isotype switching

Term ID

GO:0045190

Synonyms

class switch recombination
class switching
isotype switch recombination

Definition

The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. 0781735149

References

Wikipedia:Immunoglobulin_class_switching

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is a type of: B cell activation involved in immune response somatic recombination of immunoglobulin genes involved in immune response

B cell activation involved in immune response somatic recombination of immunoglobulin genes involved in immune response Show first 5 Terms
has subtype: isotype switching to IgA isotypes isotype switching to IgD isotypes isotype switching to IgE isotypes isotype switching to IgG isotypes

isotype switching to IgA isotypes isotype switching to IgD isotypes isotype switching to IgE isotypes isotype switching to IgG isotypes Show first 5 Terms
inverse has_completed: class switched memory B cell

class switched memory B cell Show first 5 Terms
inverse has_not_completed: immature B cell

immature B cell Show first 5 Terms
negatively regulated by: negative regulation of isotype switching

negative regulation of isotype switching Show first 5 Terms
positively regulated by: positive regulation of isotype switching

positive regulation of isotype switching Show first 5 Terms
regulated by: regulation of isotype switching

regulation of isotype switching Show first 5 Terms

Phenotype

Phenotype caused by Genes