chaperone-mediated autophagy

Term ID

GO:0061684

Synonyms

CASA
chaperone-assisted selective autophagy
CMA

Definition

The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded. (2)

References

Reactome:R-HSA-9613829
Wikipedia:Chaperone-mediated_autophagy

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

has parts: chaperone-mediated autophagy translocation complex assembly protein targeting to lysosome involved in chaperone-mediated autophagy

chaperone-mediated autophagy translocation complex assembly protein targeting to lysosome involved in chaperone-mediated autophagy Show first 5 Terms
is a type of: autophagy protein catabolic process

autophagy protein catabolic process Show first 5 Terms
has_part: protein carrier chaperone protein-folding chaperone binding signaling receptor binding

protein carrier chaperone protein-folding chaperone binding signaling receptor binding Show first 5 Terms
negatively regulated by: negative regulation of chaperone-mediated autophagy

negative regulation of chaperone-mediated autophagy Show first 5 Terms
positively regulated by: positive regulation of chaperone-mediated autophagy

positive regulation of chaperone-mediated autophagy Show first 5 Terms
regulated by: regulation of chaperone-mediated autophagy

regulation of chaperone-mediated autophagy Show first 5 Terms

Phenotype

Phenotype caused by Genes