010) Pivotal role of hmx2 and hmx3 in zebrafish inner ear and lateral line development. Developmental Biology. 339(2):507-518

Gonzalez-Quevedo, R., Lee, Y., Poss, K.D., and Wilkinson, D.G. (2010) Neuronal Regulation of the Spatial Patterning of Neurogenesis. Developmental Cell. 18(1):136-147

Sobieszczuk, D.F., Poliakov, A., Xu, Q., and Wilkinson, D.G. (2010) A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation. Genes & Development. 24(2):206-218

Nikolaou, N., Watanabe-Asaka, T., Gerety, S., Distel, M., Köster, R.W., and Wilkinson, D.G. (2009) Lunatic fringe promotes the lateral inhibition of neurogenesis. Development (Cambridge, England). 136(15):2523-2533

Boldajipour, B., Mahabaleshwar, H., Kardash, E., Reichman-Fried, M., Blaser, H., Minina, S., Wilson, D., Xu, Q., and Raz, E. (2008) Control of chemokine-guided cell migration by ligand sequestration. Cell. 132(3):463-473

Holder, N., and Xu, Q. (2008) The zebrafish: an overview of its early development. Methods in molecular biology (Clifton, N.J.). 461:483-491

Xu, Q., Stemple, D., and Joubin, K. (2008) Microinjection and cell transplantation in zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 461:513-520

Amoyel, M., Cheng, Y.C., Jiang, Y.J., and Wilkinson, D.G. (2005) Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain. Development (Cambridge, England). 132(4):775-785

Cheng, Y.C., Amoyel, M., Qiu, X., Jiang, Y.J., Xu, Q., and Wilkinson, D.G. (2004) Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. Developmental Cell. 6(4):539-550

Pasini, A., Jiang, Y.J., and Wilkinson, D.G. (2004) Two zebrafish Notch-dependent hairy/Enhancer-of-split-related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm. Development (Cambridge, England). 131(7):1529-1541

Pasini, A. and Wilkinson, D.G. (2002) Stabilizing the regionalisation of the developing vertebrate central nervous system. BioEssays : news and reviews in molecular, cellular and developmental biology. 24(5):427-438

Pasini, A., Henrique, D., and Wilkinson, D.G. (2001) The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites. Mechanisms of Development. 100(2):317-321

Xu, Q., Mellitzer, G., and Wilkinson, D.G. (2000) Roles of Eph receptors and ephrins in segmental patterning. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 355(1399):993-1002

Manzanares, M., Trainor, P.A., Nonchev, S., Ariza-McNaughton, L., Brodie, J., Gould, A., Marshall, H., Morrison, A., Kwan, C.-T., Sham, M.-H., Wilkinson, D.G., and Krumlauf, R. (1999) The role of kreisler in segmentation during hindbrain development. Developmental Biology. 211(2):220-237

Mellitzer, G., Xu, Q., and Wilkinson, D.G. (1999) Eph receptors and ephrins restrict cell intermingling and communication. Nature. 400(6739):77-81

Xu, Q., Mellitzer, G., Robinson, V., and Wilkinson, D.G. (1999) In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature. 399(6733):267-271

Holder, N. and Xu, Q. (1999) Microinjection of DNA, RNA, and protein into the fertilized zebrafish egg for analysis of gene function. Methods in molecular biology (Clifton, N.J.). 97:487-490

Holder, N. and Xu, Q. (1999) The zebrafish. An overview of its early development. Methods in molecular biology (Clifton, N.J.). 97:431-439

Xu, Q. (1999) Microinjection into zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 127:125-132

Cooke, J.E., Xu, Q.L., Wilson, S.W., and Holder, N. (1997) Characterisation of five novel zebrafish Eph-related receptor tyrosine kinases suggests roles in patterning the neural plate. Development genes and evolution. 206:515-531

Lee, K.H., Xu, Q., and Breitbart, R.E. (1996) A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Developmental Biology. 180(2):722-731

Xu, Q.L., Alldus, G., Macdonald, R., Wilkinson, D.G., and Holder, N. (1996) Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrain. Nature. 381:319-322

Xu, Q.L., Alldus, G., Holder, N., and Wilkinson, D.G. (1995) Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development (Cambridge, England). 121:4005-4016

Macdonald, R., Barth, K.A., Xu, Q.L., Holder, N., Mikkola, I., and Wilson, S.W. (1995) Midline signalling is required for Pax gene regulation and patterning of the eyes. Development (Cambridge, England). 121:3267-3278

Macdonald, R., Xu, Q., Barth, K.A., Mikkola, I., Holder, N., Fjose, A., Krauss, S., and Wilson, S.W. (1994) Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain. Neuron. 13:1039-1053

Xu, Q., Holder, N., Patient, R., and Wilson, S.W. (1994) Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish. Development (Cambridge, England). 120:287-299