ZFIN Lab: Foulkes Lab

ZFIN ID: ZDB-LAB-001113-1

Foulkes Lab

PI/Director:	Foulkes, Nicholas-Simon
Contact Person:	Vallone, Daniela
Email:	daniela.vallone@kit.edu
URL:	http://www.itg.kit.edu/foulkes.php
Address:	Karlsruhe Institute of Technology (KIT) Campus North Institute of Toxicology and Genetics (ITG) Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen Germany
Country:	Germany
Phone:	+49 721 608-28728
Fax:	+49 721 608-23354
Line Designation:	ka

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Vallone, Daniela Post-Doc	Li, Ying Graduate Student	Pagano, Cristina Graduate Student
Zhao, Haiyu Graduate Student	Rastetter, Mareike Technical Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Godino-Gimeno, A., Leal, E., Chivite, M., Tormos, E., Rotllant, J., Vallone, D., Foulkes, N.S., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Role of melanocortin system in the locomotor activity rhythms and melatonin secretion as revealed by agouti-signalling protein (asip1) overexpression in zebrafish. Journal of pineal research. 76:e12939e12939

Foulkes, N.S. (2023) Photobiology: Fish eggs go sunny side up. Current biology : CB. 33:R810R812R810-R812

Geyer, N., Kaminsky, S., Confino, S., Livne, Z.B., Gothilf, Y., Foulkes, N.S., Vallone, D. (2023) Establishment of cell lines from individual zebrafish embryos. Laboratory animals. 57(5):518-528

Wang, Z., Li, K., Xu, Y., Song, Z., Lan, X., Pan, C., Zhang, S., Foulkes, N.S., Zhao, H. (2022) Ferroptosis contributes to nickel-induced developmental neurotoxicity in zebrafish. The Science of the total environment. 858(Pt 3):160078

Lucon-Xiccato, T., Loosli, F., Conti, F., Foulkes, N.S., Bertolucci, C. (2022) Comparison of anxiety-like and social behaviour in medaka and zebrafish. Scientific Reports. 12:10926

Confino, S., Dor, T., Tovin, A., Wexler, Y., Ben-Moshe Livne, Z., Kolker, M., Pisanty, O., Park, S.K., Geyer, N., Reiter, J., Edvardson, S., Mor-Shaked, H., Elpeleg, O., Vallone, D., Appelbaum, L., Foulkes, N.S., Gothilf, Y. (2022) A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System. International Journal of Molecular Sciences. 23(4):

Sangermano, F., Masi, M., Kumar, A., Peravali, R., Tuzi, A., Cimmino, A., Vallone, D., Giamundo, G., Conte, I., Evidente, A., Calabrò, V. (2021) In Vitro and In Vivo Toxicity Evaluation of Natural Products with Potential Applications as Biopesticides. toxins. 13(11):

Wang, Z., Zhao, H., Xu, Y., Zhao, J., Song, Z., Bi, Y., Li, Y., Lan, X., Pan, C., Foulkes, N.S., Zhang, S. (2021) Early-life lead exposure induces long-term toxicity in the central nervous system: From zebrafish larvae to juveniles and adults. The Science of the total environment. 804:150185

Ruggiero, G., Ben-Moshe Livne, Z., Wexler, Y., Geyer, N., Vallone, D., Gothilf, Y., Foulkes, N.S. (2021) Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions. Frontiers in molecular neuroscience. 14:718387

Schalm, G., Bruns, K., Drachenberg, N., Geyer, N., Foulkes, N.S., Bertolucci, C., Gerlach, G. (2021) Finding Nemo's clock reveals switch from nocturnal to diurnal activity. Scientific Reports. 11:6801

Zhao, H., Li, H., Du, J., Di Mauro, G., Lungu-Mitea, S., Geyer, N., Vallone, D., Bertolucci, C., Foulkes, N.S. (2021) Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair. PLoS Genetics. 17:e1009356

Li, Y., Yao, C., Zheng, Q., Yang, W., Niu, X., Zhang, Y., Lu, G. (2019) Occurrence and ecological implications of organophosphate triesters and diester degradation products in wastewater, river water, and tap water. Environmental pollution (Barking, Essex : 1987). 259:113810

Wang, C., Chen, Y., Wang, Y., Liu, X., Liu, Y., Li, Y., Chen, H., Fan, C., Wu, D., Yang, J. (2019) Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1. Journal of experimental & clinical cancer research : CR. 38:371

Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., Chen, Y., Deng, H., Wu, Q., Xiong, J., Meng, A., Yu, L. (2019) Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nature cell biology. 21:966-977

Zhang, Y., Takagi, N., Yuan, B., Zhou, Y., Si, N., Wang, H., Yang, J., Wei, X., Zhao, H., Bian, B. (2019) The protection of indolealkylamines on LPS-induced inflammation in zebrafish. Journal of ethnopharmacology. 243:112122

