ZFIN ID: ZDB-LAB-060228-1
Henry Lab
PI/Director: Henry, Clarissa A.
Contact Person: Henry, Clarissa A.
Email: Clarissa.Henry@umit.maine.edu
URL: http://biology.umaine.edu/run.php?pg=User&user_id=70
Address: 217 Hitchner Hall University of Maine Orono, ME 04469-5735 USA
Country: United States
Phone: 207-581-2816
Fax: 207-581-2537
Line Designation: mai

Show all 6 genomic features

A large variety of diseases, both inherited and acquired, affect muscle tissues in humans. In order to prevent and/or treat such disease, it is necessary to understand the pathology at the cellular and molecular level. Because each step of muscle specification and differentiation translates to a progressive refinement of functional physiology, studying muscle development may lead to therapeutic insights. The goal of our laboratory is to elucidate the signaling networks that underlie muscle morphogenesis.

Jones, Robert Graduate Student Ladd, Emma Graduate Student McNulty, Ian Graduate Student
Nilan, Mark Fish Facility Staff

Karuppasamy, M., English, K.G., Henry, C.A., Manzini, M.C., Parant, J.M., Wright, M.A., Ruparelia, A.A., Currie, P.D., Gupta, V.A., Dowling, J.J., Maves, L., Alexander, M.S. (2024) Standardization of zebrafish drug testing parameters for muscle diseases. Disease models & mechanisms. 17(1):
Shivanna, K., Astumian, M., Raut, P., Ngo, V.N., Hess, S.T., Henry, C. (2023) Super-Resolution Imaging Reveals the Nanoscale Distributions of Dystroglycan and Integrin Itga7 in Zebrafish Muscle Fibers. Biomedicines. 11(7):
Kilroy, E.A., Ignacz, A.C., Brann, K.L., Schaffer, C.E., Varney, D., Alrowaished, S.S., Silknitter, K.J., Miner, J.N., Almaghasilah, A., Spellen, T.L., Lewis, A.D., Tilbury, K., King, B.L., Kelley, J.B., Henry, C.A. (2022) Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy. eLIFE. 11:
Coffey, E.C., Astumian, M., Alrowaished, S.S., Schaffer, C., Henry, C.A. (2021) Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix. Journal of developmental biology. 9(4):
Farr, G.H., Morris, M., Gomez, A., Pham, T., Kilroy, E., Parker, E.U., Said, S., Henry, C., Maves, L. (2020) A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skeletal muscle. 10:29
Bailey, E.C., Alrowaished, S.S., Kilroy, E.A., Crooks, E.S., Drinkert, D.M., Karunasiri, C.M., Belanger, J.J., Khalil, A., Kelley, J.B., Henry, C.A. (2019) NAD+ improves neuromuscular development in a zebrafish model of FKRP-associated dystroglycanopathy. Skeletal muscle. 9:21
Glenn, N.O., Henry, C.A. (2019) How muscle contraction strengthens tendons. eLIFE. 8
Coffey, E.C., Pasquarella, M.E., Goody, M.F., Henry, C.A. (2018) Ethanol Exposure Causes Muscle Degeneration in Zebrafish. Journal of developmental biology. 6(1)
Goody, M., Jurczyszak, D., Kim, C., Henry, C. (2017) Influenza A Virus Infection Damages Zebrafish Skeletal Muscle and Exacerbates Disease in Zebrafish Modeling Duchenne Muscular Dystrophy. PLoS Currents. 9
Goody, M.F., Carter, E.V., Kilroy, E.A., Maves, L., Henry, C.A. (2017) "Muscling" Throughout Life: Integrating Studies of Muscle Development, Homeostasis, and Disease in Zebrafish. Current topics in developmental biology. 124:197-234
Jenkins, M.H., Alrowaished, S.S., Goody, M.F., Crawford, B.D., Henry, C.A. (2016) Laminin and Matrix metalloproteinase 11 regulate Fibronectin levels in the zebrafish myotendinous junction. Skeletal muscle. 6:18
