ZFIN Lab: Xia Lab

ZFIN ID: ZDB-LAB-051219-1

Xia Lab

PI/Director:	Xia, Weiming
Contact Person:	Xia, Weiming
Email:	wxia@rics.bwh.harvard.edu
URL:
Address:	Harvard Institute of Medicine, HIM 616 77 Ave Louis Pasteur Boston, MA 02115
Country:	United States
Phone:	617-525-5212
Fax:	617-525-5190
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Liu, Wei Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Du, J., Zhang, D., Zhang, W., Ouyang, G., Wang, J., Liu, X., Li, S., Ji, W., Liu, W., Xiao, W. (2015) pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation. Journal of immunology (Baltimore, Md. : 1950). 195(4):1782-90

Zhang, W., Liu, W., Li, P., Kang, J., Wang, J., Wang, H., Tang, B. (2015) Reversible two-photon fluorescent probe for imaging of hypochlorous acid in live cells and in vivo. Chemical communications (Cambridge, England). 51(50):10150-3

Wang, K., Fang, X., Ma, N., Lin, Q., Huang, Z., Liu, W., Xu, M., Chen, X., Zhang, W., Zhang, Y. (2015) Myeloperoxidase-deficient Zebrafish show an Augmented Inflammatory Response to Challenge with Candida albicans. Fish & shellfish immunology. 44(1):109-16

Yan, L., Zhou, Y., Yu, S., Ji, G., Wang, L., Liu, W., and Gu, A. (2013) 8-Oxoguanine DNA glycosylase 1 (ogg1) maintains the function of cardiac progenitor cells during heart formation in zebrafish. Experimental cell research. 319(19):2954-63

Zhang, J., Zhang, Y., Liu, W., Quan, X., Chen, S., Zhao, H., Jin, Y., and Zhang, W. (2013) Evaluation of removal efficiency for acute toxicity and genotoxicity on zebrafish in anoxic-oxic process from selected municipal wastewater treatment plants. Chemosphere. 90(11):2662-2666

Xia, S., Zhu, Y., Xu, X., and Xia, W. (2013) Computational Techniques in Zebrafish Image Processing and Analysis. Journal of Neuroscience Methods. 213(1):6-13

Chen, J., Chen, Y., Liu, W., Bai, C., Liu, X., Liu, K., Li, R., Zhu, J.H., and Huang, C. (2012) Developmental lead acetate exposure induces embryonic toxicity and memory deficit in adult zebrafish. Neurotoxicology and teratology. 34(6):581-586

Wang, K., Huang, Z., Zhao, L., Liu, W., Chen, X., Meng, P., Lin, Q., Chi, Y., Xu, M., Ma, N., Zhang, Y., and Zhang, W. (2012) Large-scale forward genetic screening analysis of development of hematopoiesis in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):473-480

Wei, Y., Li, P., Fan, H., Sun, E., Wang, C., Shu, L., Liu, W., Xue, X., Qian, Q., and Jia, X. (2012) Metabolite profiling of four major flavonoids of herba epimdii in zebrafish. Molecules. 17(1):420-432

He, J., Yang, D., Wang, C., Liu, W., Liao, J., Xu, T., Bai, C., Chen, J., Lin, K., Huang, C., and Dong, Q. (2011) Chronic zebrafish low dose decabrominated diphenyl ether (BDE-209) exposure affected parental gonad development and locomotion in F1 offspring. Ecotoxicology (London, England). 20(8):1813-22

Pei, D.S., Yang, X.J., Liu, W., Guikema, J.E., Schrader, C.E., and Strauss, P.R. (2011) A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic acids research. 39(8):3156-3165

Ma, N., Huang, Z., Chen, X., He, F., Wang, K., Liu, W., Zhao, L., Xu, X., Liao, W., Ruan, H., Luo, S., and Zhang, W. (2011) Characterization of a Weak Allele of Zebrafish cloche Mutant. PLoS One. 6(11):e27540

Xu, X., Xu, X., Huang, X., Xia, W., and Xia, S. (2010) A high-throughput analysis method to detect regions of interest and quantify zebrafish embryo images. Journal of Biomolecular Screening. 15(9):1152-1159

Yang, T., Arslanova, D., Xu, X., Li, Y.M., and Xia, W. (2010) In Vivo Manifestation of Notch Related Phenotypes in Zebrafish Treated with Alzheimer's Amyloid Reducing gamma-Secretase Inhibitors. Journal of neurochemistry. 113(5):1200-1209

Arslanova, D., Yang, T., Xu, X., Wong, S.T., Augelli-Szafran, C.E., and Xia, W. (2010) Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors. BMC Biotechnology. 10:24

Xia, W. (2010) Exploring Alzheimer's Disease in Zebrafish. Journal of Alzheimer's disease : JAD. 20(4):981-990

Zhao, H., Cui, K., Xia, W., and Wong, S.T.C. (2009) A new platform using bioluminescence imaging and zebrafish xenograft. Application in [gamma]-secretase inhibitors affect tumorigenesis. Texas and Southern Plains Zebrafish Meeting.

Sun, H., Skogerbo, G., Zheng, X., Liu, W., and Li, Y. (2009) Genomic regions with distinct genomic distance conservation in vertebrate genomes. BMC Genomics. 10:133

Baulac, S., Lu, H., Strahle, J., Yang, T., Goldberg, M.S., Shen, J., Schlossmacher, M.G., Lemere, C.A., Lu, Q., and Xia, W. (2009) Increased DJ-1 Expression under Oxidative Stress and in Alzheimer's Disease Brains. Molecular neurodegeneration. 4:12

Yang, T., Arslanova, D., Gu, Y., Augelli-Szafran, C., and Xia, W. (2008) Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein. Molecular brain. 1(1):15

Geng, X., Speirs, C., Lagutin, O., Inbal, A., Liu, W., Solnica-Krezel, L., Jeong, Y., Epstein, D.J., and Oliver, G. (2008) Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Developmental Cell. 15(2):236-247

Lu, Z., Liu, W., Huang, H., He, Y., Han, Y., Wang, Y., Li, Q., Ruan, K., Ye, Z., Low, B.C., Meng, A., and Lin, S.C. (2008) Protein encoded by the AxinFu allele effectively downregulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. The Journal of biological chemistry. 283(19):13132-13139

Liu, T., Li, G., Nie, J., Tarokh, A., Zhou, X., Guo, L., Malicki, J., Xia, W., and Wong, S.T. (2008) An Automated Method for Cell Detection in Zebrafish. Neuroinformatics. 6(1):5-21

Sun, H., Skogerbo, G., Wang, Z., Liu, W., and Li, Y. (2008) Structural relationships between highly conserved elements and genes in vertebrate genomes. PLoS One. 3(11):e3727

Li, G., Liu, T., Nie, J., Guo, L., Malicki, J., Mara, A., Holley, S.A., Xia, W., and Wong, S.T. (2007) Detection of blob objects in microscopic zebrafish images based on gradient vector diffusion. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 71(10):835-845

Zetterberg, H., Campbell, W.A., Yang, H.W., and Xia, W. (2006) The Cytosolic Loop of the γ-Secretase Component Presenilin Enhancer 2 Protects Zebrafish Embryos from Apoptosis. The Journal of biological chemistry. 281(17):11933-11939

Campbell, W.A., Yang, H., Zetterberg, H., Baulac, S., Sears, J.A., Liu, T., Wong, S.T., Zhong, T.P., and Xia, W. (2006) Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. Journal of neurochemistry. 96(5):1423-1440