ZFIN ID: ZDB-LAB-061018-1
McCallion Lab
PI/Director: McCallion, Andy
Contact Person: McCallion, Andy
Email: andy@jhmi.edu
URL: http://www.hopkinsmedicine.org/geneticmedicine/
Address: McKusick-Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine BRB Room 407 733 N. Broadway Baltimore MD 21205-1832 USA
Country: United States
Phone: (410)-502-7533 (Lab)
Fax: (410)-502-5677
Line Designation: jh


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show first 50 of 77 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Duong, T., Rose, R., Blazeski, A., Fine, N., Woods, C.E., Thole, J.F., Sotoodehnia, N., Soliman, E.Z., Tung, L., McCallion, A.S., Arking, D.E. (2021) Development and optimization of an in vivo electrocardiogram recording method and analysis program for adult zebrafish. Disease models & mechanisms. 14(8):
Edelman, H.E., McClymont, S.A., Tucker, T.R., Pineda, S., Beer, R.L., McCallion, A.S., Parsons, M.J. (2021) SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer. Human molecular genetics. 30(6):485-499
Gould, R.A., Aziz, H., Woods, C.E., Seman-Senderos, M.A., Sparks, E., Preuss, C., Wünnemann, F., Bedja, D., Moats, C.R., McClymont, S.A., Rose, R., Sobreira, N., Ling, H., MacCarrick, G., Kumar, A.A., Luyckx, I., Cannaerts, E., Verstraeten, A., Björk, H.M., Lehsau, A.C., Jaskula-Ranga, V., Lauridsen, H., Shah, A.A., Bennett, C.L., Ellinor, P.T., Lin, H., Isselbacher, E.M., Lino Cardenas, C.L., Butcher, J.T., Hughes, G.C., Lindsay, M.E., Baylor-Hopkins Center for Mendelian Genomics, MIBAVA Leducq Consortium, Mertens, L., Franco-Cereceda, A., Verhagen, J.M.A., Wessels, M., Mohamed, S.A., Eriksson, P., Mital, S., Van Laer, L., Loeys, B.L., Andelfinger, G., McCallion, A.S., Dietz, H.C. (2019) ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm. Nature Genetics. 51:42-50
McClymont, S.A., Hook, P.W., Soto, A.I., Reed, X., Law, W.D., Kerans, S.J., Waite, E.L., Briceno, N.J., Thole, J.F., Heckman, M.G., Diehl, N.N., Wszolek, Z.K., Moore, C.D., Zhu, H., Akiyama, J.A., Dickel, D.E., Visel, A., Pennacchio, L.A., Ross, O.A., Beer, M.A., McCallion, A.S. (2018) Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons. American journal of human genetics. 103(6):874-892
Edie, S., Zaghloul, N.A., Leitch, C.C., Klinedinst, D.K., Lebron, J., Thole, J.F., McCallion, A.S., Katsanis, N., Reeves, R.H. (2018) Survey of Human Chromosome 21 Gene Expression Effects on Early Development in Danio rerio.. G3 (Bethesda). 8(7):2215-2223
Fischer, A., Wolman, M., Granato, M., Parsons, M., McCallion, A.S., Proescher, J., English, E. (2015) Carbamate nerve agent prophylatics exhibit distinct toxicological effects in the zebrafish embryo model. Neurotoxicology and teratology. 50:1-10
Jiang, Q., Arnold, S., Heanue, T., Kilambi, K.P., Doan, B., Kapoor, A., Ling, A.Y., Sosa, M.X., Guy, M., Jiang, Q., Burzynski, G., West, K., Bessling, S., Griseri, P., Amiel, J., Fernandez, R.M., Verheij, J.B., Hofstra, R.M., Borrego, S., Lyonnet, S., Ceccherini, I., Gray, J.J., Pachnis, V., McCallion, A.S., Chakravarti, A. (2015) Functional Loss of Semaphorin 3C and/or Semaphorin 3D and Their Epistatic Interaction with Ret Are Critical to Hirschsprung Disease Liability. American journal of human genetics. 96:581-596
Liu, Y., Pham, X., Zhang, L., Chen, P.L., Burzynski, G., McGaughey, D.M., He, S., McGrath, J.A., Wolyniec, P., Fallin, M.D., Pierce, M.S., McCallion, A.S., Pulver, A.E., Avramopoulos, D., Valle, D. (2014) Functional Variants in DPYSL2 Sequence Increase Schizophrenia Risk and Suggest a Link to mTOR Signaling. G3 (Bethesda). 5(1):61-72
Maragh, S., Miller, R.A., Bessling, S.L., Wang, G., Hook, P.W., McCallion, A.S. (2014) Rbm24a and Rbm24b Are Required for Normal Somitogenesis. PLoS One. 9:e105460
Praetorius, C., Grill, C., Stacey, S.N., Metcalf, A.M., Gorkin, D.U., Robinson, K.C., Van Otterloo, E., Kim, R.S., Bergsteinsdottir, K., Ogmundsdottir, M.H., Magnusdottir, E., Mishra, P.J., Davis, S.R., Guo, T., Zaidi, M.R., Helgason, A.S., Sigurdsson, M.I., Meltzer, P.S., Merlino, G., Petit, V., Larue, L., Loftus, S.K., Adams, D.R., Sobhiafshar, U., Emre, N.C., Pavan, W.J., Cornell, R., Smith, A.G., McCallion, A.S., Fisher, D.E., Stefansson, K., Sturm, R.A., and Steingrimsson, E. (2013) A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway. Cell. 155(5):1022-1033
