ZFIN ID: ZDB-LAB-100625-2
Thummel Lab
PI/Director: Thummel, Ryan
Contact Person: Thummel, Ryan
Email: rthummel@med.wayne.edu
URL: http://thummellab.weebly.com/
Address: Department of Anatomy and Cell Biology Department of Ophthalmology Wayne State University School of Medicine 8319 Scott Hall 540 E. Canfield Ave. Detroit, MI 48201
Country: United States
Phone: (313) 577-7762
Fax: (313) 577-3125
Line Designation: wsu

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Thomas, Jennifer Graduate Student Luo, Xixia Research Staff Steinmetz, Alexis Research Staff

Kramer, A.C., Carthage, J., Berry, Y., Gurdziel, K., Cook, T.A., Thummel, R. (2023) A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish. Frontiers in cell and developmental biology. 11:12332691233269
Martins, R.R., Zamzam, M., Tracey-White, D., Moosajee, M., Thummel, R., Henriques, C.M., MacDonald, R.B. (2022) Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina. Aging Cell. 21(4):e13597
Magner, E., Sandoval-Sanchez, P., Kramer, A.C., Thummel, R., Hitchcock, P.F., Taylor, S.M. (2022) Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish. Molecular neurobiology. 59(5):2910-2931
Banerjee, S., Ranspach, L.E., Luo, X., Cianciolo, L.T., Fogerty, J., Perkins, B.D., Thummel, R. (2022) Vision and sensorimotor defects associated with loss of Vps11 function in a zebrafish model of genetic leukoencephalopathy. Scientific Reports. 12:3511
Farr, D., Nag, D., Chazin, W.J., Harrison, S., Thummel, R., Luo, X., Raychaudhuri, S., Withey, J.H. (2022) Neutrophil-associated responses to Vibrio cholerae infection in a natural host model. Infection and Immunity. 90(3):e0046621
Kramer, A.C., Gurdziel, K., Thummel, R. (2021) A Comparative Analysis of Gene and Protein Expression Throughout a Full 28-Day Retinal Regeneration Time-Course in Adult Zebrafish. Frontiers in cell and developmental biology. 9:741514
Turkalj, B., Quallich, D., Bessert, D.A., Kramer, A.C., Cook, T.A., Thummel, R. (2021) Development and characterization of a chronic photoreceptor degeneration model in adult zebrafish that does not trigger a regenerative response. Experimental Eye Research. 209:108630
Ang, N.B., Saera-Vila, A., Walsh, C., Hitchcock, P.F., Kahana, A., Thummel, R., Nagashima, M. (2020) Midkine-a functions as a universal regulator of proliferation during epimorphic regeneration in adult zebrafish. PLoS One. 15:e0232308
Mei, F., Rolain, M., Zhou, X.Y., Singh, P.K., Thummel, R., Kumar, A. (2019) Zebrafish are Resistant to Staphylococcus aureus Endophthalmitis. Pathogens (Basel, Switzerland). 8(4):
Shields, J.N., Hales, E.C., Ranspach, L.E., Luo, X., Orr, S., Runft, D., Dombkowski, A., Neely, M.N., Matherly, L.H., Taub, J., Baker, T.R., Thummel, R. (2019) Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11. Toxics. 7(4):
Ranski, A.H., Kramer, A.C., Morgan, G.W., Perez, J.L., Thummel, R. (2018) Characterization of retinal regeneration in adult zebrafish following multiple rounds of phototoxic lesion. PeerJ. 6:e5646
Thomas, J.L., Morgan, G.W., Dolinski, K.M., Thummel, R. (2017) Characterization of the pleiotropic roles of Sonic Hedgehog during retinal regeneration in adult zebrafish. Experimental Eye Research. 166:106-115
Kroeger, P.T., Drummond, B.E., Miceli, R., McKernan, M., Gerlach, G.F., Marra, A.N., Fox, A., McCampbell, K.K., Leshchiner, I., Rodriguez-Mari, A., BreMiller, R., Thummel, R., Davidson, A.J., Postlethwait, J., Goessling, W., Wingert, R.A. (2017) The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Developmental Biology. 428(1):148-163
