| Phenotype: | Kupffer's vesicle bicellular tight junction disorganized, abnormal |
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| Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
| Name: | Kupffer's vesicle |
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| Synonyms: | ciliated organ of asymmetry |
| Definition: | Small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period. Kupffer's vesicle has been compared to the mouse embryonic node. |
| Ontology: | Anatomy Ontology [ZFA:0000001] |
| Name: | bicellular tight junction |
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| Synonyms: | zonula occludens |
| Definition: | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. |
| Ontology: | GO: Cellular Component [GO:0005923] QuickGO AmiGO |
| Name: | disorganized |
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| Synonyms: | |
| Definition: | A structural quality inhering in a bearer by virtue of the bearer's lacking organisation. |
| Ontology: | Phenotypic Quality Ontology [PATO:0000937] |