Elabd, S., Jabeen, N.A., Gerber, V., Peravali, R., Bourdon, J.C., Kancherla, S., Vallone, D., Blattner, C. (2019) Delay in development and behavioural abnormalities in the absence of p53 in zebrafish. PLoS One. 14:e0220069

Guarino, A.M., Mauro, G.D., Ruggiero, G., Geyer, N., Delicato, A., Foulkes, N.S., Vallone, D., Calabrò, V. (2019) YB-1 recruitment to stress granules in zebrafish cells reveals a differential adaptive response to stress. Scientific Reports. 9:9059

Pylatiuk, C., Zhao, H., Gursky, E., Reischl, M., Peravali, R., Foulkes, N., Loosli, F. (2019) DIY Automated Feeding and Motion Recording System for the Analysis of Fish Behavior. SLAS technology. 24(4):394-398

Zhao, H., Di Mauro, G., Lungu-Mitea, S., Negrini, P., Guarino, A.M., Frigato, E., Braunbeck, T., Ma, H., Lamparter, T., Vallone, D., Bertolucci, C., Foulkes, N.S. (2018) Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness. Current biology : CB. 28(20):3229-3243.e4

Pagano, C., Siauciunaite, R., Idda, M.L., Ruggiero, G., Ceinos, R.M., Pagano, M., Frigato, E., Bertolucci, C., Foulkes, N.S., Vallone, D. (2018) Evolution shapes the responsiveness of the D-box enhancer element to light and reactive oxygen species in vertebrates. Scientific Reports. 8:13180

Sloin, H.E., Ruggiero, G., Rubinstein, A., Smadja Storz, S., Foulkes, N.S., Gothilf, Y. (2018) Interactions between the circadian clock and TGF-β signaling pathway in zebrafish. PLoS One. 13:e0199777

Ceinos, R.M., Frigato, E., Pagano, C., Fröhlich, N., Negrini, P., Cavallari, N., Vallone, D., Fuselli, S., Bertolucci, C., Foulkes, N.S. (2018) Mutations in blind cavefish target the light-regulated circadian clock gene, period 2. Scientific Reports. 8:8754

Zhou, Y., Li, P., Brantner, A., Wang, H., Shu, X., Yang, J., Si, N., Han, L., Zhao, H., Bian, B. (2017) Chemical profiling analysis of Maca using UHPLC-ESI-Orbitrap MS coupled with UHPLC-ESI-QqQ MS and the neuroprotective study on its active ingredients. Scientific Reports. 7:44660

Dekens, M.P., Foulkes, N.S., Tessmar-Raible, K. (2017) Instrument design and protocol for the study of light controlled processes in aquatic organisms, and its application to examine the effect of infrared light on zebrafish. PLoS One. 12:e0172038

Pagano, C., di Martino, O., Ruggiero, G., Guarino, A.M., Mueller, N., Siauciunaite, R., Reischl, M., Foulkes, N.S., Vallone, D., Calabrò, V. (2017) The tumor-associated YB-1 protein: new player in the circadian control of cell proliferation. Oncotarget. 8(4):6193-6205

Yuan, Z., Li, Y., Hu, Y., You, J., Higashisaka, K., Nagano, K., Tsutsumi, Y., Gao, J. (2016) Chitosan nanoparticles and their Tween 80 modified counterparts disrupt the developmental profile of zebrafish embryos. International journal of pharmaceutics. 515(1-2):644-656

Lam, K.H., Li, Y., Li, Y., Lim, H.G., Zhou, Q., Shung, K.K. (2016) Multifunctional single beam acoustic tweezer for non-invasive cell/organism manipulation and tissue imaging. Scientific Reports. 6:37554

Ben-Moshe Livne, Z., Alon, S., Vallone, D., Bayleyen, Y., Tovin, A., Shainer, I., Nisembaum, L.G., Aviram, I., Smadja-Storz, S., Fuentes, M., Falcón, J., Eisenberg, E., Klein, D.C., Burgess, H.A., Foulkes, N.S., Gothilf, Y. (2016) Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. PLoS Genetics. 12:e1006445

Miao, W., Zhu, B., Xiao, X., Li, Y., Dirbaba, N.B., Zhou, B., Wu, H. (2015) Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 161C:117-126

Zou, P.F., Chang, M.X., Li, Y., Zhang, S.H., Fu, J.P., Chen, S.N., Nie, P. (2015) Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish & shellfish immunology. 43(1):13-24

Li, Y., Li, G., Görling, B., Luy, B., Du, J., Yan, J. (2015) Integrative Analysis of Circadian Transcriptome and Metabolic Network Reveals the Role of De Novo Purine Synthesis in Circadian Control of Cell Cycle. PLoS Computational Biology. 11:e1004086

Li, Y., Liu, X., Liu, K., Miao, W., Zhou, C., Li, Y., Wu, H. (2014) Extremely Low-Frequency Magnetic Fields Induce Developmental Toxicity and Apoptosis in Zebrafish (Danio rerio) Embryos. Biological trace element research. 162(1-3):324-32

Ben-Moshe, Z., Alon, S., Mracek, P., Faigenbloom, L., Tovin, A., Vatine, G.D., Eisenberg, E., Foulkes, N.S., and Gothilf, Y. (2014) The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light. Nucleic acids research. 42(6):3750-67

Villamizar, N., Vera, L.M., Foulkes, N.S., and Sánchez-Vázquez, F.J. (2014) Effect of Lighting Conditions on Zebrafish Growth and Development. Zebrafish. 11(2):173-81

Ben-Moshe, Z., Foulkes, N.S., Gothilf, Y. (2014) Functional Development of the Circadian Clock in the Zebrafish Pineal Gland. BioMed Research International. 2014:235781

Lahiri, K., Froehlich, N., Heyd, A., Foulkes, N.S., Vallone, D. (2014) Developmental stage-specific regulation of the circadian clock by temperature in zebrafish. BioMed Research International. 2014:930308

Mracek, P., Pagano, C., Fröhlich, N., Idda, M.L., Cuesta, I.H., Lopez-Olmeda, J.F., Sánchez-Vázquez, F.J., Vallone, D., and Foulkes, N.S. (2013) ERK Signaling Regulates Light-Induced Gene Expression via D-Box Enhancers in a Differential, Wavelength-Dependent Manner. PLoS One. 8(6):e67858

Cavodeassi, F., Bene, F.D., Fürthauer, M., Grabher, C., Herzog, W., Lehtonen, S., Linker, C., Mercader, N., Mikut, R., Norton, W., Strähle, U., Tiso, N., and Foulkes, N.S. (2013) Report of the Second European Zebrafish Principal Investigator Meeting in Karlsruhe, Germany, March 21-24, 2012. Zebrafish. 10(1):119-23

Elbaz, I., Foulkes, N.S., Gothilf, Y., and Appelbaum, L. (2013) Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish. Frontiers in neural circuits. 7:9

Smadja Storz, S., Tovin, A., Mracek, P., Alon, S., Foulkes, N.S., and Gothilf, Y. (2013) Casein kinase 1delta activity: a key element in the zebrafish circadian timing system. PLoS One. 8(1):e54189

Yu, W., Chai, H., Li, Y., Zhao, H., Xie, X., Zheng, H., Wang, C., Wang, X., Yang, G., Cai, X., Falck, J.R., and Yang, J. (2012) Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. Toxicology and applied pharmacology. 264(1):73-83

Idda, M.L., Bertolucci, C., Vallone, D., Gothilf, Y., Sánchez-Vázquez, F.J., and Foulkes, N.S. (2012) Circadian clocks: Lessons from fish. Progress in brain research. 199:41-57

Idda, M.L., Kage, E., Lopez-Olmedam, J.F., Mracek, P., Foulkes, N.S., and Vallone, D. (2012) Circadian timing of injury-induced cell proliferation in zebrafish. PLoS One. 7(3):e34203

Mracek, P., Santoriello, C., Idda, M.L., Pagano, C., Ben-Moshe, Z., Gothilf, Y., Vallone, D., and Foulkes, N.S. (2012) Regulation of per and cry Genes Reveals a Central Role for the D-Box Enhancer in Light-Dependent Gene Expression. PLoS One. 7(12):e51278

Tovin, A., Alon, S., Ben-Moshe, Z., Mracek, P., Vatine, G., Foulkes, N.S., Jacob-Hirsch, J., Rechavi, G., Toyama, R., Coon, S.L., Klein, D.C., Eisenberg, E., and Gothilf, Y. (2012) Systematic Identification of Rhythmic Genes Reveals camk1gb as a New Element in the Circadian Clockwork. PLoS Genetics. 8(12):e1003116

Cavallari, N., Frigato, E., Vallone, D., Fröhlich, N., Lopez-Olmeda, J.F., Foà, A., Berti, R., Sánchez-Vázquez, F.J., Bertolucci, C., and Foulkes, N.S. (2011) A Blind Circadian Clock in Cavefish Reveals that Opsins Mediate Peripheral Clock Photoreception. PLoS Biology. 9(9):e1001142

Vatine, G., Vallone, D., Gothilf, Y., and Foulkes, N.S. (2011) It's time to swim! Zebrafish and the circadian clock. FEBS letters. 585(10):1485-1494

Weger, B.D., Sahinbas, M., Otto, G.W., Mracek, P., Armant, O., Dolle, D., Lahiri, K., Vallone, D., Ettwiller, L., Geisler, R., Foulkes, N.S., and Dickmeis, T. (2011) The light responsive transcriptome of the zebrafish: function and regulation. PLoS One. 6(2):e17080

