Search Ontology:
GO: Cellular Component

ripoptosome

Term ID
GO:0097342
Synonyms
  • necrosome
  • TNFR1 complex II
  • Tnfr1-CII
Definition
A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. (2)
References
Ontology
GO: Cellular Component    QuickGO    AmiGO
Relationships
is part of
is a type of
Phenotype
Phenotype caused by Genes
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