G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

Term ID

GO:0086033

Synonyms

• G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
• M2 receptor signalling pathway involved in negative regulation of heart rate
• muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate
• muscarinic receptor signalling pathway involved in negative regulation of heart rate

Definition

A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate. G_protein-gated_ion_channel

References

Ontology

GO: Biological Process    QuickGO    AmiGO