ZFIN Lab: Chandrasekharappa Lab

ZFIN ID: ZDB-LAB-010423-1

Chandrasekharappa Lab

PI/Director:	Chandrasekharappa, Settara
Contact Person:	Chandrasekharappa, Settara
Email:	chandra@nhgri.nih.gov
URL:
Address:	Genetics and Molecular Biology Branch National Human Genome Research Institute National Institutes of Health Building 49, Room 3E-13 49 Convent Drive Bethesda, MD 20892-4442 USA
Country:	United States
Phone:	(301) 402-2344
Fax:	(301) 402-4929
Line Designation:	None assigned

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Anderson, Maria

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Simpson, C.L., Kimble, D.C., Chandrasekharappa, S.C., NISC Comparative Sequencing Program, Alqosayer, K., Holzinger, E., Carrington, B., McElderry, J., Sood, R., Al-Souqi, G., Albacha-Hejazi, H., Bailey-Wilson, J.E. (2023) A novel de novo TP63 mutation in whole-exome sequencing of a Syrian family with Oral cleft and ectrodactyly. Molecular genetics & genomic medicine. 11(8):e2179

Raman, R., Ramanagoudr-Bhojappa, R., Dhinoja, S., Ramaswami, M., Carrington, B., Jagadeeswaran, P., Chandrasekharappa, S.C. (2021) Pancytopenia and thrombosis defects in zebrafish mutants of Fanconi anemia genes. Blood cells, molecules & diseases. 93:102640

Shah, R.B., Kernan, J.L., van Hoogstraten, A., Ando, K., Li, Y., Belcher, A.L., Mininger, I., Bussenault, A.M., Raman, R., Ramanagoudr-Bhojappa, R., Huang, T.T., D'Andrea, A.D., Chandrasekharappa, S.C., Aggarwal, A.K., Thompson, R., Sidi, S. (2021) FANCI functions as a repair/apoptosis switch in response to DNA crosslinks. Developmental Cell. 56:2207-2222.e7

Adeyemo, A.A., Zaghloul, N.A., Chen, G., Doumatey, A.P., Leitch, C.C., Hostelley, T.L., Nesmith, J.E., Zhou, J., Bentley, A.R., Shriner, D., Fasanmade, O., Okafor, G., Eghan, B., Agyenim-Boateng, K., Chandrasekharappa, S., Adeleye, J., Balogun, W., Owusu, S., Amoah, A., Acheampong, J., Johnson, T., Oli, J., Adebamowo, C., South Africa Zulu Type 2 Diabetes Case-Control Study, Collins, F., Dunston, G., Rotimi, C.N. (2019) ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response. Nature communications. 10:3195

Rissone, A., Weinacht, K.G., la Marca, G., Bishop, K., Giocaliere, E., Jagadeesh, J., Felgentreff, K., Dobbs, K., Al-Herz, W., Jones, M., Chandrasekharappa, S., Kirby, M., Wincovitch, S., Simon, K.L., Itan, Y., DeVine, A., Schlaeger, T., Schambach, A., Sood, R., Notarangelo, L.D., Candotti, F. (2015) Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress. The Journal of experimental medicine. 212(8):1185-202

Sood, R., Carrington, B., Bishop, K., Jones, M., Rissone, A., Candotti, F., Chandrasekharappa, S.C., and Liu, P. (2013) Efficient Methods for Targeted Mutagenesis in Zebrafish Using Zinc-Finger Nucleases: Data from Targeting of Nine Genes Using CompoZr or CoDA ZFNs. PLoS One. 8(2):e57239

Sood, R., English, M.A., Jones, M., Mullikin, J., Wang, D.M., Anderson, M., Wu, D., Chandrasekharappa, S.C., Yu, J., Zhang, J., and Liu, P.P. (2006) Methods for reverse genetic screening in zebrafish by resequencing and TILLING. Methods (San Diego, Calif.). 39(3):220-227

Lorent, K., Yeo, S.Y., Oda, T., Chandrasekharappa, S., Chitnis, A., Matthews, R.P., and Pack, M. (2004) Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy. Development (Cambridge, England). 131(22):5753-5766

Itoh, M., Kim, C.-H., Palardy, G., Oda, T., Jiang, Y.-J., Maust, D., Yeo, S.-Y., Lorick, K., Wright, G.J., Ariza-McNaughton, L., Weissman, A.M., Lewis, J., Chandrasekharappa, S.C., and Chitnis, A.B. (2003) Mind Bomb is a ubiquitin ligase that is essential for efficient activation of notch signaling by Delta. Developmental Cell. 4(1):67-82

Kim, C.H., Oda, T., Itoh, M., Jiang, D., Artinger, K.B., Chandrasekharappa, S.C., Driever, W., and Chitnis, A.B. (2000) Repressor activity of Headless/Tcf3 is essential for vertebrate head formation. Nature. 407(6806):913-916

Manickam, P., Vogel, A.M., Agarwal, S.K., Oda, T., Spiegel, A.M., Marx, S.J., Collins, F.S., Weinstein, B.M., and Chandrasekharappa, S.C. (2000) Isolation, characterization, expression and functional analysis of the zebrafish ortholog MEN1. Mammalian genome : official journal of the International Mammalian Genome Society. 11(6):448-454