Rhino-Deadlock-Cutoff Complex

Term ID

GO:1990469

Synonyms

• RDC complex
• rhi-del-cuff complex

Definition

Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation. 24906153

References

Ontology

GO: Cellular Component    QuickGO    AmiGO