Search Ontology:
GO: Cellular Component
UBR1-RAD6 ubiquitin ligase complex
- Term ID
- GO:1990303
- Synonyms
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- UBR1-RAD6 complex
- Definition
- A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. 19531475
- References
- Ontology
- GO: Cellular Component QuickGO AmiGO
- is a type of
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Phenotype
Phenotype caused by Genes