Ben-Moshe, Z., Vatine, G., Alon, S., Tovin, A., Mracek, P., Foulkes, N.S., and Gothilf, Y. (2010) Multiple PAR and E4BP4 bZIP transcription factors in zebrafish: diverse spatial and temporal expression patterns. Chronobiology International. 27(8):1509-1531

Vatine, G., Vallone, D., Appelbaum, L., Mracek, P., Ben-Moshe, Z., Lahiri, K., Gothilf, Y., and Foulkes, N.S. (2009) Light directs zebrafish period2 expression via conserved D and E boxes. PLoS Biology. 7(10):e1000223

Cossins, A.R., Williams, D.R., Foulkes, N.S., Berenbrink, M., and Kipar, A. (2009) Diverse cell-specific expression of myoglobin isoforms in brain, kidney, gill and liver of the hypoxia-tolerant carp and zebrafish. The Journal of experimental biology. 212(Pt 5):627-638

Dickmeis, T., Lahiri, K., Nica, G., Vallone, D., Santoriello, C., Neumann, C.J., Hammerschmidt, M., and Foulkes, N.S. (2007) Glucocorticoids Play a Key Role in Circadian Cell Cycle Rhythms. PLoS Biology. 5(4):e78

Vallone, D., Santoriello, C., Gondi, S.B., and Foulkes, N.S. (2007) Basic protocols for zebrafish cell lines: Maintenance and transfection. Methods in molecular biology (Clifton, N.J.). 362(1):429-441

Zilberman-Peled, B., Appelbaum, L., Vallone, D., Foulkes, N.S., Anava, S., Anzulovich, A., Coon, S.L., Klein, D.C., Falcon, J., Ron, B., and Gothilf, Y. (2007) Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream. Journal of neuroendocrinology. 19(1):46-53

Appelbaum, L., Vallone, D., Anzulovich, A., Ziv, L., Tom, M., Foulkes, N.S., and Gothilf, Y. (2006) Zebrafish arylalkylamine-N-acetyltransferase genes - targets for regulation of the circadian clock. Journal of molecular endocrinology. 36(2):337-347

Rembold, M., Lahiri, K., Foulkes, N.S., and Wittbrodt, J. (2006) Transgenesis in fish: efficient selection of transgenic fish by co-injection with a fluorescent reporter construct. Nature Protocols. 1(3):1133-1139

Lahiri, K., Vallone, D., Gondi, S.B., Santoriello, C., Dickmeis, T., and Foulkes, N.S. (2005) Temperature Regulates Transcription in the Zebrafish Circadian Clock. PLoS Genetics. 3(11):e351

Vallone, D., Lahiri, K., Dickmeis, T., and Foulkes, N.S. (2005) Zebrafish Cell Clocks Feel the Heat and See the Light!. Zebrafish. 2(3):171-187

Vallone, D., Gondi, S.B., Whitmore, D., and Foulkes, N.S. (2004) E-box function in a period gene repressed by light. Proceedings of the National Academy of Sciences of the United States of America. 101(12):4106-4111

Tamai, T.K., Vardhanabhuti, V., Foulkes, N.S., and Whitmore, D. (2004) Early embryonic light detection improves survival. Current biology : CB. 14(3):R104-105

Dekens, M.P.S., Santoriello, C., Vallone, D., Grassi, G., Whitmore, D., and Foulkes, N.S. (2003) Light regulates the cell cycle in zebrafish. Current biology : CB. 13(23):2051-2057

Tamai, T.K., Vardhanabhuti, V., Arthur, S., Foulkes, N.S., and Whitmore, D. (2003) Flies and fish: birds of a feather. Journal of neuroendocrinology. 15(4):344-349

Whitmore, D., Cermakian, N., Crosio, C., Foulkes, N.S., Pando, M.P., Travnickova, Z., and Sassone-Corsi, P. (2000) A clockwork organ. Biological chemistry. 381(9-10):793-800

Cermakian, N., Whitmore, D., Foulkes, N.S., and Sassone-Corsi, P. (2000) Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function. Proceedings of the National Academy of Sciences of the United States of America. 97(8):4339-4344

Whitmore, D., Foulkes, N.S., and Sassone-Corsi, P. (2000) Light acts directly on organs and cells in culture to set the vertebrate circadian clock. Nature. 404(6773):87-91

Cermakian, N., Whitmore, D., Foulkes, N.S., and Sassone-Corsi, P. (2000) Independent peripheral clocks and direct light entrainment within the zebrafish circadian system. Journal of molecular medicine (Berlin, Germany). 78(7):B46

Whitmore, D., Foulkes, N.S., Strähle, U., and Sassone-Corsi, P. (1998) Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators. Nature Neuroscience. 1(8):701-707