chromosomal 5-methylcytosine DNA demethylation, oxidation pathway

Term ID

GO:0141167

Synonyms

• epigenetic 5-methylcytosine DNA demethylation, oxidation pathway
• epigenetic DNA demethylation, oxidation pathway

Definition

An epigenetic cytosine DNA demethylation pathway that starts with the enzymatic oxidation of the 5-methylcytosine (5meC) to generate 5-hydroxymethylcytosine (5hmC), which successively converted to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). A DNA glycosylase (e. g. TDG) recognizes the intermediate bases 5fC and 5caC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair. (3)

References

• Reactome:R-HSA-5221030

Ontology

GO: Biological Process    QuickGO    AmiGO