nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

Term ID

GO:0070478

Synonyms

• 3'-5' NMD
• 3'-5' nonsense-mediated decay
• 3'-5' nonsense-mediated mRNA decay
• nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay
• nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay
• nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay

Definition

The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. 12769863

References

Ontology

GO: Biological Process    QuickGO    AmiGO