Granneman, J.G., Kimler, V.A., Zhang, H., Ye, X., Luo, X., Postlethwait, J.H., Thummel, R. (2017) Lipid droplet biology and evolution illuminated by the characterization of a novel Perilipin in teleost fish. eLIFE. 6
Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
Thummel, R., Kathryn Iovine, M. (2017) Using Morpholinos to Examine Gene Function During Fin Regeneration. Methods in molecular biology (Clifton, N.J.). 1565:79-85
Zhang, J., Lachance, V., Schaffner, A., Li, X., Fedick, A., Kaye, L.E., Liao, J., Rosenfeld, J., Yachelevich, N., Chu, M.L., Mitchell, W.G., Boles, R.G., Moran, E., Tokita, M., Gorman, E., Bagley, K., Zhang, W., Xia, F., Leduc, M., Yang, Y., Eng, C., Wong, L.J., Schiffmann, R., Diaz, G.A., Kornreich, R., Thummel, R., Wasserstein, M., Yue, Z., Edelmann, L. (2016) A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects. PLoS Genetics. 12:e1005848
Thomas, J.L., Ranski, A.H., Morgan, G.W., Thummel, R. (2016) Reactive Gliosis in the Adult Zebrafish Retina. Experimental Eye Research. 143:98-109
Taylor, S.M., Alvarez-Delfin, K., Saade, C.J., Thomas, J.L., Thummel, R., Fadool, J.M., Hitchcock, P.F. (2015) The bHLH Transcription Factor NeuroD Governs Photoreceptor Genesis and Regeneration Through Delta-Notch Signaling. Investigative ophthalmology & visual science. 56:7496-7515
Gramage, E., D'Cruz, T., Taylor, S., Thummel, R., Hitchcock, P.F. (2015) Midkine-a Protein Localization in the Developing and Adult Retina of the Zebrafish and Its Function During Photoreceptor Regeneration. PLoS One. 10:e0121789
Thomas, J.L., and Thummel, R. (2013) A novel light damage paradigm for use in retinal regeneration studies in adult zebrafish. Journal of visualized experiments : JoVE. (80):e51017
Lenkowski, J.R., Qin, Z., Sifuentes, C.J., Thummel, R., Soto, C.M., Moens, C.B., Raymond, P.A.. (2013) Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling. Glia. 61(10):1687-1697
Thomas, J.L., Nelson, C.M., Luo, X., Hyde, D.R., and Thummel, R. (2012) Characterization of multiple light damage paradigms reveals regional differences in photoreceptor loss. Experimental Eye Research. 97(1):105-116
Hyde, D.R., Godwin, A.R., and Thummel, R. (2012) In vivo Electroporation of Morpholinos into the Regenerating Adult Zebrafish Tail Fin. Journal of visualized experiments : JoVE. (61)
Thomas, J.L., Ochocinska, M.J., Hitchcock, P.F., and Thummel, R. (2012) Using the Tg(nrd:egfp)/albino Zebrafish Line to Characterize In Vivo Expression of neurod. PLoS One. 7(1):e29128
Thummel, R., Bailey, T.J., and Hyde, D.R. (2011) In vivo Electroporation of Morpholinos into the Adult Zebrafish Retina. Journal of visualized experiments : JoVE. (58):e3603
Qin, Z., Kidd, A.R., Thomas, J.L., Poss, K.D., Hyde, D.R., Raymond, P.A., and Thummel, R. (2011) FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. Experimental Eye Research. 93(5):726-34
Thomas, J.L., Vihtelic, T.S., Dendekker, A.D., Willer, G., Luo, X., Murphy, T.R., Gregg, R.G., Hyde, D.R., and Thummel, R. (2011) The loss of vacuolar protein sorting 11 (vps11) causes retinal pathogenesis in a vertebrate model of syndromic albinism. Investigative ophthalmology & visual science. 52(6):3119-28
Craig, S.E., Thummel, R., Ahmed, H., Vasta, G.R., Hyde, D., and Hitchcock, P.F. (2010) The Zebrafish Galectin Drgal1-L2 Is Expressed by Proliferating Müller Glia and Photoreceptor Progenitors and Regulates the Regeneration of Rod Photoreceptors. Investigative ophthalmology & visual science. 51(6):3244-3252
