ubiquitin-dependent protein catabolic process via the N-end rule pathway

Term ID

GO:0071596

Synonyms

• ubiquitin-dependent protein breakdown via the N-end rule pathway
• ubiquitin-dependent protein catabolism via the N-end rule pathway
• ubiquitin-dependent protein degradation via the N-end rule pathway

Definition

The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. (2)

References

Ontology

GO: Biological Process    QuickGO    AmiGO