RQC-trigger complex

Term ID

GO:0180022

Synonyms

• activating signal cointegrator 1 complex
• RQT complex

Definition

A ribosome disassembly complex which dissociates stalled ribsome subunits as part of the ribosome quality control pathway. RQT complex is composed of a RNA helicase-family protein yeast Rqt2 (human ASCC3), a ubiquitin-binding protein yeast Rqt3, (human ASCC2), and Rqt4 (human TRIP4). The human complex has an additional component protein ASCC1 and can act as a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. (3)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO