ERK1 and ERK2 cascade

Term ID

GO:0070371

Synonyms

• ERK cascade
• ERK1 and ERK2 signaling pathway
• ERK1 and ERK2 signalling pathway
• ERK1 cascade
• ERK1/2 cascade
• ERK2 cascade
• extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
• extracellular signal-regulated kinase 1/2 cascade
• MAPK1 cascade
• MAPK3 cascade

Definition

A MAPK cascade containing at least the ERK1 or ERK2 MAP kinases. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK1 or ERK2. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier. The ERK1/ERK2 cascade is activated by mitogens, growth factors, G protein-coupled receptors, and results in cellular responses such as cell proliferation, cell differentiation and development. (3)

References

Ontology

GO: Biological Process    QuickGO    AmiGO