Search Ontology:
GO: Biological Process
hypoxia-inducible factor-1alpha signaling pathway
- Term ID
- GO:0097411
- Synonyms
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- HIF1alpha pathway
- hypoxia-inducible factor signaling
- hypoxia-inducible factor-1alpha signalling pathway
- Definition
- The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. (2)
- References
- Ontology
- GO: Biological Process QuickGO AmiGO
- is part of
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- is a type of
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- negatively regulated by
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Phenotype
Phenotype caused by Genes