Thummel, R., Enright, J.M., Kassen, S.C., Montgomery, J.E., Bailey, T.J., and Hyde, D.R. (2010) Pax6a and Pax6b are required at different points in neuronal progenitor cell proliferation during zebrafish photoreceptor regeneration. Experimental Eye Research. 90(5):572-582
Kassen, S.C., Thummel, R., Campochiaro, L.A., Harding, M.J., Bennett, N.A., and Hyde, D.R. (2009) CNTF induces photoreceptor neuroprotection and Müller glial cell proliferation through two different signaling pathways in the adult zebrafish retina. Experimental Eye Research. 88(6):1051-1064
Thummel, R., Kassen, S.C., Enright, J.M., Nelson, C.M., Montgomery, J.E., and Hyde, D.R. (2008) Characterization of Müller glia and neuronal progenitors during adult zebrafish retinal regeneration. Experimental Eye Research. 87(5):433-444
Kassen, S.C., Thummel, R., Burket, C.T., Campochiaro, L.A., Harding, M.J., and Hyde, D.R. (2008) The Tg(ccnb1:EGFP) transgenic zebrafish line labels proliferating cells during retinal development and regeneration. Molecular Vision. 14:951-963
Hoptak-Solga, A.D., Nielsen, S., Jain, I., Thummel, R., Hyde, D.R., and Iovine, M.K. (2008) Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. Developmental Biology. 317(2):541-548
Burket, C.T., Montgomery, J.E., Thummel, R., Kassen, S.C., Lafave, M.C., Langenau, D.M., Zon, L.I., and Hyde, D.R. (2008) Generation and characterization of transgenic zebrafish lines using different ubiquitous promoters. Transgenic Research. 17(2):265-279
Yin, V.P., Thomson, J.M., Thummel, R., Hyde, D.R., Hammond, S.M., and Poss, K.D. (2008) Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish. Genes & Development. 22(6):728-733
Thummel, R., Kassen, S.C., Montgomery, J.E., Enright, J.M., and Hyde, D.R. (2008) Inhibition of Müller glial cell division blocks regeneration of the light-damaged zebrafish retina. Developmental Neurobiology. 68(3):392-408
Thummel, R., Ju, M., Sarras, M.P. Jr., and Godwin, A.R. (2007) Both Hoxc13 orthologs are functionally important for zebrafish tail fin regeneration. Development genes and evolution. 217(6):413-420
Thummel, R., Burket, C.T., and Hyde, D.R. (2006) Two different transgenes to study gene silencing and re-expression during zebrafish caudal fin and retinal regeneration. TheScientificWorldJournal. 6(1):65-81
Thummel, R., Bai, S., Sarras, M.P. Jr, Song, P., McDermott, J., Brewer, J., Perry, M., Zhang, X., Hyde, D.R., and Godwin, A.R. (2006) Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(2):336-346
Thummel, R., Burket, C.T., Brewer, J.L., Sarras, M.P. Jr., Li, L., Perry, M., McDermott, J.P., Sauer, B., Hyde, D.R., and Godwin, A.R. (2005) Cre-mediated site-specific recombination in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(4):1366-1377
Bai, S., Thummel, R., Godwin, A.R., Nagase, H., Itoh, Y., Li, L., Evans, R., McDermott, J., Seiki, M., and Sarras, M.P. Jr. (2005) Matrix metalloproteinase expression and function during fin regeneration in zebrafish: Analysis of MT1-MMP, MMP2 and TIMP2. Matrix biology : journal of the International Society for Matrix Biology. 24(4):247-260
Thummel, R., Li, L., Tanase, C., Sarras, M.P. Jr., and Godwin, A.R. (2004) Differences in expression pattern and function between zebrafish hoxc13 orthologs: recruitment of Hoxc13b into an early embryonic role. Developmental Biology. 274(2):318-333
Thummel, R. (2004) Genetic analysis of Hoxc13 orthologs in mice and zebrafish. Ph.D. Thesis. :200P
Thummel, R., Li, L., Sarras, M.P., and Godwin, A.R. (2002) Hoxc13 orthologs in zebrafish. Developmental Biology. 247(2):445