Ragulator complex

Term ID

GO:0071986

Synonyms

• EGO complex
• EGO-GSE complex
• GSE complex
• GTPase-containing complex for Gap1p sorting in the endosome
• MAPKSP1/ROBLD3/C11orf59 complex
• Rag GEF

Definition

A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). (7)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO