ZFIN Lab: Roberts Lab

ZFIN ID: ZDB-LAB-020619-2

Roberts Lab

PI/Director:	Roberts, Thomas M.
Contact Person:	Roberts, Thomas M.
Email:	thomas_roberts@dfci.harvard.edu
URL:
Address:	Department of Cancer Biology Dana-Farber Cancer Institute Harvard Medical School Smith 970 44 Binney Street Boston, MA 02115 USA
Country:	United States
Phone:	(617) 632-3049
Fax:	(617) 632-4770
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 8 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Sarkissian, Madathia Post-Doc	Uchiyama, Junzo Post-Doc	Wang, Jian Graduate Student
Bayliss, Peter Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Liu, L., Yan, Y., Wang, J., Wu, W., Xu, L. (2016) Generation of mt:egfp transgenic zebrafish biosensor for the detection of aquatic zinc and cadmium. Environmental toxicology and chemistry. 35(8):2066-73

Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952

Wang, J., Song, Q., Yu, D., Yang, G., Xia, L., Su, K., Shi, H., Wang, J., Yin, S. (2015) Ontogenetic development of the auditory sensory organ in zebrafish (Danio rerio): changes in hearing sensitivity and related morphology. Scientific Reports. 5:15943

Chen, X., Wang, J., Cao, Z., Hosaka, K., Jensen, L., Yang, H., Sun, Y., Zhuang, R., Liu, Y., Cao, Y. (2015) Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model. Scientific Reports. 5:10351

Yang, X., Zhang, Y., Hosaka, K., Andersson, P., Wang, J., Tholander, F., Cao, Z., Morikawa, H., Tegnér, J., Yang, Y., Iwamoto, H., Lim, S., Cao, Y. (2015) VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 112:E2900-9

Wang, J., Cao, Z., Zhang, X.M., Nakamura, M., Sun, M., Hartman, J., Harris, R.A., Sun, Y., Cao, Y. (2015) Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development. Cancer research. 75(2):306-15

Liu, L., Xu, Y., Xu, L., Wang, J., Wu, W., Xu, L., Yan, Y. (2015) Analysis of differentially expressed proteins in zebrafish (Danio rerio) embryos exposed to chlorpyrifos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 167C:183-189

Sasaki, T., Lian, S., Qi, J., Bayliss, P.E., Carr, C.E., Johnson, J.L., Guha, S., Kobler, P., Catz, S.D., Gill, M., Jia, K., Klionsky, D.J., Kishi, S. (2014) Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency. PLoS Genetics. 10:e1004409

Xu, J., Ji, P., Wang, B., Zhao, L., Wang, J., Zhao, Z., Zhang, Y., Li, J., Xu, P., and Sun, X. (2013) Transcriptome Sequencing and Analysis of Wild Amur Ide (Leuciscus waleckii) Inhabiting an Extreme Alkaline-Saline Lake Reveals Insights into Stress Adaptation. PLoS One. 8(4):e59703

Li, Y., Xu, P., Zhao, Z., Wang, J., Zhang, Y., and Sun, X.W. (2011) Construction and Characterization of the BAC Library for Common Carp Cyprinus Carpio L. And Establishment of Microsynteny with Zebrafish Danio Rerio. Marine biotechnology (New York, N.Y.). 13(4):706-12

Cui, Y., He, S., Xing, C., Lu, K., Wang, J., Xing, G., Meng, A., Jia, S., He, F., and Zhang, L. (2011) SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT‐type ubiquitin ligase Smurf1. The EMBO journal. 30(13):2675-89

Qi, H.H., Sarkissian, M., Hu, G.Q., Wang, Z., Bhattacharjee, A., Gordon, D.B., Gonzales, M., Lan, F., Ongusaha, P.P., Huarte, M., Yaghi, N.K., Lim, H., Garcia, B.A., Brizuela, L., Zhao, K., Roberts, T.M., and Shi, Y. (2010) Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature. 466(7305):503-507

Kishi, S., Slack, B.E., Uchiyama, J., and Zhdanova, I.V. (2009) Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review. Gerontology. 55(4):430-441

Kishi, S., Bayliss, P.E., Uchiyama, J., Koshimizu, E., Qi, J., Nanjappa, P., Imamura, S., Islam, A., Neuberg, D., Amsterdam, A., and Roberts, T.M. (2008) The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genetics. 4(8):e1000152

Imamura, S., Uchiyama, J., Koshimizu, E., Hanai, J., Raftopoulou, C., Murphey, R.D., Bayliss, P.E., Imai, Y., Burns, C.E., Masutomi, K., Gagos, S., Zon, L.I., Roberts, T.M., and Kishi, S. (2008) A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 3(10):e3364

Lan, F., Bayliss, P.E., Rinn, J.L., Whetstine, J.R., Wang, J.K., Chen, S., Iwase, S., Alpatov, R., Issaeva, I., Canaani, E., Roberts, T.M., Chang, H.Y., and Shi, Y. (2007) A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 449(7163):689-694

Tsai, S.B., Tucci, V., Uchiyama, J., Fabian, N.J., Lin, M.C., Bayliss, P.E., Neuberg, D.S., Zhdanova, I.V., and Kishi, S. (2007) Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish. Aging Cell. 6(2):209-224

Iwase, S., Lan, F., Bayliss, P., de la Torre-Ubieta, L., Huarte, M., Qi, H.H., Whetstine, J.R., Bonni, A., Roberts, T.M., and Shi, Y. (2007) The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 128(6):1077-1088

Ho, D.M., Chan, J., Bayliss, P., and Whitman, M. (2006) Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo. Developmental Biology. 295(2):730-742

Bayliss, P.E., Bellavance, K.L., Whitehead, G.G., Abrams, J.M., Aegerter, S., Robbins, H.S., Cowan, D.B., Keating, M.T., O'reilly, T., Wood, J.M., Roberts, T.M., and Chan, J. (2006) Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nature Chemical Biology. 2(5):265-273

Montero, J.-A., Killan, B., Chan, J., Bayliss, P.E., and Heisenberg, C.-P. (2003) Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. Current biology : CB. 13(15):1279-1289

Kishi, S., Uchiyama, J., Baughman, A.M., Goto, T., Lin, M.C., and Tsai, S.B. (2003) The zebrafish as a vertebrate model of functional aging and very gradual senescence. Experimental gerontology. 38(7):777-786

Chan, J., Bayliss, P.E., Wood, J.M., and Roberts, T.M. (2002) Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell. 1(3):257-267

Chan, J., Mably, J.D., Serluca, F.C., Chen, J.-N., Goldstein, N.B., Thomas, M.C., Cleary, J.A., Brennan, C., Fishman, M.C., and Roberts, T.M. (2001) Morphogenesis of prechordal plate and notochord requires intact Eph/Ephrin B signaling. Developmental Biology. 234(2):470-482