integrated stress response signaling

Term ID

GO:0140467

Synonyms

• ISR

Definition

The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. 27629041

References

• Wikipedia:Integrated_stress_response

Ontology

GO: Biological Process    QuickGO    AmiGO