Goody, M.F., Kelly, M.W., Reynolds, C.J., Khalil, A., Crawford, B.D., and Henry, C.A. (2012) NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy. PLoS Biology. 10(10):e1001409
Goody, M.F., Kelly, M.W., Lessard, K.N., Khalil, A., and Henry, C.A. (2010) Nrk2b-mediated NAD+ production regulates cell adhesion and is required for muscle morphogenesis in vivo: Nrk2b and NAD+ in muscle morphogenesis. Developmental Biology. 344(2):809-826
Peterson, M.T., and Henry, C.A. (2010) Hedgehog signaling and laminin play unique and synergistic roles in muscle development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(3):905-913
Snow, C.J., and Henry, C.A. (2009) Dynamic formation of microenvironments at the myotendinous junction correlates with muscle fiber morphogenesis in zebrafish. Gene expression patterns : GEP. 9(1):37-42
Snow, C.J., Goody, M., Kelly, M.W., Oster, E.C., Jones, R., Khalil, A., and Henry, C.A. (2008) Time-lapse analysis and mathematical characterization elucidate novel mechanisms underlying muscle morphogenesis. PLoS Genetics. 4(10):e1000219
Snow, C.J., Peterson, M.T., Khalil, A., and Henry, C.A. (2008) Muscle development is disrupted in zebrafish embryos deficient for fibronectin. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(9):2542-2553
Kok, F.O., Oster, E., Mentzer, L., Hsieh, J.C., Henry, C.A., and Sirotkin, H.I. (2007) The role of the SPT6 chromatin remodeling factor in zebrafish embryogenesis. Developmental Biology. 307(2):214-226
Henry, C.A., McNulty, I.M., Durst, W.A., Munchel, S.E., and Amacher, S.L. (2005) Interactions between muscle fibers and segment boundaries in zebrafish. Developmental Biology. 287(2):346-360
Henry, C.A., Poage, C.T., McCarthy, M.B., Campos-Ortega, J., and Cooper, M.S. (2005) Regionally Autonomous Segmentation Within Zebrafish Presomitic Mesoderm. Zebrafish. 2(1):7-18
Henry, C.A., and Amacher, S.L. (2004) Zebrafish slow muscle cell migration induces a wave of fast muscle morphogenesis. Developmental Cell. 7(6):917-923
Crawford, B.D., Henry, C.A., Clason, T.A., Becker, A.L., and Hille, M.B. (2003) Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis. Molecular biology of the cell. 14(8):3065-3081
Henry, C.A., Urban, M.K., Dill, K.K., Merlie, J.P., Page, M.F., Kimmel, C.B., and Amacher, S.L. (2002) Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries. Development (Cambridge, England). 129(15):3693-3704
Henry, C.A., Crawford, B.D., Yan, Y.-L., Postlethwait, J., Cooper, M.S., and Hille, M.B. (2001) Roles for zebrafish focal adhesion kinase in notochord and somite morphogenesis. Developmental Biology. 240(2):474-487
Henry, C.A., Crawford, B.D., Sepich, D., Cooper, M.S., and Hille, M. (2000) Subcellular localization of focal adhesion kinase during zebrafish organogenesis: Distinct roles for FAK in notochord and somite morphogenesis. Molecular biology of the cell. 11:297
Henry, C.A., Hall, L.A., Hille, M.B., Solnica-Krezel, L., and Cooper, M.S. (2000) Somites in zebrafish doubly mutant for knypek and trilobite form without internal mesenchymal cells or compaction. Current biology : CB. 10(17):1063-1066
Henry, C.A. (2000) Somitogenesis in zebrafish. Ph.D. Thesis.
Cooper, M.S., D'Amico, L.A., and Henry, C.A. (1999) Confocal microscopic analysis of morphogenetic movements. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:179-204
Cooper, M.S., D'Amico, L.A., and Henry, C.A. (1999) Analyzing morphogenetic cell behaviors in vitally stained zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 122:185-204