Burzynski, G.M., Reed, X., Maragh, S., Matsui, T., and McCallion, A.S. (2013) Integration of genomic and functional approaches reveals enhancers at LMX1A and LMX1B. Molecular genetics and genomics : MGG. 288(11):579-89
Burzynski, G., Reed, X., Taher, L., Stine, Z.E., Matsui, T., Ovcharenko, I., and McCallion, A.S. (2012) Systematic elucidation and in vivo validation of sequences enriched in hindbrain transcriptional control. Genome research. 22(11):2278-2289
Doyle, A.J., Doyle, J.J., Bessling, S.L., Maragh, S., Lindsay, M.E., Schepers, D., Gillis, E., Mortier, G., Homfray, T., Sauls, K., Norris, R.A., Huso, N.D., Leahy, D., Mohr, D.W., Caulfield, M.J., Scott, A.F., Destrée, A., Hennekam, R.C., Arn, P.H., Curry, C.J., Van Laer, L., McCallion, A.S., Loeys, B.L., and Dietz, H.C. (2012) Mutations in the TGF-beta repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. Nature Genetics. 44(11):1249-1254
Gorkin, D.U., Lee, D., Reed, X., Fletez-Brant, C., Bessling, S.L., Loftus, S.K., Beer, M.A., Pavan, W.J., and McCallion, A.S. (2012) Integration of ChIP-seq and machine learning reveals enhancers and a predictive regulatory sequence vocabulary in melanocytes. Genome research. 22(11):2290-2301
Harden, M.V., Pereiro, L., Ramialison, M., Wittbrodt, J., Prasad, M.K., McCallion, A.S., and Whitlock, K.E. (2012) Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(7):1143-1154
Maragh, S., Miller, R.A., Bessling, S.L., McGaughey, D.M., Wessels, M.W., de Graaf, B., Stone, E.A., Bertoli-Avella, A.M., Gearhart, J.D., Fisher, S., and McCallion, A.S. (2011) Identification of RNA binding motif proteins essential for cardiovascular development. BMC Developmental Biology. 11(1):62
Stine, Z.E., McGaughey, D.M., Bessling, S.L., Li, S., and McCallion, A.S. (2011) Steroid hormone modulation of RET through two estrogen responsive enhancers in breast cancer. Human molecular genetics. 20(19):3746-56
Taher, L., McGaughey, D.M., Maragh, S., Aneas, I., Bessling, S.L., Miller, W., Nobrega, M.A., McCallion, A.S., and Ovcharenko, I. (2011) Genome-wide identification of conserved regulatory function in diverged sequences. Genome research. 21(7):1139-49
Prasad, M.K., Reed, X., Gorkin, D.U., Cronin, J.C., McAdow, A.R., Chain, K., Hodonsky, C.J., Jones, E.A., Svaren, J.P., Antonellis, A., Johnson, S.L., Loftus, S.K., Pavan, W.J., and McCallion, A.S. (2011) SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer. BMC Developmental Biology. 11(1):40
Antonellis, A., Dennis, M.Y., Burzynski, G., Huynh, J., Maduro, V., Hodonsky, C.J., Khajavi, M., Szigeti, K., Mukkamala, S., Bessling, S.L.; NISC Comparative Sequencing Program, Pavan, W.J., McCallion, A.S., Lupski, J.R., and Green, E.D. (2010) A Rare Myelin Protein Zero (MPZ) Variant Alters Enhancer Activity In Vitro and In Vivo. PLoS One. 5(12):e14346
McGaughey, D.M., and McCallion, A.S. (2010) Efficient discovery of ASCL1 regulatory sequences through transgene pooling. Genomics. 95(6):363-369
McGaughey, D.M., Stine, Z.E., Huynh, J.L., Vinton, R.M., and McCallion, A.S. (2009) Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trend. BMC Genomics. 10:8
Antonellis, A., Huynh, J.L., Lee-Lin, S.Q., Vinton, R.M., Renaud, G., Loftus, S.K., Elliot, G., Wolfsberg, T.G., Green, E.D., McCallion, A.S., and Pavan, W.J. (2008) Identification of Neural Crest and Glial Enhancers at the Mouse Sox10 Locus through Transgenesis in Zebrafish. PLoS Genetics. 4(9):e1000174
McGaughey, D.M., Vinton, R.M., Huynh, J., Al-Saif, A., Beer, M.A., and McCallion, A.S. (2008) Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b. Genome research. 18(2):252-260
Xie, J., Bessling, S.L., Cooper, T.K., Dietz, H.C., McCallion, A.S., and Fisher, S. (2007) Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics. 176(2):1339-1342
Fisher, S., Grice, E.A., Vinton, R.M., Bessling, S.L., Urasaki, A., Kawakami, K.,and McCallion, A.S. (2006) Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish. Nature Protocols. 1(3):1297-1305
Emison, E.S., McCallion, A.S., Kashuk, C.S., Bush, R.T., Grice, E., Lin, S., Portnoy, M.E., Cutler, D.J., Green, E.D., and Chakravarti, A. (2005) A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk. Nature. 434:857-863