intrinsic apoptotic signaling pathway

Term ID

GO:0097193

Synonyms

induction of apoptosis by intracellular signals
intrinsic apoptosis
intrinsic apoptotic pathway
intrinsic apoptotic signalling pathway
mitochondrial-mediated apoptotic pathway

Definition

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). (3)

References

Reactome:R-HSA-109606

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is a type of: apoptotic signaling pathway intracellular signal transduction

apoptotic signaling pathway intracellular signal transduction Show first 5 Terms
has subtype: intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to hypoxia intrinsic apoptotic signaling pathway in response to nitrosative stress ... Show All 7 Terms

intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway in response to hypoxia intrinsic apoptotic signaling pathway in response to nitrosative stress intrinsic apoptotic signaling pathway in response to osmotic stress intrinsic apoptotic signaling pathway in response to oxidative stress Show first 5 Terms
negatively regulated by: negative regulation of intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway Show first 5 Terms
positively regulated by: positive regulation of intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway Show first 5 Terms
regulated by: regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway Show first 5 Terms

Phenotype

Phenotype caused by Genes